Results 111 to 120 of about 149 (147)

Fibroblasts and hiPS‐Derived Astrocytes From CoPAN Patients Showed Different Levels of Iron Overload Correlated With Senescent Phenotype

Glia, Volume 73, Issue 7, Page 1467-1482, July 2025.
Main Points CoPAN affects CoA biosynthesis and leads to iron dyshomeostasis. CoPAN d‐astrocytes show ferroptosis, iron accumulation, senescence, lipid peroxidation, mitochondrial damage and tubulin acetylation loss. Astrocytes recapitulate CoPAN disease.
Anna Cozzi, Paolo Santambrogio, Andrea Stefano Moro, Alessio Pelagatti, Alicia Rubio, Chiara Balestrucci, Ivano Di Meo, Valeria Tiranti, Sonia Levi   +8 more
wiley   +1 more source

Bioinspired Cationic Antimicrobial Polymers

Angewandte Chemie International Edition, Volume 64, Issue 24, June 10, 2025.
A review about membrane active cationic polymers with antimicrobial properties. A focus is laid on polymeric architecture, stimuli‐responsive antimicrobial polymers, as well as synergistic effects of polymers, and other compounds. Abstract Antibiotics are an essential tool of modern medicine, which is critically endangered by the spread of ...
Heliya Javadi, Anne‐Catherine Lehnen, Matthias Hartlieb   +2 more
wiley   +1 more source

Stereoselective Total Synthesis of α‐Galacto‐Oligosaccharides Using Boron‐Mediated Aglycon Delivery and Evaluation of their Immune‐Enhancing Activities

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
This study reports the total synthesis of α‐galacto‐oligosaccharides (α‐GOSs) 1‐6 with different galactose chain lengths was achieved by the boron‐mediated aglycon delivery , and their immune‐enhancing activities in macrophage J774.1 cells. The results indicate that α‐GOS 2 exhibits the highest promotion of macrophage phagocytosis and increasing ...
Jikun Meng, Moeri Sagawa, Kazunobu Toshima, Daisuke Takahashi   +3 more
wiley   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin, Chuling Li, Zhaoyi Wu, Zhenquan Tang, Jingfang Xie, Guoquan Wei, Zhiwen Yang, Senlin Huang, Yijin Chen, Xinzhong Li, Yanmei Chen, Wangjun Liao, Yulin Liao, Guojun Chen, Hao Zheng, Jianping Bin   +15 more
wiley   +1 more source

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
wiley   +1 more source

Functional Analyses of SATB2 Variants Reveal Pathogenicity Mechanisms Linked With SATB2‐Associated Syndrome

American Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.
ABSTRACT SATB2‐associated syndrome (SAS) is characterized by intellectual disability, neurodevelopmental disorders, cleft palate, and dental abnormalities. SAS is caused by variants in the special AT‐rich sequence‐binding protein 2 (SATB2), which encodes a transcription factor containing two CUT domains and a homeobox (HOX) domain.
Nao Ukita, Takuya Ogawa, Mamiko Yamada, Chisen Takeuchi, Kenjiro Kosaki, Keiji Moriyama   +5 more
wiley   +1 more source

Incremental Modification in the Existing Approaches for Affinity Chromatographic Enrichment of Phosphoproteins Improves Their Profile in Liquid Chromatography‐Tandem Mass Spectrometry Analysis

Analytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Cell signalling is a vital process in cell physiology, which is driven by protein phosphorylation. Global phosphoproteome analysis by liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) has thus gained importance in cell signalling research.
Neha Agrawal, Rukmini Govekar
wiley   +1 more source

Fibroblasts‐specific p16INK4a exacerbates inflammageing‐mediated post‐infarction ventricular remodelling through interacting with STAT3 to regulate NLRP3 transcription

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
In ageing fibroblasts, p16INK4a concurrently enhanced STAT3 di‐methylation mediated by EZH2 and suppressed the assembly of Bmi‐1‐EZH2/BCL‐6 complexes at the NLRP3 promoter region. These dual regulatory actions synergistically upregulated STAT3‐dependent NLRP3 transcription, thereby exacerbating inflammageing‐driven ventricular remodelling following ...
Xin Gu, Yingqiang Du, Jin'ge Zhang, Jiyu Li, Haiyun Chen, Yujie Lin, Yue Wang, Chunli Zhang, Shiyu Lin, Nannan Hao, Chengyi Peng, Jiacheng Ge, Jin Liu, Yan Liang, Yongjie Zhang, Xiaoyan Wang, Fang Wang, Jianliang Jin   +17 more
wiley   +1 more source

Early genetic screening and cardiac intervention in patients with cardiomyopathies in a multidisciplinary clinic

ESC Heart Failure, Volume 12, Issue 3, Page 1942-1955, June 2025.
Abstract Aims Patients with cardiomyopathies are a heterogeneous group of patients who experience high morbidity and mortality. Early cardiac assessment and intervention with access to genetic counselling in a multidisciplinary Cardiomyopathy Clinic may improve outcomes and prevent progression to advanced heart failure.
Chandu Sadasivan, Luke R. Gagnon, Deepan Hazra, Kaiming Wang, Erik Youngson, Jissy Thomas, Anita Y.M. Chan, D. Ian Paterson, Finlay A. McAlister, Tara Dzwiniel, Wayne Tymchak, Susan Christian, Gavin Y. Oudit   +12 more
wiley   +1 more source