Results 81 to 90 of about 56,924 (160)

BRD4 inhibition suppresses histone H4 UFMylation to increase ferroptosis sensitivity through TXNIP

Cell Death and Disease
Bromodomain Containing 4 (BRD4) inhibition selectively alters gene transcription, which subsequently influences cellular responses to BET inhibitors.
Zhen Yang, Baoshuai Wang, Bin Guo, Shimin Sun, Yishen Li, Jingbo Lu, Xuejun Cao, Hao Wang, Xinyu Wang, Yongjian Guo, Tao Wu   +10 more
doaj   +1 more source

Identification of targetable epigenetic vulnerabilities for uveal melanoma

Cell Death and Disease
Uveal melanoma (UM) is the most common adult primary intraocular malignancy, with a strong predilection for hepatic metastasis, occurring in approximately 50% of cases. Metastatic UM is highly resistant to therapy and is almost invariably fatal.
Gulum Yenisehirli, Sebastian Borges, Steffanie S. Braun, Ashley N. Zuniga, Gabriela I. Quintana, Jeffim N. Kutsnetsoff, Renata L. Volonterio, Sara Rodriguez, Emily V. Adis, Sofia Lopez, James J. Dollar, Vasileios Stathias, Claude-Henry Volmar, Efe Karaca, Shaun P. Brothers, Daniel Bilbao, J. William Harbour, Zelia M. Correa, Stefan Kurtenbach   +18 more
doaj   +1 more source

BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma

The Journal of Clinical Investigation
Diffuse midline glioma (DMG) H3K27-altered is one of the most malignant childhood cancers. Radiation therapy remains the only effective treatment yet provides a 5-year survival rate of only 1%.
Jun Watanabe, Matthew R. Clutter, Michael J. Gullette, Takahiro Sasaki, Eita Uchida, Savneet Kaur, Yan Mo, Kouki Abe, Yukitomo Ishi, Nozomu Takata, Manabu Natsumeda, Samantha Gadd, Zhiguo Zhang, Oren J. Becher, Rintaro Hashizume   +14 more
doaj   +1 more source

BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition. [PDF]

Mil Med Res, 2023
Meng Y, Sun HY, He Y, Zhou Q, Liu YH, Su H, Yin MZ, Zeng FR, Chen X, Deng GT.   +9 more
europepmc   +1 more source

FOXD3 Regulates VISTA Expression in Melanoma. [PDF]

, 2020
Immune checkpoint inhibitors have improved patient survival in melanoma, but the innate resistance of many patients necessitates the investigation of alternative immune targets.
Aplin, Andrew E., Berger, Adam C., Chervoneva,, Davies, Michael A., Erkes, Dan A., Fisher, David E., Gershenwald, Jeffrey E., Knecht, Meghan, Lo, Jennifer A., McCue, Peter A., Mollaee, Mehri, Purwin, Timothy J., Rosenbaum, Sheera R., Zhong, Zhijiu   +13 more
core   +1 more source

Loci specific epigenetic drug sensitivity. [PDF]

, 2020
Therapeutic targeting of epigenetic modulators offers a novel approach to the treatment of multiple diseases. The cellular consequences of chemical compounds that target epigenetic regulators (epi-drugs) are complex.
Pilko, Anna, Wollman, Roy, Zhang, Thanutra   +2 more
core   +1 more source

Cytoprotective, Cytotoxic and Cytostatic Roles of Autophagy in Response to BET Inhibitors. [PDF]

Int J Mol Sci, 2023
Elshazly AM, Gewirtz DA.
europepmc   +1 more source

Current landscape of BRD4 inhibitors: Selective targeting and protein degradation for enhanced efficacy

Results in Chemistry
The bromodomain and extra-terminal domain (BET) family of proteins has been implicated as a crucial factor in the pathogenesis of numerous diseases by regulating gene expression and chromatin dynamics through its bromodomains, which bind to acetylated ...
Linlin Deng, Erkang Tian, Ting Ma, Shaojie Liang, Sijia Hu, Linwei Li, Juan Li   +6 more
doaj   +1 more source

Recent progress and structural analyses of domain-selective BET inhibitors. [PDF]

Med Res Rev, 2023
Divakaran A, Harki DA, Pomerantz WCK.
europepmc   +1 more source

"Billion Dollar Bets" to Create Economic Opportunity for Every American [PDF]

, 2016
The American Dream--the notion that if you "work hard and play by the rules," you will improve your lot in life--has become impossible for Americans to achieve.
Debby Bielak, Devin Murphy, Jim Shelton
core