Results 41 to 50 of about 3,554 (196)

Macrocyclization of ω‐Isocyano Aldehydes

Angewandte Chemie, EarlyView.
The ω‐isocyano aldehydes readily undergo cyclization to afford α‐acyloxy, α‐hydroxy, α‐acetamido, and α‐keto macrolactams, as well as tetrazole‐fused macrocycles, via C(sp3)─C(sp2) bond formation, providing access to diverse α‐functionalized medium‐sized lactams and macrolactams. ABSTRACT Medium‐sized rings and macrocycles constitute a privileged class
Baochao Yang, Teerawat Songsichan, Cyril Piemontesi, Qian Wang, Jieping Zhu   +4 more
wiley   +2 more sources

Pd(II)-Catalyzed Direct Sulfonylation of Benzylamines Using Sodium Sulfinates

, 2019
A Pd­(II)-catalyzed direct sulfonylation of benzylamines with sodium sulfinates using a removable bidentate directing group is illustrated. The transformation is highly regioselective and tolerates wide functional groups.
Rajarshi Samanta (1392841), Ujjwal Karmakar (1392844)   +1 more
core   +2 more sources

Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3

Molecules, 2021
17β-Hydroxysteroid dehydrogenase type 3 (17β-HSD3) is expressed at high levels in testes and seminal vesicles; it is also present in prostate tissue and involved in gonadal and non-gonadal testosterone biosynthesis.
Nigel Vicker, Helen V. Bailey, Joanna M. Day, Mary F. Mahon, Andrew Smith, Helena J. Tutill, Atul Purohit, Barry V. L. Potter   +7 more
doaj   +1 more source

Metal-Free Synthesis of 2-Substituted Quinazolines via Green Oxidation of o-Aminobenzylamines: Practical Construction of N-Containing Heterocycles Based on a Salicylic Acid-Catalyzed Oxidation System

Frontiers in Chemistry, 2022
Conventional quinazoline synthesis methods involve a highly multistep reaction, and often require excess amounts of substrate to control the product selectivity, leading to significant resource wastage.
Yuki Yamamoto, Chihiro Yamakawa, Riku Nishimura, Chun-Ping Dong, Shintaro Kodama, Akihiro Nomoto, Michio Ueshima, Akiya Ogawa   +7 more
doaj   +1 more source

Expedient Cobalt-Catalyzed C–H Alkynylation of (Enantiopure) Benzylamines

, 2016
A unified strategy for cobalt-catalyzed ortho-C–H bond alkynylation of benzylamines is reported. Simple, commercially available CoBr2 was used as a cobalt source. The developed alkynylation strategy is robust and efficient and has a broad substrate scope
Vinod G. Landge (1412281), Ekambaram Balaraman (1412284), Jagannath Rana (3189816), Siba P. Midya (3189819), Dinesh R. Shinde (1814056)   +4 more
core   +1 more source

Efficient Photocatalytic Selective Oxidation of Benzylamines over Cobalt Molecular Catalyst Covalently Bonded to Carboxyl Functionalized Carbon Nitride

Advanced Energy & Sustainability Research, 2023
Photocatalysis is accepted as a promising method for selective oxidative coupling of amine to imine. However, owing to the rapid dehydrogenation of the generated imine intermediate of α‐amino hydrogen to butyronitrile, it remains a huge challenge to ...
Chuntao Wang, Haixia Li, Yingxin Guo, Hui Zhao, Yuming Dong, Yongfa Zhu   +5 more
doaj   +1 more source

Synthesis of 1,2,4-Trisubstituted-(1H)‑imidazoles through Cu(OTf)₂‑/I₂‑Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines

, 2018
1,2,4-Trisubstituted-(1H)-imidazoles have been synthesized by the Cu­(OTf)2- and I2-catalyzed unusual C–C bond cleavage of chalcones and benzylamines. After the α,β-unsaturated C–C bond cleavage, the β-portion is eliminated from the reaction.
Chettiyan Thodi F. Salfeena (5535269), Rincy Davis (5535266), Renjitha Jalaja (5440229), Eringathodi Suresh (595864), Sasidhar B. Somappa (5440217)   +4 more
core   +2 more sources

Novel Convenient Approach to 6-, 7-, and 8-Numbered Nitrogen Heterocycles Incorporating Endocyclic Sulfonamide Fragment

Molecules, 2020
A new effective method for the construction of nitrogen heterocycles incorporating endocyclic pharmacophore sulfonamide fragment, based on the use of easy accessible N-(chlorosulfonyl)imidoyl chloride, CCl3C(Cl)=NSO2Cl (1), has been developed.
Oleksandr Shalimov, Eduard Rusanov, Oksana Muzychka, Petro Onys’ko   +3 more
doaj   +1 more source

Rhodium(III)-Catalyzed Oxidative C–H/C–H Cross-Coupling of Heteroarenes and Masked Benzylamines

, 2016
The first example of oxidative C–H/C–H cross-coupling of oxalyl amide-protected benzylamines and various heteroarenes in the presence of a rhodium­(III) catalyst has been developed.
Da-Qing Shi (1528189), Chunchen Yuan (3348158), Guobao Li (122160), Jundie Hu (1545613), Yingsheng Zhao (1528195), Zhi-Bin Huang (1528198)   +5 more
core   +1 more source

New Synthesis of Substituted Benzylamines. Novel Application of the Mitsunobu Reaction To Convert Substituted Benzyl Alcohols to Amines^†

, 2016
New Synthesis of Substituted Benzylamines. Novel Application of the Mitsunobu Reaction To Convert Substituted Benzyl Alcohols to Amines†
Sham S. Nikam (2537479), Michael F. Rafferty (3039336), Brian E. Kornberg (2537458)   +2 more
core   +2 more sources