Results 21 to 30 of about 1,364,431 (182)

One stone two birds: Biosynthesis of 3-hydroxypropionic acid from CO2 and syngas-derived acetic acid in Escherichia coli [PDF]

Synthetic and Systems Biotechnology, 2021
Syngas, which contains large amount of CO2 as well as H2 and CO, can be convert to acetic acid chemically or biologically. Nowadays, acetic acid become a cost-effective nonfood-based carbon source for value-added biochemical production.
Ningyu Lai, Yuanchan Luo, Peng Fei, Peng Hu, Hui Wu   +4 more
doaj   +2 more sources

The Expression Modulation of the Key Enzyme Acc for Highly Efficient 3-Hydroxypropionic Acid Production [PDF]

Frontiers in Microbiology, 2022
3-Hydroxypropionic acid (3-HP) is a promising high value-added chemical. Acetyl-CoA carboxylase (Acc) is a vital rate-limiting step in 3-HP biosynthesis through the malonyl-CoA pathway.
Sumeng Wang, Xin Jin, Wei Jiang, Qian Wang, Qingsheng Qi, Quanfeng Liang   +5 more
doaj   +2 more sources

Development of an ethanol-based microbial platform for 3-hydroxypropionic acid production using engineered Pseudomonas putida KT2440. [PDF]

J Biol Eng
Ethanol is an attractive C2 feedstock for microbial biomanufacturing because it is directly oxidized to acetyl-CoA with favorable redox balance. 3-Hydroxypropionic acid (3-HP), a versatile platform chemical, can be synthesized via the malonyl-CoA and β ...
Sarwar A, Nguyen LT, Lee EY.
europepmc   +2 more sources

Directed Evolution of Branched-Chain α-Keto Acid Decarboxylase for 3-Hydroxypropionic Acid Production in <i>Escherichia coli</i> via Oxaloacetate. [PDF]

ACS Synth Biol
3-Hydroxypropionic acid (3-HP) serves as a crucial platform chemical with diverse applications across various industries. In this study, the oxaloacetate pathway was utilized for 3-HP production.
Wang C, Olsthoorn RCL, de Groot HJM.
europepmc   +2 more sources

Engineering <i>Kluyveromyces marxianus</i> for 3-hydroxypropionic acid production at elevated temperature from Jerusalem artichoke tubers and crude glycerol. [PDF]

Synth Syst Biotechnol
This study engineered the thermotolerant yeast Kluyveromyces marxianus to produce 3-hydroxypropionic acid (3-HP), a key precursor for biodegradable plastics, via the malonyl-CoA pathway using non-food feedstocks.
Li J, Hu Z, Li Y, Zha H, Xie Y, Zhao M, Ren L, Zhang B.   +7 more
europepmc   +2 more sources

High throughput ¹³C-metabolic flux analysis of 3-hydroxypropionic acid producing Pichia pastoris reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux. [PDF]

Microb Cell Fact, 2023
Background Production of 3-hydroxypropionic acid (3-HP) through the malonyl-CoA pathway has yielded promising results in Pichia pastoris ( Komagataella phaffii ), demonstrating the potential of this cell factory to produce this platform chemical and ...
Fina A, Millard P, Albiol J, Ferrer P, Heux S.   +4 more
europepmc   +2 more sources

Integration of Proteomics and Metabolomics Into the Design, Build, Test, Learn Cycle to Improve 3-Hydroxypropionic Acid Production in Aspergillus pseudoterreus [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
Biological engineering of microorganisms to produce value-added chemicals is a promising route to sustainable manufacturing. However, overproduction of metabolic intermediates at high titer, rate, and yield from inexpensive substrates is challenging in ...
Kyle R. Pomraning, Ziyu Dai, Nathalie Munoz, Young-Mo Kim, Yuqian Gao, Shuang Deng, Joonhoon Kim, Joonhoon Kim, Beth A. Hofstad, Marie S. Swita, Teresa Lemmon, James R. Collett, Ellen A. Panisko, Bobbie-Jo M. Webb-Robertson, Jeremy D. Zucker, Carrie D. Nicora, Henrique De Paoli, Scott E. Baker, Kristin E. Burnum-Johnson, Nathan J. Hillson, Jon K. Magnuson, Jon K. Magnuson   +21 more
doaj   +2 more sources

Systematic engineering of Escherichia coli for biosynthesis of 3-hydroxypropionic acid from glucose and malonate [PDF]

BMC Biotechnology
Background 3-Hydroxypropionic acid (3-HP) is a promising C3 platform chemical with wide industrial applications. However, its microbial production remains limited by insufficient intracellular malonyl-CoA availability and metabolic imbalance.
Yingying Wang, Meihui Cao, Mei Hu, Hengrui Xu, Yafei Du, Changxing Sun, Lingfei Kong, Yu Luo, Xiaoyu Liu, Jianming Yang, Bo Liang   +10 more
doaj   +2 more sources

Biological Production of 3-Hydroxypropionic Acid: An Update on the Current Status

Fermentation, 2018
The production of high added-value chemicals from renewable resources is a necessity in our attempts to switch to a more sustainable society. 3-Hydroxypropionic acid (3HP) is a promising molecule that can be used for the production of an important array ...
Leonidas Matsakas, Kateřina Hrůzová, Ulrika Rova, Paul Christakopoulos   +3 more
doaj   +3 more sources

3-Hydroxypropionic Acid Enhances Hair Growth-Related Signaling in Human Follicle Dermal Papilla Cells via Activation of the Wnt/β-Catenin Pathway. [PDF]

Int J Mol Sci
Hair loss is a common condition that affects a large number of people worldwide, impacting both men and women. Its development is closely linked to the function of hair follicle dermal papilla cells (HFDPCs), which play a pivotal role in maintaining hair
Jeon CY, Jo YH, Woo SA, Lee Y, Jung W, Shin DW.   +5 more
europepmc   +2 more sources