Results 51 to 60 of about 4,788 (230)

Diversity-oriented synthesis of dihydrobenzoxazepinones by coupling the Ugi multicomponent reaction with a Mitsunobu cyclization

Beilstein Journal of Organic Chemistry, 2014
An operationally simple protocol for the synthesis of 2,3-dihydrobenzo[f][1,4]oxazepin-3-ones, based on an Ugi reaction of an ortho-(benzyloxy)benzylamine, glycolic acid, an isocyanide and an aldehyde, followed by an intramolecular Mitsunobu substitution
Lisa Moni, Luca Banfi, Andrea Basso, Alice Brambilla, Renata Riva   +4 more
doaj   +1 more source

Transition metal-mediated synthesis of oxazoles [PDF]

, 2014
Among the synthetic methods for the formation of the oxazole ring, transition metal-mediated protocols are the most attractive in terms of selectivity, efficiency and mildness of reaction conditions.
Bresciani, Stefano, Tomkinson, Nicholas C. O.   +1 more
core   +1 more source

Design and synthesis of 4-nitroimidazole derivatives with potential antitubercular activity

Тонкие химические технологии, 2023
Objectives. To develop the procedures for synthesis of hybrid molecules with potential anti-tubercular activity containing heterocyclic cores of 4-nitroimidazole and 1,3,4-thiadiazole within the framework of a double-drug strategy and predict bioactivity
T. S. Vedekhina, M. V. Chudinov, A. Yu. Lukin   +2 more
doaj   +1 more source

Highly efficient oxidation of amines to aldehydes via flow-based biocatalysis [PDF]

, 2017
A new mild and efficient process for the preparation of aldehydes in water employed as flavour and fragrance components in food, beverage, cosmetics, as well as in pharmaceuticals was developed using a continuous-flow approach based on an immobilized ...
Akhtar, Allen, Andrade, Babich, Bajic, Bolivar, Bryan, Buckley, Calleri, Carvalho, Cerioli, Csajági, Dall′Oglio, Desjardins, Díaz-Rodríguez, Falus, Finnigan, Galletti, Hacisalihoglu, Hamamoto, Hu, Itabaiana, Junior, Kantlehner, Knowles, Kunjapur, Largeron, Largeron, Lawrence, Ley, Liu, Matsuo, Molinari, Noureldin, Orito, Planchestainer, Plouffe, Romano, Schümperli, Sharma, Sheldon, Smith, Solomon, Tamborini, Tamborini, Turner, Wang, Wiles, Yoshida, Zambelli, Zambelli, Zheng   +51 more
core   +2 more sources

Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines [PDF]

, 2014
An unprecedented NH2-directed Pd(II)-catalytic carbonylation of quaternary aromatic α -amino esters to yield 6-membered 10 benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones.
Albert Mach, Joan, Ariza Piquer, Xavier, García Gómez, Jordi, Granell Sanvicente, Jaime Ramón, López Barallobre, Blanca, Rodríguez Ramírez, Aleix, Santos, David   +6 more
core   +1 more source

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie International Edition, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +1 more source

Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis. [PDF]

, 2012
Esters of 1,4-benzoxazine and 1,4-benzodioxine compounds 1 and 10, which combine thrombin inhibitory and GPIIb/IIIa antagonistic activity in one molecule are shown to inhibit endothelial cell migration and tube formation in vitro and angiogenesis in the ...
Andrej Boháč, Arnaoutova, Auerbach, Carmeliet, Caunt, Crawford, Cristofanilli, Danijel Kikelj, Ebos, Ferrara, Ferro, Folkman, Ilaš, Ilić, Ilić, Janez Ilaš, Khachigian, Liekens, Miloš Ilić, Nierodzik, Nierodzik, Pennacchietti, Petra Dunkel, Prins, Pàez-Ribes, Péter Mátyus, Rhee, Sabrkhany, Samant, Sandra Liekens, Sleeman, Sorensen, Staton, Steeg, Tsopanoglou, Tsopanoglou, Štefanič Anderluh   +36 more
core   +1 more source

Deaminative coupling of benzylamines and arylboronic acids

Chemical Science, 2023
A metal-free deaminative coupling of non-prefunctionalised benzylamines and arylboronic acids is reported.
Giedre Sirvinskaite, Julia C. Reisenbauer, Bill Morandi   +2 more
openaire   +3 more sources

Palladium and Platinum 2,4-cis-amino Azetidine and Related Complexes [PDF]

, 2018
Seven N,N’-palladium(II) chloride complexes, one N,N’-palladium(II) acetate complex of 2,4-cis-azetidines where prepared and analyzed by single crystal XRD.
Binder, Choi, Clavier, Coles, Falivene, Feula, Feula, Feula, Fossey, Fossey, Fossey, Fossey, Fossey, Fossey, Gaertner, Graham, Hama Salih, Hambley, Jamieson, Keller, Lee, Lee, Lee, Leonard, Martínez-Olid, Payne, Pelz, Pelz, Poater, Rixe, Saito, Voureka, Yoshizawa, Yoshizawa, Yoshizawa, Álvarez-Casao   +35 more
core   +5 more sources

Enantiopure Ferrocene-Based Planar-Chiral Iridacycles:Stereospecific Control of Iridium-Centred Chirality [PDF]

, 2016
Reaction of [IrCp*Cl-2](2) with ferrocenylimines (Fc=NAr, Ar=Ph, p-MeOC6H4) results in ferrocene C-H activation and the diastereoselective synthesis of half-sandwich iridacycles of relative configuration S-p*,R-Ir*.
Albrecht, Alezra, Arita, Arita, Barloy, Barnard, Bauer, Bauer, Beck, Berger, Boutadla, Brunner, Crestani, Djukic, Djukic, Djukic, Djukic, Djukic, Djukic, Dunina, Faller, Féghali, Garner, Gleiter, Gokel, Günay, Han, Hay, Hill, Huang, Hull, Huo, Jablonskyte, Jerphagnon, Kashiwame, Kerber, Koch, Kreindlin, Kuklin, Li, Liu, Lupan, López, López, Massue, Newbound, Nishibayashi, Nomura, Oertel, Osborne, Oxgaard, Pannetier, Perera, Richards, Richards, Richards, Richards, Ruiz, Ryabov, Sammakia, Schaarschmidt, Scheeren, Scheibitz, Sortais, Talwar, Tao, Tenn, Ueng, Valk, Wadt, Wang, Wang, Watanabe, Weiss, Wu, Wu, Xia, Zdanovich, Škvorcová   +78 more
core   +1 more source