Results 61 to 70 of about 2,572 (189)

From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe, Ahmet Buğra Aksel, Ezgi Pehlivanlar Yavrucu, Hilal Zıvalı, Begüm Nurpelin Sağlık Özkan, İnci Selin Doğan   +5 more
wiley   +1 more source

Synthesis of Cyclic Sulfilimines and Sulfoximines via Copper‐Mediated C(sp2)–H Sulfanylation of Benzylamines with a Catalytic Transient Directing Group

ChemistryEurope
C─H functionalization presents opportunities to streamline the synthesis of valuable molecular structures. This study details the development of a copper‐mediated, transient C(sp2)–H sulfanylation of benzylamines with a transient directing group (TDG ...
Tsz‐Kan Ma, Peerawat Saejong, King‐Long Or, Callum S. Begg, James A. Bull   +4 more
doaj   +1 more source

Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions

Molecules, 2017
The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound 1) or N-benzylaminobenzylphosphonic (compound 2) acid depending on the reaction conditions.
Patrycja Miszczyk, Ilona Turowska-Tyrk, Paweł Kafarski, Ewa Chmielewska   +3 more
doaj   +1 more source

Curcumin‐Enabled Metal‐Free Photocatalytic Oxidation of Aryl‐ and Alkyl‐methanamines to Imines Under Green Conditions

ChemSusChem, Volume 19, Issue 16, 27 August 2026.
Curcumin, a natural polyphenol, enables a fully bio‐based and metal‐free photocatalytic system for the aerobic oxidation of aryl‐ and alkyl‐methanamines to imines under blue light. Using 2‐methyltetrahydrofuran (2‐MeTHF) as a renewable solvent and molecular oxygen as the sole oxidant, the protocol affords up to 98% yield.
Tommaso Castiglia, Maria Angela Chiarella, Andrea Shati, Andrea Aloia, Stefano Savino, Cosimo Annese, Angelo Nacci, Antonio Monopoli   +7 more
wiley   +1 more source

Molecular Conformations and Biological Activity of N-Hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides

Scientia Pharmaceutica, 2018
The analysis of our previous studies on the search for synthetic analgesics among N-R-amides of bicyclic hetaryl-3-carboxylic acids has been performed; on its basis N-hetaryl(aryl)-alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides have ...
Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lina A. Grinevich, Vasyl V. Grynenko, Galina Sim   +8 more
doaj   +1 more source

Isotelluroureas for Asymmetric C1 Ammonium Enolate Reactions

European Journal of Organic Chemistry, Volume 29, Issue 31, 19 August 2026.
Chiral isotelluroureas are powerful catalysts for a variety of C─C bond forming C1 ammonium enolate transformations. Isotelluroureas (ITeUs) have recently been introduced as a novel class of highly nucleophilic Lewis base catalysts. Herein, we systematically screened them for their potential to facilitate C1 ammonium enolate transformations and ...
Fereshteh Khorasani, Lotte Stockhammer, Magdalena Piringer, Mario Waser   +3 more
wiley   +1 more source

Benzylamine oxidase from brain microvessels

FEBS Letters, 1983
Copper‐containing benzylamine oxidase with a specific activity of 200 units was isolated from bovine brain microvessels. It was shown that the content of the enzyme in microvessels was significantly higher as compared with large blood vessels such as heart aorta. Some physico‐chemical properties of the enzyme were determined.
Mehrabian, Z.B., Nalbandyan, R.M.
openaire   +2 more sources

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni, Maria Luisa Di Paolo, Antonio Laghezza, Giorgio Cozza, Francesco Piazzola, Laura Facci, Emma Marcolin, Elena Roggiolani, Luca Piemontese, Anna Minarini, Morena Zusso, Lisa Dalla Via, Michela Rosini   +12 more
wiley   +1 more source

Catalytic Deuteration of Amines in Water (D2O) With Ir, Ru, and Rh Pentamethylcyclopentadienyl Dioxime Complexes

ChemistryEurope, Volume 4, Issue 8, August 2026.
A new family of pentamethylcyclopentadienyl (C5Me5, Cp*) iridium(III), rhodium(III), and ruthenium(III) complexes bearing bidentate 1,2‐dioxime ligands was developed and their catalytic performances were evaluated in the hydrogen‐borrowing‐type H/D exchange of amines using D2O as both solvent and deuterium source. Iridium derivatives achieved excellent
Francesco Taglieri, Maria Edith Casacchia, Anna Pisani, Assunta Cortese, Stefano Zacchini, Marcello Crucianelli, Fabio Marchetti, Andrea Di Giuseppe, Lorenzo Biancalana   +8 more
wiley   +1 more source

Mechanochemistry as an Emerging Tool for Organofluorine Chemistry

Chemistry–Methods, Volume 6, Issue 8, August 2026.
Fluorinated scaffolds are central across many areas of chemistry, driving the demand for efficient and sustainable synthetic methods. Mechanochemistry has emerged as a powerful alternative to conventional approaches, offering reduced environmental impact, shorter reaction times, and unique reactivity and selectivity.
Marie Caldiero, Nicolas Delcroix, Vitalii Solomin, Thomas Castanheiro   +3 more
wiley   +1 more source