Results 201 to 210 of about 174,626 (254)

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

High yield production of 3-hydroxypropionic acid using Issatchenkia orientalis. [PDF]

Nat Commun
Tan SI, Bhagwat SS, Martin TA, Suthers PF, Tran VG, Tang W, Fatma Z, Maranas CD, Guest JS, Zhao H.   +9 more
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Amino acids: Missing link in preeclampsia pathogenesis? [PDF]

Eur J Nutr
Gezer IS, Altinsoy H, Bastemur AG, Dogan O, Tanacan A, Ocal FD, Sahin D, Yazihan N.   +7 more
europepmc   +1 more source

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, EarlyView.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Multi-Omics Reveals Dysregulation of the Endosome-Lysosome-Autophagy Axis and Immune-Inflammatory Imbalance in Elderly Sepsis. [PDF]

Clin Interv Aging
Gou Y, Xia Z, Haireti N, Aikepaer A, Yang J, Li D.   +5 more
europepmc   +1 more source

Metagenomic profiling and predictive modeling of the gut microbiome reveal signatures of gestational disease. [PDF]

Microbiol Spectr
Mortensen GA, Schmidt H, Radivojac P, Ye Y, Haas DM.   +4 more
europepmc   +1 more source

Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts. [PDF]

Metabolomics
Terra C, Terrier O, Le Gouellec A.
europepmc   +1 more source

25-Hydroxyvitamin D₃ supplementation improves growth performance and alleviates weaning stress in calves by modulating intestinal microbiota and metabolic pathways. [PDF]

Front Microbiol
Zhu W, Liu X, Hu S, Feng B, Li Y, Li X, Ma F, Li J, Gao Y, Xu H.   +9 more
europepmc   +1 more source

Physical Activity and Metabolic Alterations in Children and Adolescents Across Different Weight Groups: A Systematic Review. [PDF]

Eur J Sport Sci
Leppänen MH, Hintikka JE, Wijnant K, Haapala EA, Lakka TA, Vanhaecke L, Viljakainen H.   +6 more
europepmc   +1 more source