Results 171 to 180 of about 1,125,892 (364)

Overexpression of Aquaporin 1 in Synovium Aggravates Rat Collagen-Induced Arthritis Through Regulating β-Catenin Signaling: An in vivo and in vitro Study

open access: yesJournal of Inflammation Research, 2020
Yu-rong Mu1,2 ,* Meng-yuan Zhou1,2 ,* Li Cai,3 Ming-ming Liu,1,2 Rong Li1,2 1School of Pharmacy, Anhui Medical University, Hefei, Anhui Province, People’s Republic of China; 2Inflammation and Immune Mediated Diseases Laboratory of Anhui Province ...
Mu Y, Zhou M, Cai L, Liu M, Li R
doaj  

Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos

open access: yesAdvanced Science, EarlyView.
This study performs a comprehensive single‐cell transcriptome analysis of sheep embryos from embryonic (E) day 1 to E14 to elucidate the mechanism of early lineage specification and the pluripotency changes (naïve, formative, and primed) of epiblast.
Jinying Zhang   +28 more
wiley   +1 more source

Sox17 Promotes Oligodendrocyte Regeneration by Dual Modulation of Hedgehog and Wnt Signaling

open access: yesiScience, 2020
Summary: Signaling pathways that promote oligodendrocyte development improve oligodendrocyte regeneration and myelin recovery from demyelinating pathologies.
Xiaotian Ming   +3 more
doaj  

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

open access: yesAdvanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu   +6 more
wiley   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen   +12 more
wiley   +1 more source

Wnt/beta-Catenin Signaling in Alzheimer's Disease.

open access: yes, 2014
CR2
De Ferrari, G. V.   +5 more
openaire   +4 more sources

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