Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]
Neurodegenerative Diseases, 2009 Alzheimer-disease-associated β-amyloid (Aβ) is produced by sequential endoproteolysis of β-amyloid protein precursor (βAPP): the extracellular portion is shed by cleavage in the juxtamembrane region by β-amyloid-cleaving enzyme (BACE)/β-secretase, after which it is cleaved by presenilin (PS)/γ-secretase near the middle of the transmembrane domain. Thus,
Itoh, Naohiro +27 more
openaire +5 more sources
Hippocampal Beta-Amyloid Accumulation In Aluminium Chloride and D-Galactose-Induced Rats: Establishing a Nontransgenic Alzheimer’s Model [PDF]
Journal of Pharmacy and Bioallied SciencesBackground: Alzheimer’s disease (AD) is characterized by tau protein aggregation and beta-amyloid (Aβ) plaques leading to progressive cognitive decline.
Thirupathirao Vishnumukkala +6 more
doaj +2 more sources
Plasma Beta-Amyloid and Metabolic Biomarkers: Age- and Sex-Stratified Analyses Suggest Limited Population-Level Associations [PDF]
MedicinaBackground and Objectives: This study examined the relationships between plasma beta-amyloid levels and systemic inflammatory, thyroid, and lipid biomarkers using complementary analytical approaches in a cross-sectional cohort undergoing plasma OAβ and ...
Hyeokjun Yun +2 more
doaj +2 more sources
Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]
, 2011 Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory +2 more
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Structural Studies of Cystatin B Amyloid Fibre and Oligomer [PDF]
, 2013 Amyloid fibres are characteristic of over 25 degenerative human diseases including Alzheimer’s and Parkinson’s disease. Amyloid fibres are insoluble, highly stable, ordered cross-β sheet structures, which form as a result of conformational change and ...
Davis, Peter J.
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The copper-amyloid-beta-peptide complex of Alzheimer’s disease: affinity, structure, fibril formation and toxicity [PDF]
, 2010 PhDSenile plaques of Alzheimer’s disease (AD) patients are composed primarily of the amyloid-β-peptide peptide (Aβ), and within these plaques Cu2+ ions are found concentrated and directly bound to Aβ.
Sarell, Claire Jessica
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Regulation of the metabolism of the Alzheimer's amyloid precursor protein by contactin 5 and BIN1 [PDF]
, 2012 Alzheimer’s disease (AD) is a progressive form of dementia, which currently has no cure. The metabolism of the amyloid precursor protein (APP) is an important determinant in the development of AD.
Glennon, Elizabeth Bernadette Claire
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Mitochondrial β-amyloid in Alzheimer's disease [PDF]
, 2011 This research is supported by Alzheimer's Research UK, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and
Ainge, JA +20 more
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Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]
, 2006 Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
core +1 more source
Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
Molecular Neurodegeneration, 2009 Background The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain including monomers, oligomers, and ...
O'Connor Peter B +4 more
doaj +1 more source