Results 171 to 180 of about 116,860 (335)

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

open access: yesAdvanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo   +10 more
wiley   +1 more source

Production of recombinant human beta-catenin protein in Ecoli and screening for anti-beta-catenin

open access: yes, 2000
Ankara : Department of Molecular Biology and Genetics and Institute of Engineering and Science of Bilkent Univ., 2000. Thesis (Master's) -- Bilkent University, 2000. Includes bibliographical references leaves 77-86 The p-catenin gene is a component of wnt pathway involved in developmental pattern formation. The protein product is involved in both cell-
openaire   +1 more source

Osteopenic occult vertebral fracture is associated with poor oncological outcome in patients with hepatocellular carcinoma after hepatic resection

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Osteopenic occult vertebral fracture (OVF) was associated with poor long‐term outcomes in patients with HCC after hepatic resection. Osteopenic OVF had a poorer prognosis than that of patients with either osteopenia or OVF. Abstract Background Although osteopenia has been associated with poor outcomes in patients with hepatocellular carcinoma (HCC ...
Koichiro Haruki   +9 more
wiley   +1 more source

Expanding the SIAH1‐Associated Phenotypic Spectrum: Insights From Loss‐of‐Function Variants

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT SIAH1 encodes for a RING‐type E3 ubiquitin ligase involved in protein ubiquitination. More specifically, it positively regulates Wnt signaling through promoting the accumulation of β‐catenin and mediates ubiquitination and degradation of Akt3 in neural development.
Liza Douiev   +14 more
wiley   +1 more source

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