Results 71 to 80 of about 2,572 (189)

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

Synthesis and characterization of N-substitutedphenyl -2-(4, 6-dimethoxypyrimidin-2-ylthio) benzylamines(N-取代苯基-2-（4，6-二甲氧基-2-嘧啶硫基）苄胺的合成和表征)

Zhejiang Daxue xuebao. Lixue ban, 2011
以2-巯基苯甲酸、取代苯胺和2-甲砜基-4，6-二甲氧基嘧啶为原料，经酰氯化、酰胺化、还原、亲核取代反应合成了一系列N-取代苯基-2-（4，6-二甲氧基-2-嘧啶硫基）苄胺类化合物，经氢核磁共振光谱、红外光谱、质谱和元素分析确证了它们的结构.
CHENYi-fei(陈一飞), ZHANGPei-zhi(张培志), SUNYan-ping(孙燕萍), WUJun(吴军)   +3 more
doaj   +1 more source

Von Richter Cinnolines Synthesis Revisited—Approach to Polysubstituted Cinnoline Derivatives as Important Scaffolds for Kinase Inhibitors

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
A revised von Richter cyclization of 2‐aminoalkyne precursors enables the synthesis of polysubstituted 4‐halocinnoline derivatives. By addressing the key challenge of hydrolytic instability, this catalyst‐free approach delivers scaffolds amenable to late‐stage C‐4 functionalization.
Krystof Skach, Milan Dejmek, Michal Sala, Radim Nencka   +3 more
wiley   +1 more source

Deactivation Pathways in 2‐Ferrocenylmethyl‐5‐Aminoxazoles Synthesized via Ugi–Zhu Reaction: A Dewar–Chatt–Duncanson‐Type Interaction

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
The synthesis and full characterization are reported of 15 new ferrocenyl‐containing oxazoles via the Ugi–Zhu reaction, which is a special kind of MCR versatile to synthesize different types of heterocycles and polyheterocycles, and the DFT‐based study is performed using a high level of theory to rationalize the reactivity of synthesized compounds ...
Carlos E. Garduño‐Albino, Roberto E. Blanco‐Carapia, Ricardo Alfredo Luna‐Mora, Humberto Laguna‐Galindo, Eduardo González‐Zamora, Alejandro Islas‐Jácome   +5 more
wiley   +1 more source

Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Photo-enabled and thioamide-directed α-C(sp3)–H carboxylation of α-substituted benzylamines with CO2 towards α-tertiary amino acids

Nature Communications
α-Tertiary amino acids (ATAAs) are biologically important molecules that have attracted sustained synthetic interest. However, developing expedient methods for their construction that feature high atom economy and avoid tedious substrate pre ...
Jie Xu, Chang Liu, Chao-Yi Liu, Miao Peng, Yan Zhang, Ding-Hai Wang, Heng Jiang   +6 more
doaj   +1 more source

Synthesis and Structure-Affinity Relationships of Receptor Ligands with 1,3-Dioxane Structure

Pharmaceuticals
Background/Objectives: Ligands blocking σ1 receptors or NMDA receptors show promising pharmacological properties, such as analgesia or neuroprotection.
Elisabeth Quick, Dirk Schepmann, Bernhard Wünsch   +2 more
doaj   +1 more source

Investigations on the Aprotic Deamination of Benzylamine and (alpha,alpha-2H2)Benzylamine. [PDF]

Acta Chemica Scandinavica, 1981
Jan M. Bakke, K. Svendsen, Kjeld Schaumburg, Curt R. Enzell, Curt R. Enzell   +4 more
openaire   +1 more source

Integrated Network Pharmacology Analysis and Experimental Validation to Reveal the Mechanism of Anti-Insulin Resistance Effects of Moringa oleifera Seeds

Drug Design, Development and Therapy, 2020
Qiong Huang,1– 3,* Rong Liu,1– 3,* Jing Liu,1– 3 Qi Huang,1– 3 Shao Liu,1– 3 Yueping Jiang1– 3 1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of China ...
Huang Q, Liu R, Liu J, Huang Q, Liu S, Jiang Y   +5 more
doaj