Results 61 to 70 of about 3,282 (218)

Synthesis of Oxazolyl‐Piperidines Bearing a Quaternary Stereocenter Through a Multicomponent Reaction Involving α‐Isocyanoacetates and Piperidones

European Journal of Organic Chemistry, EarlyView.
Straightforward access to oxazole‐containing piperidines through a multicomponent reaction from α‐isocyanoacetates is described. By expanding the reactivity of these a‐isocyanoacetates from aldehydes to ketones, this process efficiently delivers oxazolyl‐piperidines bearing a quaternary stereocenter as valuable scaffolds relevant to drug discovery. The
Roshan Chandrakant Kajare, Gilles Argouarch, Nicolas Gouault, Claudia Lalli   +3 more
wiley   +1 more source

Design, synthesis and cholinesterase inhibitory properties of new oxazole benzylamine derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are primary targets in attenuating the symptoms of neurodegenerative diseases.
Ivana Šagud, Nikolina Maček Hrvat, Ana Grgičević, Tena Čadež, Josipa Hodak, Milena Dragojević, Kornelija Lasić, Zrinka Kovarik, Irena Škorić   +8 more
doaj   +1 more source

Domino Polymerization for the Synthesis of Reductively Degradable Poly(disulfide)s With Arbitrary Side‐Chain Structures

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
We developed a novel domino polymerization to synthesize reductively degradable poly(disulfide)s with tunable side chains. A novel monomer bearing thiolactone and pyridyl disulfide groups reacts with various amines, enabling continuous ring‐opening and disulfide exchange.
Yukiya Kitayama, Ryodai Sakamoto, Atsushi Harada   +2 more
wiley   +2 more sources

Hydrogen Atom Transfer: An Intramolecular Main‐Group Metal‐Ligand Cooperative Biradical Pathway

Chinese Journal of Chemistry, Volume 44, Issue 13, Page 2121-2127, 1 July 2026.
The molecular system consisting of a main‐group metal and a redox‐active ligand, ((2,6‐iPr2C6H3)NC(Me))2AlCl(THF), has been shown to react with azides and diazomethanes, yielding products through both a biradical intermediate and a hydrogen atom transfer process.
Ting Chen, Shaoying Ju, Rui Wei, Weili Yan, Yufen Zhao, Douglas W. Stephan, Yile Wu   +6 more
wiley   +1 more source

Kinetic Resolution of Benzylamines via Palladium(II)-Catalyzed C–H Cross-Coupling

, 2016
A Pd­(II)-catalyzed enantioselective C–H cross-coupling of benzylamines via kinetic resolution has been achieved using chiral mono-N-protected α-amino-O-methylhydroxamic acid (MPAHA) ligands.
Gang Chen (107840), Jin-Quan Yu (1303500), Kai-Jiong Xiao (1321176), Ling Chu (434707)   +3 more
core   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 599-623, July/August 2026.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Lewis acid-catalyzed oxidation of benzylamines to benzamides.

, 2012
International audienceA novel Lewis acid-catalyzed oxidation of benzylamines to the corresponding amides has been developed. Using 10 mol% of ZnBr(2) or FeCl(3) as the catalyst and TBHP as the oxidant, amides were produced under mild ...
Beller, Matthias, Dixneuf, Pierre H., Bheeter, Charles Beromeo, Neumann, Helfried, Wu, Xiao-Feng   +4 more
core   +1 more source

Redox‐Active Guanidines

ChemElectroChem, Volume 13, Issue 12, 17 June 2026.
Redox‐active guanidines, comprising guanidino‐functionalized aromatics (GFAs) and redox‐active urea azines (RAAs), are electron donors and strong Lewis and Brønsted bases that are used in several applications. They act as redox‐active ligands in bistable coordination compounds and as reagents in dehydrogenative coupling reactions and proton‐coupled ...
Hans‐Jörg Himmel
wiley   +1 more source

Benzylamine oxidase from brain microvessels

FEBS Letters, 1983
Copper‐containing benzylamine oxidase with a specific activity of 200 units was isolated from bovine brain microvessels. It was shown that the content of the enzyme in microvessels was significantly higher as compared with large blood vessels such as heart aorta. Some physico‐chemical properties of the enzyme were determined.
Mehrabian, Z.B., Nalbandyan, R.M.
openaire   +2 more sources