Results 111 to 120 of about 8,484 (124)
Uridine, a Therapeutic Nucleoside, Exacerbates Alcoholic Liver Disease via SRC Kinase Activation: A Network Toxicology and Molecular Dynamics Perspective. [PDF]
Int J Mol SciLiu Z, Wang Z, Wang J, Xu S, Zhang T.
europepmc +1 more source
Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase [PDF]
Biochemistry, 1989 Previous studies have demonstrated that muscarinic cholinergic receptors (mAChR) become markedly phosphorylated when intact cardiac cells are stimulated with a muscarinic agonist. This process appears to be related to the process of receptor desensitization. However, the mechanism of agonist-induced phosphorylation of mAChR is not known.
Robert J. Lefkowitz +4 more
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Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase [PDF]
Biochemistry, 1991 The beta-adrenergic receptor kinase (beta-ARK) phosphorylates G protein coupled receptors in an agonist-dependent manner. Since the exact sites of receptor phosphorylation by beta-ARK are poorly defined, the identification of substrate amino acids that are critical to phosphorylation by the kinase are also unknown.
John W. Regan +5 more
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American Journal of Physiology-Heart and Circulatory Physiology, 1997
To determine the direct functional significance of the beta-adrenergic receptor (AR) kinase 1 (beta ARK1) on myocardial performance in the absence of tonic sympathoadrenal neural activation and mechanical loading, we measured the contractile responses to acute beta 1-AR stimulation in left ventricular myocytes isolated from nontransgenic control (NTG)
Donna H. Korzick +5 more
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To determine the direct functional significance of the beta-adrenergic receptor (AR) kinase 1 (beta ARK1) on myocardial performance in the absence of tonic sympathoadrenal neural activation and mechanical loading, we measured the contractile responses to acute beta 1-AR stimulation in left ventricular myocytes isolated from nontransgenic control (NTG)
Donna H. Korzick +5 more
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β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
Science, 1989The β-adrenergic receptor kinase (β-ARK), which specifically phosphorylates only the agonist-occupied form of the β-adrenergic and closely related receptors, appears to be important in mediating rapid agonist-specific (homologous) desensitization.
Benovic JL +4 more
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Biochemical and Biophysical Research Communications, 1993
In the present study the cDNA of human beta ARK2 was cloned using both PCR and cDNA library screening, subcloned into an expression vector and transiently expressed in COS7 cells. The expressed kinase activity was approximately 40% as efficient as human beta ARK1 in phosphorylating bovine rod outer segments in vitro. Northern blot analysis of human and
Parruti G +3 more
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In the present study the cDNA of human beta ARK2 was cloned using both PCR and cDNA library screening, subcloned into an expression vector and transiently expressed in COS7 cells. The expressed kinase activity was approximately 40% as efficient as human beta ARK1 in phosphorylating bovine rod outer segments in vitro. Northern blot analysis of human and
Parruti G +3 more
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The β-adrenergic receptor kinase in heart failure
Journal of Molecular and Cellular Cardiology, 2003Heart failure (HF) remains a significant and increasing cause of worldwide morbidity and mortality. HF is less a disease than a common clinical endpoint resulting from diverse, but often co-existing etiologies-including hypertension, coronary artery disease, and viral cardiomyopathy.
Walter J. Koch, Jason A. Petrofski
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Psychiatry Research, 2004
Chromosome 22q12 is one of the most promising regions for harboring a risk gene for schizophrenia. We have reported significant linkage of intermediate phenotypes for schizophrenia with markers within or near the beta-adrenergic receptor kinase 2 (ADRBK2, or GRK3) gene, which is highly expressed in dopaminergic pathways in the central nervous system ...
Yoichi Fukura +14 more
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Chromosome 22q12 is one of the most promising regions for harboring a risk gene for schizophrenia. We have reported significant linkage of intermediate phenotypes for schizophrenia with markers within or near the beta-adrenergic receptor kinase 2 (ADRBK2, or GRK3) gene, which is highly expressed in dopaminergic pathways in the central nervous system ...
Yoichi Fukura +14 more
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beta-Adrenergic-receptor kinase [PDF]
, 1997 Dietmar Schomburg, Dörte Stephan
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