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Targeting BET bromodomain proteins in cancer: The example of lymphomas
Pharmacology & Therapeutics, 2020 The Bromo- and Extra-Terminal domain (BET) family proteins act as "readers" of acetylated histones and they are important transcription regulators. BRD2, BRD3, BRD4 and BRDT, part of the BET family, are important in different tumors, where upregulation ...
Francesco Bertoni +2 more
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Role of bromodomain and extraterminal (BET) proteins in prostate cancer
Expert Opinion on Investigational Drugs, 2023The bromodomain and extraterminal (BET) family of proteins are epigenetic readers of acetylated histones and are critical activators of oncogenic networks across many cancers. Therapeutic targeting of BET proteins has been an attractive area of clinical development for metastatic castration-resistant prostate cancer.
Adel Mandl +3 more
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Small-Molecule Targeting of BET Proteins in Cancer
2016BET proteins have recently become recognized for their role in a broad range of cancers and are defined by the presence of two acetyl-histone reading bromodomains and an ET domain. This family of proteins includes BRD2, BRD3, BRD4, and BRDT. BRD4 is the most-studied BET protein in cancer, and normally serves as an epigenetic reader that links active ...
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Investment in Cancer Control and Research: A Sure Betâ€
Ca-A Cancer Journal for Clinicians, 2006Carolyn D Runowicz
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