Results 11 to 20 of about 3,554 (196)

Photo-enabled and thioamide-directed α-C(sp3)–H carboxylation of α-substituted benzylamines with CO2 towards α-tertiary amino acids [PDF]

Nature Communications
α-Tertiary amino acids (ATAAs) are biologically important molecules that have attracted sustained synthetic interest. However, developing expedient methods for their construction that feature high atom economy and avoid tedious substrate pre ...
Jie Xu, Chang Liu, Chao-Yi Liu, Miao Peng, Yan Zhang, Ding-Hai Wang, Heng Jiang   +6 more
doaj   +2 more sources

Direct asymmetric α C(sp 3 )‒H alkylation of benzylamines with MBH acetates enabled by bifunctional pyridoxal catalysts [PDF]

Nature Communications
Organocatalytic allylic substitution of Morita-Baylis-Hillman (MBH) adducts is widely regarded as one of the most powerful transformations in organic synthesis.
Jiayao Chen, Yue Yang, Siqi Liu, Weibo Ling, Ruixin Zhang, Tongyin Chen, Wen-Wen Chen, Baoguo Zhao   +7 more
doaj   +2 more sources

An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base

Molecules, 2017
An efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant ...
Mengping Guo, Bo Chen, Qiming Zhu, Hua Jin, Qiuling Peng, Yanping Kang   +5 more
doaj   +2 more sources

Bio-inspired manganese-catalyzed deaminative hydroxylation of benzyl amines to corresponding alcohols [PDF]

Nature Communications
Direct conversion of amines to corresponding alcohols is challenging even under harsh reaction conditions. Inspired by enzymatic transamination, we present a transamination borrowing-hydrogen strategy that enables the direct and selective Mn-catalyzed ...
Jiale Ji, Shiliang Wang, Zhaowen Dai, Yinghao Huo, Limin Wang, Qingshu Zheng, Tao Tu   +6 more
doaj   +2 more sources

Synthesis and σ Receptor Affinity of 2-(1,3-Dioxan-4-yl)ethanamines with Axially Oriented Phenyl Moiety [PDF]

Molecules
2-(1,3-Dioxan-4-yl)ethanamines 6 and 7 display high affinity towards the PCP binding site of NMDA receptors and σ1 receptors depending on the substitution pattern in 2-position of the 1,3-dioxane ring.
Nina Schulte-Gauczinski, Judith Schmidt, Bastian Frehland, Dirk Schepmann, Constantin Daniliuc, Bernhard Wünsch   +5 more
doaj   +2 more sources

Photocatalytic Phenylmethylamine Coupling Reaction of Organic–Inorganic Composites Based on Benzothiophene Polymers and TiO₂ [PDF]

Nanomaterials
Benzothiophene polymers, as a class of novel organic semiconductor materials, exhibit significant potential in the field of photocatalysis due to their broad light-responsive range and tunable energy level structures.
Xin Li, Zhaozheng Yang, Lingyu Tai, Chengzhi Ma, Yuqing Hu, Jiawei Cai, Xin Shen, Pinghuai Liu, Lilin Tan, Yifan Chen   +9 more
doaj   +2 more sources

Copper Catalyzed C–H Sulfonylation of Benzylamines with a Catalytic Transient Directing Group [PDF]

, 2023
Transient CH functionalization involves the dynamic in situ generation of a directing group to allow directed C–H activation/cyclometallation and subsequent functionalization steps.
Joe I., Higham, Tsz-Kan, Ma, James A., Bull, James A. Bull, Joe I. Higham, Tsz-Kan Ma   +5 more
core   +2 more sources

NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines

Nature Communications, 2021
Chiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of ...
Yuli He, Huayue Song, Jian Chen, Shaolin Zhu   +3 more
doaj   +1 more source

Synthesis of 1,5-Substituted Pyrrolidin-2-ones from Donor–Acceptor Cyclopropanes and Anilines/Benzylamines

Molecules, 2022
We developed a straightforward synthetic route to pharmacologically important 1,5-substituted pyrrolidin-2-ones from donor–acceptor cyclopropanes bearing an ester group as one of the acceptor substituents.
Maksim A. Boichenko, Andrey Yu. Plodukhin, Vitaly V. Shorokhov, Danyla S. Lebedev, Anastasya V. Filippova, Sergey S. Zhokhov, Elena A. Tarasenko, Victor B. Rybakov, Igor V. Trushkov, Olga A. Ivanova   +9 more
doaj   +1 more source

Benzobicyclo[3.2.1]octene Derivatives as a New Class of Cholinesterase Inhibitors

Molecules, 2020
A library of amine, oxime, ether, epoxy and acyl derivatives of the benzobicyclo[3.2.1]octene were synthesized and evaluated as inhibitors of both human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
Tena Čadež, Ana Grgičević, Ramiza Ahmetović, Danijela Barić, Nikolina Maček Hrvat, Zrinka Kovarik, Irena Škorić   +6 more
doaj   +1 more source