Results 91 to 100 of about 61,745 (283)

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns [PDF]

, 2016
© 2014 Elsevier B.V. G protein-coupled receptor kinase 2 (GRK2) has recently emerged as a negative modulator of insulin signaling. GRK2 downregulation improves insulin sensitivity and prevents systemic insulin resistance.
Jurado-Pueyo, María, Lucas, Elisa, Mayor Menéndez, Federico, Murga, Cristina, Vila-Bedmar, Rocío   +4 more
core   +1 more source

Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling [PDF]

, 2022
Bénédicte Rousseau, Sengottuvelan Murugan, Ajay Palagani, Dipak K. Sarkar   +3 more
openalex   +1 more source

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Medicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang   +3 more
wiley   +1 more source

Labor-associated gene expression in the human uterine fundus, lower segment, and cervix [PDF]

, 2006
Background Preterm labor, failure to progress, and postpartum hemorrhage are the common causes of maternal and neonatal mortality or morbidity. All result from defects in the complex mechanisms controlling labor, which coordinate changes in the ...
Aguan, Bethin, Blanks, Bonnar, Brenninkmeijer, Challis, Challis, Chan, Elliott, Garland D Anderson, Gary D. V Hankins, George R Saade, Girotti, Gottwald, Griffith, Lee, Lorenz, Montano, Nathanielsz, Nathanielsz, Nicholas Fisk, Norwitz, Panaro, Phillippe, Radek Bukowski, Schmid, Slater, Sparey, Steven Thornton, Stuart, Suarez, Tavazoie, Teoh, Thomas, Thota, Tribe, Wathes, Wolfe   +37 more
core   +3 more sources

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, EarlyView.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis [PDF]

, 2011
hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors).
Alyn H. Morice, Andrew Botham, Bijlmakers, Blanpain, Bockaert, Bockaert, Bohm, Carvou, Compton, Compton, Compton, DeFea, Dery, Doi, Eason, Escriba, Hansen, Hawtin, Hayashi, Heuser, Jiang, Kawate, Klinger, Krasel, Krupnick, Kumar, Lafleur, Laura R. Sadofsky, Ma, McCoy, Melkonian, Moffett, Moffett, Molino, Moore, Munshi, Oh, Okamoto, Okamoto, Palmer, Percherancier, Petaja-Repo, Piersen, Ponimaskin, Qanbar, Rimoldi, Sadeghi, Seatter, Shenoy, Stalheim, Steven J. Compton, Wei, Xiaodan Guo, Yu Pei Xiao, Zoudilova   +54 more
core   +3 more sources

Expanding the Reach of Membrane Protein–Ligand Interaction Studies Through the Integration of Mass Spectrometry and Membrane Mimetics

PROTEOMICS, EarlyView.
ABSTRACT Mass spectrometry (MS) offers robust, label‐free approaches for characterizing ligand–protein interactions through two main strategies: affinity‐based and stability‐based assays. However, their application to membrane proteins (MPs)—a major class of drug targets—has been limited by challenges such as structural complexity, low native ...
Jonathon C. Lambos, Ashim Bhattacharya, Mohammed Al‐Seragi, Franck Duong van Hoa   +3 more
wiley   +1 more source

Role of the nervous system in cancer metastasis [PDF]

, 2018
Cancer remains as one of the leading cause of death worldwide. The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role.
Apostolopoulos, Vasso, Kuol, Nyanbol, Nurgali, Kulmira, Stojanovska, Lily   +3 more
core   +3 more sources

Acaricidal activity of small molecule antagonists of the tick kinin receptor against Rhipicephalus microplus acaricide‐susceptible and resistant strains

Pest Management Science, EarlyView.
Two small molecules, SACC‐0039590 and SACC‐0428788, killed cattle fever tick, R. microplus, susceptible Deutch strain and pyrethroid resistant Arauquita strain larvae. SACC‐0039590 at 1 mM decreased the reproductive parameters of Deutch females. Abstract BACKGROUND Resistance to acaricides underscores the need for tick control alternatives.
Waleed M. Arafa, Kimberly H. Lohmeyer, Patricia V. Pietrantonio   +2 more
wiley   +1 more source