Results 81 to 90 of about 4,788 (230)

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Multimetallic (de)hydrogenation catalysed processes [PDF]

, 2016
The use of different metals working together in a synergistic way, allows synthetic transformations that are not achievable by other means. The metal cooperation becomes important in catalytic processes for the synthesis of sophisticated molecules or
Mata Martínez, Jose A, Ventura Espinosa, David   +1 more
core   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Synthesis of enamines and their bromination [PDF]

, 2011
Enamines represent an important class of reactive intermediates in organic synthesis. They are frequently used as a potential building block to access several types of heterocyclic ring systems and biologically active analogues.
Thakur, Vasundhara
core  

Comparison of lipid membrane-water partitioning with various organic solvent-water partitions of neutral species and ionic species: Uniqueness of cerasome as a model for the stratum corneum in partition processes [PDF]

, 2015
YesLipid membrane-water partitions (e.g., immobilized artificial membrane systems where the lipid membrane is a neutral phospholipid monolayer bound to gel beads) were compared to various organic solvent-water partitions using linear free energy ...
Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Alfred Fahr, Austin, Avdeef, Balon, Balon, Bano, Beigi, Carrozzino, Collander, Desmond J. Tobin, Finkelstein, Fruttero, Ishihama, Keda Zhang, Leo, Liu, Liu, Lukacova, Mason, Meindl, Michael H. Abraham, Moore, Ong, Ong, Osterberg, Pauletti, Pidgeon, Rand, Sarmento, Tejwani, Wiedmer, Wiedmer, William E. Acree, Xiang, Xiangli Liu, Zhang, Zhang   +49 more
core   +1 more source

A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols. [PDF]

, 2020
Catechol dehydroxylation is a central chemical transformation in the gut microbial metabolism of plant- and host-derived small molecules. However, the molecular basis for this transformation and its distribution among gut microorganisms are poorly ...
Balskus, Emily P, Bess, Elizabeth N, Bisanz, Jordan E, Kiamehr, Sina, Le, Chip, Luescher, Michael U, Maini Rekdal, Vayu, Nol Bernadino, Paola, Turnbaugh, Peter J   +8 more
core   +1 more source

Chiral Assembly Preferences and Directing Effects in Supramolecular Two-Component Organogels [PDF]

, 2018
The impact of chirality on the self-assembly of supramolecular gels is of considerable importance, as molecular-scale programming can be translated into nanostructuring and ultimately affect macroscopic performance.
Edwards, William, Smith, David Kelham
core   +2 more sources

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Addiction, EarlyView.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu, Chia‐Chun Hung, Marc N. Potenza, Kun‐Hsien Chou, Pei‐Lin Lee, Chu‐Chung Huang, Chiang‐Shan R. Li, Tony Szu‐Hsien Lee, Ching‐Po Lin   +8 more
wiley   +1 more source

Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive and Chloroquine-Resistant Plasmodium falciparum [PDF]

, 2015
International audienceThe efficacy of chloroquine, once the drug of choice in the fight against Plasmodium falcipa-rum, is now severely limited due to widespread resistance.
Deregnaucourt, Christiane, Latour, Christine, Lisai, Maryna, Rajapakse, Chandima S. K., Roy, Dipankar, Schrével, Joseph, Sinou, Véronique, Sánchez-Delgado, Roberto A.   +7 more
core   +7 more sources

Merging Micellar Catalysis and C–H Activation: Silver‐Free Direct Arylation of Fluoroarenes in Water

ChemSusChem, Volume 19, Issue 9, 14 May 2026.
We have developed the first silver‐free protocol for a palladium‐catalyzed direct arylation in water under micellar conditions enabling the coupling of diverse pyridine and fluoroarene derivatives. This method combines the sustainability of aqueous media with the efficiency of C–H activation, obviating the need for organic co‐solvents or stoichiometric
Federico Belnome, Kristóf N. Garami, Zoltán Varga, Judith Mihály, Pascal Hauk, Tamás Hergert, György M. Keserű, Fabrice Gallou, Joanna Wencel‐Delord, Péter Ábrányi‐Balogh   +9 more
wiley   +1 more source