Results 21 to 30 of about 15,581 (231)
Targeting Cancer Cells with BET Bromodomain Inhibitors [PDF]
Cold Spring Harbor Perspectives in Medicine, 2017 Cancer cells are often hypersensitive to the targeting of transcriptional regulators, which may reflect the deregulated gene expression programs that underlie malignant transformation. One of the most prominent transcriptional vulnerabilities in human cancer to emerge in recent years is the bromodomain and extraterminal (BET) family of proteins, which ...
Yali, Xu, Christopher R, Vakoc
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Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation
Epigenetics & Chromatin, 2020 Background Pharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer.
Archit Trivedi +9 more
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BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1 [PDF]
, 2013 The bromodomain and extra terminal (BET) family protein bromodomain containing protein 4 (BRD4) is an epigenetic regulator recently identified as a therapeutic target for several hematological cancers, notably mixed lineage leukemia-fusion acute myeloid ...
Bastow, Sarah +3 more
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Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer [PDF]
, 2014 Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. BET bromodomain inhibitors, which have shown efficacy in several models of cancer have not been evaluated in TNBC.
Anders, Lars +39 more
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Stem Cell Research, 2016 Neural stem cells and progenitor cells (NPCs) are increasingly appreciated to hold great promise for regenerative medicine to treat CNS injuries and neurodegenerative diseases.
Jingjun Li +14 more
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Nejire/dCBP-mediated control of H3 acetylation and transcriptional regulation by testis-specific Plus3 domain proteins during Drosophila spermatogenesis [PDF]
, 2018 Spermatogenesis describes the development from germ line stem cells to highly specialized sperm. Drosophila melanogaster spermatogenesis is a good model system for chromatin remodelling processes as many of these processes are similar in mammals and in ...
Hundertmark, Tim
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BET bromodomain protein inhibition is a therapeutic option for medulloblastoma [PDF]
, 2013 Medulloblastoma is the most common malignant brain tumor of childhood, and represents a significant clinical challenge in pediatric oncology, since overall survival currently remains under 70%.
Althof, Kristina +13 more
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Nature Communications, 2023 Bromodomain and extraterminal proteins (BET) are reported as targets for anticancer therapy. Here, the authors report the final results of a phase I clinical trial of the BET inhibitor trotabresib in patients with solid tumours and diffuse large B-cell ...
Victor Moreno +20 more
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BET-ting on bromodomains [PDF]
Science-Business eXchange, 2010 A team led by the Dana-Farber Cancer Institute and the Structural Genomics Consortium has identified a selective inhibitor of bromodomains—protein domains that bind and recognize histone acetylation—and has shown its activity in a preclinical model of a rare cancer.
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BET bromodomain inhibition suppresses TH17-mediated pathology [PDF]
Journal of Experimental Medicine, 2013 Interleukin (IL) 17–producing T helper (TH17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation and activation results in autoimmune conditions.
Mele, Deanna A. +5 more
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