Results 11 to 20 of about 896,426 (307)

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]

Neurodegenerative Diseases, 2009
Alzheimer-disease-associated β-amyloid (Aβ) is produced by sequential endoproteolysis of β-amyloid protein precursor (βAPP): the extracellular portion is shed by cleavage in the juxtamembrane region by β-amyloid-cleaving enzyme (BACE)/β-secretase, after which it is cleaved by presenilin (PS)/γ-secretase near the middle of the transmembrane domain. Thus,
Itoh, Naohiro, Okochi, Masayasu, Tagami, Shinji, Nishitomi, Kouhei, Nakayama, Taisuke, Yanagida, Kanta, Fukumori, Akio, Jiang, Jingwei, Mori, Kohji, Hosono, Motoko, Kikuchi, Jyunko, Nakano, Yuko, Takinami, Yoshihiko, Dohi, Keiji, Nishigaki, Atsuko, Takemoto, Hiroshi, Minagawa, Kazuyuki, Katoh, Takaaki, Willem, Michael, Haass, Christian, Morihara, Takashi, Tanaka, Toshihisa, Kudo, Takashi, Hasegawa, Hiroshi, Nishimura, Masaki, Sakaguchi, Gaku, Kato, Akira, Takeda, Masatoshi   +27 more
openaire   +5 more sources

Small-angle X-ray scattering characterization of a $$\beta $$ β -amyloid model in phantoms

BMC Research Notes, 2020
Objective We present a method to prepare an amyloid model at scalable quantities for phantom studies to evaluate small-angle x-ray scattering systems for amyloid detection. Two amyloid models were made from a plasma protein with and without heating. Both
Sophya Breedlove, Jasson Crentsil, Eshan Dahal, Aldo Badano   +3 more
doaj   +1 more source

Neurotoxicity of .BETA.-amyloid.

Folia Pharmacologica Japonica, 2000
Recent observations on the neurotoxicity of beta-amyloid have been reviewed and possible roles of racemization of beta-amyloid are discussed. beta 1-40, beta 25-35 and D-Ser26 beta 25-35 (all HCl salt forms), but not commercially available beta 1-40 (TFA salt form), take the beta-structure within few hours in PBS, form fibrils, exert toxic effects on ...
KANEKO, Isao, KUBO, Takekazu, MORIMOTO, Kiyoshi   +2 more
openaire   +3 more sources

Synapses, synaptic activity and intraneuronal Aβ in Alzheimer's disease

Frontiers in Aging Neuroscience, 2010
β-amyloid peptide accumulation plays a central role in the pathogenesis of Alzheimer’s disease. Aberrant β-amyloid buildup in the brain has been shown to be present both in the extracellular space and within neurons.
Davide Tampellini
doaj   +1 more source

Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]

, 2006
Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
core   +1 more source

Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide

Molecular Neurodegeneration, 2009
Background The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain including monomers, oligomers, and ...
O'Connor Peter B, Zhao Cheng, Yamin Rina, McKee Ann C, Abraham Carmela R   +4 more
doaj   +1 more source

β-Amyloid Monomers Are Neuroprotective [PDF]

The Journal of Neuroscience, 2009
The 42-aa-long β-amyloid protein—Aβ 1-42 —is thought to play a central role in the pathogenesis of Alzheimer's disease (AD) (Walsh and Selkoe, 2007). Data from AD brain (Shankar et al., 2008), transgenic APP (amyloid precursor protein)-overexpressing mice (Lesné et al., 2006), and neuronal ...
ML Giuffrida, F Caraci, B Pignataro, S Cataldo, P De Bona, V Bruno, G Molinaro, G Pappalardo, A Messina, A Palmigiano, D Garozzo, F Nicoletti, E Rizzarelli, A Copani   +13 more
openaire   +6 more sources

Amyloid oligomer conformation in a group of natively folded proteins. [PDF]

PLoS ONE, 2008
Recent in vitro and in vivo studies suggest that destabilized proteins with defective folding induce aggregation and toxicity in protein-misfolding diseases.
Yuji Yoshiike, Ryoichi Minai, Yo Matsuo, Yun-Ru Chen, Tetsuya Kimura, Akihiko Takashima   +5 more
doaj   +1 more source

Molecules that Target beta‐Amyloid

ChemMedChem, 2007
AbstractThe devastating effects of Alzheimer’s and related amyloidogenic diseases have inspired the synthesis and evaluation of numerous ligands to understand the molecular mechanism of the aggregation of the beta‐amyloid peptide. Our review focuses on the current knowledge in this field with respect to molecules that have been demonstrated to interact
Stains, Cliff I., Mondal, Kalyani, Ghosh, Indraneel   +2 more
openaire   +3 more sources

Beta-Amyloid Deposition and the Aging Brain [PDF]

Neuropsychology Review, 2009
A central issue in cognitive neuroscience of aging research is pinpointing precise neural mechanisms that determine cognitive outcome in late adulthood as well as identifying early markers of less successful cognitive aging. One promising biomarker is beta amyloid (Abeta) deposition.
Karen M, Rodrigue, Kristen M, Kennedy, Denise C, Park   +2 more
openaire   +2 more sources