Results 21 to 30 of about 263,492 (261)
Neurotoxicity of .BETA.-amyloid.
Folia Pharmacologica Japonica, 2000 Recent observations on the neurotoxicity of beta-amyloid have been reviewed and possible roles of racemization of beta-amyloid are discussed. beta 1-40, beta 25-35 and D-Ser26 beta 25-35 (all HCl salt forms), but not commercially available beta 1-40 (TFA salt form), take the beta-structure within few hours in PBS, form fibrils, exert toxic effects on ...
KANEKO, Isao +2 more
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Synapses, synaptic activity and intraneuronal Aβ in Alzheimer's disease
Frontiers in Aging Neuroscience, 2010 β-amyloid peptide accumulation plays a central role in the pathogenesis of Alzheimer’s disease. Aberrant β-amyloid buildup in the brain has been shown to be present both in the extracellular space and within neurons.
Davide Tampellini
doaj +1 more source
Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
Molecular Neurodegeneration, 2009 Background The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain including monomers, oligomers, and ...
O'Connor Peter B +4 more
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Amyloid oligomer conformation in a group of natively folded proteins. [PDF]
PLoS ONE, 2008 Recent in vitro and in vivo studies suggest that destabilized proteins with defective folding induce aggregation and toxicity in protein-misfolding diseases.
Yuji Yoshiike +5 more
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DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? [PDF]
PLoS ONE, 2011 Numerous reports have documented the beneficial effects of dietary docosahexaenoic acid (DHA) on beta-amyloid production and Alzheimer's disease (AD).
Zareen Amtul +5 more
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Molecules that Target beta‐Amyloid
ChemMedChem, 2007 AbstractThe devastating effects of Alzheimer’s and related amyloidogenic diseases have inspired the synthesis and evaluation of numerous ligands to understand the molecular mechanism of the aggregation of the beta‐amyloid peptide. Our review focuses on the current knowledge in this field with respect to molecules that have been demonstrated to interact
Stains, Cliff I. +2 more
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Malang Neurology Journal, 2017 Background. Alzheimer's disease is a progressive neurologic disease of the brain that triggers irreversible neuronal cell loss, which can interfere with social and occupational functioning.
M. Rasjad Indra +2 more
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Plasma pyroglutamate‐modified amyloid beta differentiates amyloid pathology
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Introduction Pyroglutamate‐modified amyloid β (AβpE3) could be a biomarker for Aβ plaque pathology in the brain. An ultra‐high‐sensitive assay is needed for detecting AβpE3‐40.
Pei‐Ning Wang +6 more
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Frontiers in Aging Neuroscience, 2020 Despite the extensive use of hormonal methods as either contraception or menopausal hormone therapy (HT), there is very little known about the potential effects of these compounds on the cellular processes of the brain.
Keyana N. Porter +6 more
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Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC
Advanced Science, 2020 The gut–brain axis has attracted increasing attention in recent years, fueled by accumulating symptomatic, physiological, and pathological findings. In this study, the aggregation and toxicity of amyloid beta (Aβ), the pathogenic peptide associated with ...
Ibrahim Javed +10 more
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