Results 151 to 160 of about 28,675 (270)

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun   +16 more
wiley   +1 more source

Therapeutic Potential of the β3-Adrenergic Receptor and Its Ligands in Cardiovascular Diseases. [PDF]

open access: yesInt J Mol Sci
Kempiński M   +6 more
europepmc   +1 more source

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

open access: yesAdvanced Science, Volume 13, Issue 3, 14 January 2026.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan   +12 more
wiley   +1 more source

Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.

open access: hybrid, 1992
Martin J. Lohse   +7 more
openalex   +1 more source

The Interface of Oral and Brain Health: Current Insights Into the Bidirectional Relationship Between Alzheimer's Disease and Periodontitis

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Bidirectional Pathogenesis Between AD and Periodontitis. Periodontal pathogens reach the brain via hematogenous/trigeminal/oral–intestinal pathways, triggering neuroinflammation and Aβ plaques to drive AD. Conversely, AD disrupts bone homeostasis (via Aβ, endocrine/autonomic dysregulation) to aggravate periodontitis.
Weidong Zhang   +5 more
wiley   +1 more source

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei   +11 more
wiley   +1 more source

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