Results 71 to 80 of about 3,554 (196)

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells

Chemistry – A European Journal, EarlyView.
A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak, Huy N. Hoang, Wael Awad, Xin Yi Lim, Damica D. Laurie, Ryan J. D. Rivero, James McCluskey, Alexandra J. Corbett, Jamie Rossjohn, David P. Fairlie   +9 more
wiley   +1 more source

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Hollow Microporous Organic Networks Bearing Triphenylamines and Anthraquinones: Diffusion Pathway Effect in Visible Light-Driven Oxidative Coupling of Benzylamines

, 2015
Hollow microporous organic networks were prepared by using silica spheres as the template and tris­(4-ethynylphenyl)­amine and 2,6-diiodo-9,10-anthraquinone as the building blocks for the Sonogashira coupling.
Sungah Kang (1535632), Sang Moon Lee (1535614), Nojin Park (1535626), Hee-Won Shin (1565089), Narae Kang (1565086), Ju Hong Ko (1535635), Tae Kyu Ahn (1321374), Seung Uk Son (1535620), Hae Jin Kim (831617)   +8 more
core   +1 more source

Synthesis and characterization of amphiphilic nitroxide 1,1,3,3–tetraethylisoindoline–2–oxyl–5–sodium sulfonate (TEIOSNa)

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract The synthesis and characterization of an amphiphilic nitroxide to be used as a controlling agent in a nitroxide‐mediated living radical polymerization in aqueous dispersion media is presented. In the first stage of nitroxide synthesis (phthalimide protection), two reaction methods were employed: traditional and microwave.
Enrique García‐Leal, Martha Eugenia Albores Velasco, René O. Vargas, Rubén Mil‐Martínez   +3 more
wiley   +1 more source

Synthesis of 4-styrylquinazolines enabled by a hypervalent iodine-promoted oxidative amination cascade

Tetrahedron Chem
Efficient synthetic routes to pharmaceutically important 4-styrylquinazolines scaffolds are of considerable interest. Herein, we report a concise synthesis of 4-styrylquinazoline derivatives via a hypervalent iodine-promoted oxidative amination cascade ...
Lipeng Long, Ziyi Yu, Ziwen Huang, Min Ye, Wenjun Luo, Xunjin Jiang, Zhengwang Chen, Zhong-Xia Wang   +7 more
doaj   +1 more source

AIEE Active Nanoassemblies of Pyrazine Based Organic Photosensitizers as Efficient Metal-Free Supramolecular Photoredox Catalytic Systems

Scientific Reports, 2019
Pyrazine derivatives DIPY, TETPY and CNDIPY have been designed and synthesized which form fluorescent supramolecular assemblies in mixed aqueous media due to their AIEE and ICT characteristics.
Shruti Dadwal, Harnimarta Deol, Manoj Kumar, Vandana Bhalla   +3 more
doaj   +1 more source

Coupling Selective Organic Oxidation With Hydrogen Evolution Over Metal Halide Perovskite Photocatalysts: Halide‐Dependent Design, Mechanisms, and Stability Challenges

EcoEnergy, EarlyView.
This Review highlights how metal halide perovskites enable coupled selective organic oxidation and hydrogen evolution under visible light. It summarizes halide‐dependent design principles, surface engineering strategies, reaction mechanisms, and stability challenges, providing guidance for developing efficient and durable photocatalytic systems ...
Jutarat Jitrada, Lizhen Liu, Patchanita Thamyongkit, Yanfa Yan, Jun Huang   +4 more
wiley   +1 more source

Imidazole synthesis by transition metal free, base-mediated deaminative coupling of benzylamines and nitriles

, 2017
An unprecedented transition metal free, base-mediated deaminative coupling of benzylamines and nitriles is reported. This protocol provides a practical strategy for the synthesis of 2,4,5-tri-substituted imidazoles with liberation of NH3.
Linda J. W. Shimon, Uttam Kumar Das, David Milstein   +2 more
core   +1 more source

NiH-Catalyzed Asymmetric Hydroarylation of N-Acyl Enamines: Practical Access to Chiral Benzylamines [PDF]

, 2020
The enantio- and regioselective reductive hydroarylation of N-acyl enamines has been achieved with a NiH catalyst and a chiral bis-imidazoline ligand.
Yuli, He, Huayue, Song, Shaolin, Zhu
core   +2 more sources

Multidimensional Engineering Enabling Rate‐Matched C−N Coupling for Efficient Organonitrogen Electrosynthesis

EcoEnergy, EarlyView.
This review introduces rate matching as a unifying design principle for efficient electrochemical C−N coupling and highlights multidimensional engineering of catalysts, interfaces, and reactors to synchronize the generation of carbon‐ and nitrogen‐containing intermediates, balance their surface coverages, maximize C−N bond formation, and enable ...
Kaixing Cai, Chunyang Pu, Jun Yang, Guangqin Li, Jiahui Xian   +4 more
wiley   +1 more source