Results 61 to 70 of about 4,788 (230)

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Synthesis and Antifungal Studies of (2E)-N-Benzyl-N′-phenylbut-2-enediamide and (2E)-N,N′-Dibenzylbut-2-enediamide Analogues

Journal of Chemistry, 2013
A series of eleven butanediamine analogues, of which nine were new, were synthesized by the nucleophilic substitution of aromatic amines and benzylamines with maleic anhydride and tested on four yeast strains of Candida species using the broth ...
Habila J. Dama, Kandappa H. Reddy, Patrick Govender, Neil A. Koorbanally   +3 more
doaj   +1 more source

Protecting‐Group‐Free Amidation of Amino Acids using Lewis Acid Catalysts [PDF]

, 2018
Amidation of unprotected amino acids has been investigated using a variety of ‘classical“ coupling reagents, stoichiometric or catalytic group(IV) metal salts, and boron Lewis acids.
Badland, M, Boulton, LT, Karaluka, V, Lanigan, RM, Sabatini, M, Sheppard, TD   +5 more
core   +1 more source

Unlocking Heterobimetallic Architectures in a Symmetric PNNP Ligand Environment

Chemistry – A European Journal, EarlyView.
A symmetric PNNP ligand enables the modular assembly of heterobimetallic ZnRu and CoRu complexes from a mononuclear Ru(II) precursor. Ligand deprotonation triggers dearomatization and contraction of the metal–metal distance. Combined DFT and QTAIM analyses reveal metallophilic interaction in CoRu but not in ZnRu, highlighting controllable geometric and
Stanislav Melnikov, Menne W. P. Verkooijen, Jop Verduin, Martin Lutz, Daniël L. J. Broere   +4 more
wiley   +1 more source

Bayesian Optimization of Solvent‐Free Thermal Amidation via Reactive Extrusion

Chemistry – A European Journal, EarlyView.
Thermal amidation between a carboxylic acid and an amine was successfully conducted in an extruder in the absence of solvent, coupling agent, or catalyst, relying on an adapted Bayesian Optimization protocol. Active pharmaceutical ingredient moclobemide was synthesized on a larger scale, achieving excellent yield and low Process Mass Intensity (PMI ...
Matthieu Lavayssiere, Xavier Bantreil, Frédéric Lamaty   +2 more
wiley   +1 more source

S‐Doped Carbon Nitride Thin Films From a Triazole Precursor

Carbon Innovation, EarlyView.
Sulfur‐functionalized carbon nitride thin films are synthesized via low‐temperature chemical vapor deposition using a triazole‐derived precursor. Tunable sulfur incorporation modulates electronic and optical properties and enables efficient visible‐light photocatalysis with high conversion and selectivity.
Yen‐Han Wang, Enis Oğuzhan Eren, Baris Kumru, Paolo Giusto   +3 more
wiley   +1 more source

Substituted N-Benzylpyrazine-2-carboxamides: Synthesis and Biological Evaluation

Molecules, 2012
A series of twelve amides was synthesized via aminolysis of substituted pyrazinecarboxylic acid chlorides with substituted benzylamines. Compounds were characterized with analytical data and assayed in vitro for their antimycobacterial, antifungal ...
Katarína Kráľová, Pavla Paterová, Matúš Peško, Vladimír Kubíček, Martin Doležal, Drahomíra Eibinová, Barbora Servusová   +6 more
doaj   +1 more source

Design, synthesis and cholinesterase inhibitory properties of new oxazole benzylamine derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are primary targets in attenuating the symptoms of neurodegenerative diseases.
Ivana Šagud, Nikolina Maček Hrvat, Ana Grgičević, Tena Čadež, Josipa Hodak, Milena Dragojević, Kornelija Lasić, Zrinka Kovarik, Irena Škorić   +8 more
doaj   +1 more source

Modeling complex metabolic reactions, ecological systems, and financial and legal networks with MIANN models based on Markov-Wiener node descriptors [PDF]

, 2013
[Abstract] The use of numerical parameters in Complex Network analysis is expanding to new fields of application. At a molecular level, we can use them to describe the molecular structure of chemical entities, protein interactions, or metabolic networks.
Agrawal V. K., Aguero-Chapin G., Aguero-Chapin G., Aguero-Chapin G., Alderson R. G., Alejandro Pazos, Aliuska Duardo-Sánchez, Antonio López-Díaz, Bajaj S., Bajaj S., Bajaj S., Bajaj S., Balaban A. T., Batagelj V., Berca M. N., Besalu E., Bhattacharjee B., Bisson W. H., Bisson W. H., Boccaletti S., Bonchev D., Bonchev D., Bonchev D., Bonchev D., Bornholdt S., Caballero J., Casanola-Martin G. M., Castillo-Garit J. A., Cedeno W., Chatterjee A. K., Chen J., Concu R., Consonni V., Cordeiro M. N., Cordero F., Cristian R. Munteanu, Dave K., Dave K., Dave K., Diudea M. V., Duardo-Sanchez A., Duardo-Sanchez A., Duardo-Sánchez A., Duardo-Sánchez A., Estrada E., Estrada E., Estrada E., Faivre C., Fowler J. H., Frank E., Garcia I., García I., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., Gonzalez-Diaz H., González-Díaz H., González-Díaz H., González-Díaz H., González-Díaz H., González-Díaz H., Gupta S., Harary F., Helguera A. M., Hill T., Hopfield J. J., Hosoya H., Hosoya H., Humberto González-Díaz, Ivanciuc O., Ivanciuc T., Jayadeepa R. M., Jeong H., Junker B. H., Katritzky A. R., Katritzky A. R., Khan M. T., Kier L. B., Kobe B., Kramer C., Kufareva I., Kumar V., Lather V., Lee D. S., Lin J. H., Luan F., Lukovits I., Lukovits I., Mandado M., Mandloi M., Marrero-Ponce Y., Marrero-Ponce Y., Marzaro G., Mazurie A., Mendiratta S., Mortier J., Munteanu C. R., Newman M., Ortore G., Pablo Riera-Fernández, Popelier P., Prado-Prado F., Prado-Prado F., Prado-Prado F., Ramos de Armas R., Riera-Fernandez I., Riera-Fernandez P., Riera-Fernandez P., Riera-Fernandez P., Riera-Fernández P., Rincon D. A., Rodriguez-Soca Y., Rosa da Silva M., Rosenblatt F., Saladino G., Santana L., Sardana S., Sardana S., Sharma N., Speck-Planche A., Tetko I. V., Thomas S., Todeschini R., Van Calenbergh S., Vilar S., Vilar S., Vina D., Wan S. B., Wang J. F., Wasserman S., Wiener H., Wiener H., Wiener H., Wiener H., Zhang T.   +144 more
core   +2 more sources

Synthesis and characterization of amphiphilic nitroxide 1,1,3,3–tetraethylisoindoline–2–oxyl–5–sodium sulfonate (TEIOSNa)

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract The synthesis and characterization of an amphiphilic nitroxide to be used as a controlling agent in a nitroxide‐mediated living radical polymerization in aqueous dispersion media is presented. In the first stage of nitroxide synthesis (phthalimide protection), two reaction methods were employed: traditional and microwave.
Enrique García‐Leal, Martha Eugenia Albores Velasco, René O. Vargas, Rubén Mil‐Martínez   +3 more
wiley   +1 more source