Results 81 to 90 of about 10,759 (223)

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Sildenafil: A Beta-2 Adrenergic Receptor-, Protein Kinase G-, and Protein Kinase A-Dependent Treatment for Adverse Cardiac Function and Excitation-Contraction Coupling Associated with Diabetes [PDF]

, 2018
Toni M. West, Qingtong Wang, Yongming Wang, Federica Barbagallo, Dana Chen, Yang K. Xiang   +5 more
openalex   +1 more source

Oxygen and glucose supplementation increases rates of linear growth and cell proliferation in growth‐restricted fetal sheep

The Journal of Physiology, EarlyView.
Abstract figure legend Effects of sustained oxygen and glucose supplementation on growth and cellular proliferation in growth‐restricted fetuses. This study evaluated whether supplemental oxygen and glucose could improve growth rates in sheep fetuses with established fetal growth restriction (FGR). Following the induction of placental insufficiency and
Mariangel Varela, Daniel B. Chrisenberry, Eliza H. Johnson, Rosa I. Luna‐Ramirez, Ayna R. Tracy, Sanya Kathuria, Weicheng Zhao, Miranda J. Anderson, Laura D. Brown, Sean W. Limesand   +9 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Myocardial toxicity in two dogs with natural exposure to ractopamine

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract Two dogs that lived in a farm setting were presented to the Texas A&M University Veterinary Medical Teaching Hospital's Emergency Service exhibiting muscle tremors and ventricular arrhythmias following ingestion of ractopamine, a ß‐2 agonist feed‐additive used in beef cattle, pigs and turkeys intended for slaughter to increase muscle mass. The
Sophie Tippit, Igor Yankin, Molly Wart, Sonya Wesselowski   +3 more
wiley   +1 more source

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

, 1985
Jeffrey Benovic, Linda J. Pike, Richard A. Cerione, C Staniszewski, T Yoshimasa, Juan Codina, Marc G. Caron, Robert J. Lefkowitz   +7 more
openalex   +1 more source

Sex‐Dependent Effects of Angiotensin II and Calcineurin in the Vasculature of Mice

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim Cardiovascular diseases display strong sex differences. Angiotensin II (AngII) is implicated in this process. The ubiquitously expressed enzymatic beta subunit of calcineurin (PPP3CB), a serine/threonine phosphatase, can mediate pathological effects of AngII in the heart.
Alexander Nolze, Sindy Rabe, Stefanie Ruhs, Nicole Strätz, Katja Quarch, Conny Köhler, Claudia Grossmann   +6 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes

, 2018
Shangyu Hong, Wei Song, Peter‐James H. Zushin, Bingyang Liu, Mark P. Jedrychowski, Amir I. Mina, Zhaoming Deng, Dimitrije Čabarkapa, Jessica A. Hall, Colin J. Palmer, Hassan Aliakbarian, John Szpyt, Steven P. Gygi, Ali Tavakkoli, Lydia Lynch, Norbert Perrimon, Alexander S. Banks   +16 more
openalex   +2 more sources

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source