Results 21 to 30 of about 1,107,155 (284)
Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH. [PDF]
, 2002 BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Abeta, in the brain. Abeta arises from cleavage of the Amyloid Precursor protein by beta and gamma secretases, which present attractive candidates
Brian Austen +5 more
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Consequences of the interaction of amyloid beta with amyloid binding alcohol dehydrogenase and the receptor for advanced glycation end products [PDF]
, 2008 Amyloid beta (Aβ) has been postulated to be the principle initiator of the pathogenesis of Alzheimer’s disease (AD). Therefore, understanding the underlying mechanisms of Aβ induced neurotoxicity in the early stages of AD would be essential for finding ...
Ren, Yimin
core +2 more sources
Amyloid oligomer conformation in a group of natively folded proteins. [PDF]
PLoS ONE, 2008 Recent in vitro and in vivo studies suggest that destabilized proteins with defective folding induce aggregation and toxicity in protein-misfolding diseases.
Yuji Yoshiike +5 more
doaj +1 more source
DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? [PDF]
PLoS ONE, 2011 Numerous reports have documented the beneficial effects of dietary docosahexaenoic acid (DHA) on beta-amyloid production and Alzheimer's disease (AD).
Zareen Amtul +5 more
doaj +1 more source
Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC
Advanced Science, 2020 The gut–brain axis has attracted increasing attention in recent years, fueled by accumulating symptomatic, physiological, and pathological findings. In this study, the aggregation and toxicity of amyloid beta (Aβ), the pathogenic peptide associated with ...
Ibrahim Javed +10 more
doaj +1 more source
Beta-amyloid imaging in dementia [PDF]
Yeungnam University Journal of Medicine, 2018 Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular plaques, composed of amyloid-beta (Aβ), in the brain. Although the precise mechanism underlying the neurotoxicity of Aβ has not been established, Aβ accumulation is the primary event in a cascade of events that lead to neurofibrillary degeneration and dementia.
openaire +3 more sources
Malang Neurology Journal, 2017 Background. Alzheimer's disease is a progressive neurologic disease of the brain that triggers irreversible neuronal cell loss, which can interfere with social and occupational functioning.
M. Rasjad Indra +2 more
doaj +1 more source
Plasma pyroglutamate‐modified amyloid beta differentiates amyloid pathology
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Introduction Pyroglutamate‐modified amyloid β (AβpE3) could be a biomarker for Aβ plaque pathology in the brain. An ultra‐high‐sensitive assay is needed for detecting AβpE3‐40.
Pei‐Ning Wang +6 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2020 Despite the extensive use of hormonal methods as either contraception or menopausal hormone therapy (HT), there is very little known about the potential effects of these compounds on the cellular processes of the brain.
Keyana N. Porter +6 more
doaj +1 more source
Molecules that Target beta‐Amyloid
ChemMedChem, 2007 AbstractThe devastating effects of Alzheimer’s and related amyloidogenic diseases have inspired the synthesis and evaluation of numerous ligands to understand the molecular mechanism of the aggregation of the beta‐amyloid peptide. Our review focuses on the current knowledge in this field with respect to molecules that have been demonstrated to interact
Stains, Cliff I. +2 more
openaire +3 more sources