Results 1 to 10 of about 1,364,431 (182)

Production of 3-Hydroxypropionic Acid from Renewable Substrates by Metabolically Engineered Microorganisms: A Review [PDF]

Molecules, 2023
3-Hydroxypropionic acid (3-HP) is a platform chemical with a wide range of existing and potential applications, including the production of poly(3-hydroxypropionate) (P-3HP), a biodegradable plastic.
Xiaodi Wang, Zhenzhen Cui, Xi Sun, Zhiwen Wang, Tao Chen   +4 more
doaj   +5 more sources

Promoter engineering for enhanced 3-hydroxypropionic acid production in Pichia pastoris [PDF]

Synthetic and Systems Biotechnology
Enabling tools are essential for facilitating the methanol bioconversion in Pichia pastoris. However, there is still a relative lack of promoters that can stably express high levels without being affected by the carbon source, which hinders the ...
Shushu Chen, Mengyao Zhang, Xiaoyan Wu, Fan Bai, Linhui Gao, Yiwei Shen, Shaohua Dou, Peng Cai, Yongjin J. Zhou   +8 more
doaj   +3 more sources

High yield production of 3-hydroxypropionic acid using Issatchenkia orientalis [PDF]

Nature Communications
Biomanufacturing provides a more sustainable alternative to fossil-based chemical manufacturing. 3-Hydroxypropionic acid (3HP) is a top Department of Energy value-added chemical and precursor to bioplastics, yet cost-effective microbial production ...
Shih-I Tan, Sarang S. Bhagwat, Teresa A. Martin, Patrick F. Suthers, Vinh G. Tran, Wuying Tang, Zia Fatma, Costas D. Maranas, Jeremy S. Guest, Huimin Zhao   +9 more
doaj   +3 more sources

Metabolic engineering of Komagataella phaffii for enhanced 3-hydroxypropionic acid (3-HP) production from methanol [PDF]

Journal of Biological Engineering
Background Bioconversion of methanol derived from CO2 reduction into value-added chemicals provides a unique approach for mitigating global warming and reducing fossil fuels dependence.
Sílvia Àvila-Cabré, Joan Albiol, Pau Ferrer   +2 more
doaj   +3 more sources

Biocatalytic production of 3-hydroxypropionic acid precursors using a regioselective Baeyer-Villiger monooxygenase [PDF]

Scientific Reports
Baeyer-Villiger monooxygenases (BVMOs) are versatile biocatalysts that catalyse the oxidation of ketones to esters with high regio- and enantioselectivity, operating under mild reaction conditions while reducing hazardous waste.
Melissa De Angelis, Danilo Correddu, Fabio Bucciol, Silvia Tabasso, Gianluca Catucci, Giancarlo Cravotto, Carlo Roggero, Gianfranco Gilardi, Sheila J. Sadeghi   +8 more
doaj   +3 more sources

Enhancing 3-hydroxypropionic acid production from recombinant Saccharomyces cerevisiae for using rice straw hydrolysate and sugar cane industrial waste as substrate [PDF]

Synthetic and Systems Biotechnology
Rice straw and sugar cane industrial waste are a plentiful source of lignocellulosic biomass with a high polysaccharide content, that is hydrolyzed into sugar for microbial growth and their metabolites.
Supattra Lertsriwong, Phatcharaphong Khaosaart, Nassapat Boonvitthya, Warawut Chulalaksananukul, Chompunuch Glinwong   +4 more
doaj   +3 more sources

Increased CO2 fixation enables high carbon-yield production of 3-hydroxypropionic acid in yeast [PDF]

Nature Communications
CO2 fixation plays a key role to make biobased production cost competitive. Here, we use 3-hydroxypropionic acid (3-HP) to showcase how CO2 fixation enables approaching theoretical-yield production.
Ning Qin, Lingyun Li, Xiaozhen Wan, Xu Ji, Yu Chen, Chaokun Li, Ping Liu, Yijie Zhang, Weijie Yang, Junfeng Jiang, Jianye Xia, Shuobo Shi, Tianwei Tan, Jens Nielsen, Yun Chen, Zihe Liu   +15 more
doaj   +3 more sources

Engineering 3-Hydroxypropionic Acid Production from Glucose in Yarrowia lipolytica through Malonyl-CoA Pathway [PDF]

Journal of Fungi, 2023
3-Hydroxypropionic acid (3-HP) is an important intermediate compound in the chemical industry. Green and environmentally friendly microbial synthesis methods are becoming increasingly popular in a range of industries.
Shiyu Liu, Yao Sun, Tianhui Wei, Dianliang Gong, Qi Wang, Zhe Zhan, Jinzhu Song   +6 more
doaj   +3 more sources

Engineering Corynebacterium glutamicum for the efficient production of 3-hydroxypropionic acid from glucose via the β-alanine pathway [PDF]

Synthetic and Systems Biotechnology
3-Hydroxypropionic Acid (3-HP) is recognized as a high value-added chemical with a broad range of applications. Among the various biosynthetic pathways for 3-HP production, the β-alanine pathway is particularly noteworthy due to its capacity to generate ...
Xiaodi Wang, Junyuan Hou, Jieyao Cui, Zhiwen Wang, Tao Chen   +4 more
doaj   +3 more sources

Combining Metabolic Engineering and Multiplexed Screening Methods for 3-Hydroxypropionic Acid Production in Pichia pastoris [PDF]

Frontiers in Bioengineering and Biotechnology, 2022
Production of 3-hydroxypropionic acid (3-HP) in Pichia pastoris (syn. Komagataella phaffii) via the malonyl-CoA pathway has been recently demonstrated using glycerol as a carbon source, but the reported metrics were not commercially relevant.
Albert Fina, Stephanie Heux, Joan Albiol, Pau Ferrer   +3 more
doaj   +3 more sources