Results 121 to 130 of about 116,860 (335)
Drug Design, Development and Therapy, 2019 Xianhua Huang*, Zhixi Chen*, Weimei Shi, Rui Zhang, Linfu Li, Hai Liu, Longhuo WuCollege of Pharmacy, Gannan Medical University, Ganzhou, People’s Republic of China*These authors contributed equally to this work Background: miR-29a, a downstream ...
Huang X +6 more
doaj
The evolutionary history of the catenin gene family during metazoan evolution
BMC Evolutionary Biology, 2011 Background Catenin is a gene family composed of three subfamilies; p120, beta and alpha. Beta and p120 are homologous subfamilies based on sequence and structural comparisons, and are members of the armadillo repeat protein superfamily.
Reynolds Albert B +2 more
doaj +1 more source
V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift. [PDF]
, 1995 Hiroshi Takeda +6 more
openalex +1 more source
Advanced Science, EarlyView.This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang +13 more
wiley +1 more source
Advanced Science, EarlyView.LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang +5 more
wiley +1 more source
Expressions of Frat and beta-catenin in lung cancer and their clinicopathological correlations
Chinese Journal of Lung Cancer, 2008 Background and objective Frat proteins are positive regulator of Wnt-signal transduction.By binding to GSK3,Frat prevents the phosphorylation and concomitant degradation of beta-catenin and allows the activation of downstream targetgenes by beta-catenin ...
Ning GUO +3 more
doaj
Retinoids increase cell-cell adhesion strength, beta-catenin protein stability, and localization to the cell membrane in a breast cancer cell line: a role for serine kinase activity [PDF]
, 1996 Stephen W. Byers
openalex +1 more source
Advanced Science, EarlyView.A multifunctional, edible, and hydrogel‐transformable probiotic powder is developed based on the “bacteria‐mediated bacterial eradication” strategy. By leveraging the targeted binding capability of L. reuteri to H. pylori, this approach achieves an integrated therapeutic effect, including bactericidality, anti‐inflammation, gastric mucosal repair, and ...
Yongkang Lai +9 more
wiley +1 more source
Excess beta -catenin promotes accumulation of transcriptionally active p53 [PDF]
, 1999 Alexander Damalas
openalex +1 more source
Advanced Science, EarlyView.CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan +9 more
wiley +1 more source