Results 141 to 150 of about 61,745 (283)
The FASEB Journal, Volume 39, Issue 19, 15 October 2025.DHI attenuates RIHD by inhibiting ferroptosis. It upregulates GPX4 and SLC7A11 while downregulating TFR1 and HO‐1, thereby reducing lipid peroxidation and oxidative stress to preserve mitochondrial integrity and cardiac function. ABSTRACT Radiation‐induced heart disease (RIHD) has garnered increasing clinical attention.
Bo‐wen Wang +6 more
wiley +1 more source
FEBS Open Bio, Volume 15, Issue 10, Page 1570-1584, October 2025.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
FEBS Open Bio, Volume 15, Issue 10, Page 1643-1657, October 2025.Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu +9 more
wiley +1 more source
Advanced Materials, Volume 37, Issue 41, October 16, 2025.This novel 3D human ischemic heart‐on‐a‐chip, with perfusable vasculature directly interfaced with myocardial tissue, replicates key aspects of ischemic heart injury. It also demonstrates the targeted delivery and therapeutic efficacy of cardiac homing peptide‐conjugated liposomes, validating the platform for drug and nanomedicine screening in ...
Junyoung Kim +14 more
wiley +1 more source
Advanced Science, Volume 12, Issue 37, October 6, 2025.Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang +6 more
wiley +1 more source
Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm. [PDF]
InflammopharmacologyGhosn A +5 more
europepmc +1 more source
Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy
Advanced Science, Volume 12, Issue 38, October 13, 2025.This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan +4 more
wiley +1 more source