Results 261 to 270 of about 24,956 (275)

Naphthyridines as Novel BET Family Bromodomain Inhibitors

ChemMedChem, 2013
AbstractBromodomains (BRDs) are small protein domains found in a variety of proteins that recognize and bind to acetylated histone tails. This binding affects chromatin structure and facilitates the localisation of transcriptional complexes to specific genes, thereby regulating epigenetically controlled processes including gene transcription and mRNA ...
Olivier, Mirguet, Yann, Lamotte, Chun-Wa, Chung, Paul, Bamborough, Delphine, Delannée, Anne, Bouillot, Françoise, Gellibert, Gael, Krysa, Antonia, Lewis, Jason, Witherington, Pascal, Huet, Yann, Dudit, Lionel, Trottet, Edwige, Nicodeme   +13 more
openaire   +2 more sources

BET inhibitors in cancer therapeutics: a patent review

Expert Opinion on Therapeutic Patents, 2016
Inhibition of Bromodomain and Extra Terminal (BET) proteins is an emerging approach for developing advanced cancer therapeutics. In 2015, at least thirty patents have been published for developing cancer chemotherapeutics by targeting BET. Currently there are seven small molecule BET inhibitors in various stages of clinical trials for the development ...
Anirban, Ghoshal, D, Yugandhar, Ajay Kumar, Srivastava   +2 more
openaire   +2 more sources

Selective N‐Terminal BET Bromodomain Inhibitors by Targeting Non‐Conserved Residues and Structured Water Displacement**

Angewandte Chemie - International Edition, 2021
Huarui Cui, Anand Divakaran, Anil K Pandey   +2 more
exaly  

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

Molecular Cell, 2020
Jennifer Y Ge, Rhamy Zeid, Isaac S Harris   +2 more
exaly  

Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections

Proceedings of the National Academy of Sciences of the United States of America, 2022
Zhifeng Yu, Kiran L Sharma, Pranavanand Nyshadham   +2 more
exaly  

A BET inhibitor workaround

Nature Chemical Biology, 2016
openaire   +1 more source

Progress in the development of domain selective inhibitors of the bromo and extra terminal domain family (BET) proteins

European Journal of Medicinal Chemistry, 2021
Haiying Sun
exaly  

Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors

ACS Medicinal Chemistry Letters, 2013
Michael C Hewitt, Alexandre Coté, Christopher G Nasveschuk   +2 more
exaly  

Current status in the discovery of dual BET/HDAC inhibitors

Bioorganic and Medicinal Chemistry Letters, 2021
exaly  

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

Nature, 2016
Charles Y Lin, Housheng Hansen He, Robert M Witwicki   +2 more
exaly