Results 91 to 100 of about 1,125,892 (364)

Expression of E-cadherin, beta-catenin and Ki-67 antigen and their reciprocal relationships in mammary adenocarcinomas in bitches.

Folia Histochemica et Cytobiologica, 2007
In progression of tumours, resulting from, i.e., release of cells from the parental tumour and development of metastases, expression of cell adhesion molecules (CAM) plays a significant role.
Marcin Nowak, Janusz A Madej, Piotr Dziegiel   +2 more
doaj   +1 more source

Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner. [PDF]

PLoS Biology, 2010
In vertebrates, the conserved Wnt signalling cascade promotes the stabilization and nuclear accumulation of beta-catenin, which then associates with the lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) to activate target genes.
Dimple Notani, Kamalvishnu P Gottimukkala, Ranveer S Jayani, Amita S Limaye, Madhujit V Damle, Sameet Mehta, Prabhat Kumar Purbey, Jomon Joseph, Sanjeev Galande   +8 more
doaj   +1 more source

Pharmacological modulation of beta-catenin and its applications in cancer therapy

Journal of Cellular and Molecular Medicine, 2013
Beta‐catenin (β‐catenin) is a multifunction protein with a central role in physiological homeostasis. Its abnormal expression leads to various diseases including cancer.
R. Thakur, D. Mishra
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The potential involvement of E-cadherin and beta-catenins in meningioma. [PDF]

PLoS ONE, 2010
OBJECTIVE: To investigate the potential involvements of E-cadherin and beta-catenin in meningioma. METHODS: Immunohistochemistry staining was performed on samples from patients with meningioma.
Keiyu Zhou, Guangtao Wang, Yirong Wang, Hanghuang Jin, Shuxu Yang, Chibo Liu   +5 more
doaj   +1 more source

Anomalous vascularization in a Wnt medulloblastoma: A case report [PDF]

, 2016
BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature.
Cacchione, Antonella, Carai, Andrea, Colafati, Giovanna Stefania, Dell'Anna, Vito Andrea, Di Giannatale, Angela, Diomedi Camassei, Francesca, Ferretti, Elisabetta, Locatelli, Franco, Marrazzo, Antonio, Mastronuzzi, Angela, Miele, Evelina, Po, Agnese   +11 more
core   +2 more sources

Associations of beta-catenin alterations and MSI screening status with expression of key cell cycle regulating proteins and survival from colorectal cancer

Diagnostic Pathology, 2013
BackgroundDespite their pivotal roles in colorectal carcinogenesis, the interrelationship and prognostic significance of beta-catenin alterations and microsatellite instability (MSI) in colorectal cancer (CRC) needs to be further clarified. In this paper,
S. Wangefjord, J. Brändstedt, K. E. Lindquist, B. Nodin, K. Jirström, J. Eberhard   +5 more
semanticscholar   +1 more source

MENA Is a Transcriptional Target of the Wnt/Beta-Catenin Pathway

PLoS ONE, 2012
Wnt/β-catenin signalling pathway plays important roles in embryonic development and carcinogenesis. Overactivation of the pathway is one of the most common driving forces in major cancers such as colorectal and breast cancers. The downstream effectors of the pathway and its regulation of carcinogenesis and metastasis are still not very well understood.
Ayaz Najafov, Tuncay Şeker, İpek Even, Gerta Hoxhaj, Osman Selvi, Duygu Esen Özel, Ahmet Koman, Necla Birgül-İyison   +7 more
openaire   +6 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source