Results 101 to 110 of about 577 (171)
CellsIron is often accumulated in the liver during pathological conditions such as cirrhosis and cancer. Elevated expression of glucose transporters GLUT1 and GLUT3 is associated with reduced overall survival in patients with hepatocellular carcinoma. However,
Kleber S. Ribeiro +9 more
doaj +1 more source
Aminolysis of poly (.BETA.-hydroxybutyrate) and its copolymer.
Sen'i Gakkaishi, 1992 Poly (β-hydroxybutyrate) and its copolymer poly (β-hydroxybutyrate-co-β-hydroxyvalerate) P (HB-co-HV) were treated with methyl- and ethylamines. Melting peak temperatures, number-average molecular weights (Mn) and long spacings (L) of treated samples decreased as the concentration of amines or the treating time increased.
openaire +2 more sources
Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1057-1069, April 2026.Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka +12 more
wiley +1 more source
Techno‐economic analysis for hydroxy acids production from waste cellulose via alkaline digestion
Journal of Chemical Technology &Biotechnology, Volume 101, Issue 4, Page 904-914, April 2026.Abstract BACKGROUND Alkaline digestion offers a promising route for converting low‐grade cellulosic wastes into valuable hydroxy carboxylic acids (HAs). However, the feasibility of producing HAs at process scale, particularly the influence of reactor design on product yields, energy demand, and production costs, remains less explored.
Farangis Fallahmehneh +3 more
wiley +1 more source
Analyzing Nicotine Action Against Amyloid Toxicity by NMR‐Pharmacometabolomics: An Exploratory Study
NMR in Biomedicine, Volume 39, Issue 4, April 2026.Combined metabolomic analysis of the intracellular and extracellular portions of SH‐SY5Y cells revealed that, in the presence of Aβ 1–42, nicotine primarily influences pathways related to neurotransmission, energy metabolism, as well as the biosynthesis and degradation of membrane phospholipids.
Enza Napolitano +5 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Repeated intermittent fasting elevates hippocampal β‐hydroxybutyrate (BHB), remodels HDAC activity and histone acetylation, and drives a metabolic–epigenetic transition from transient chromatin priming after a single fast to a sustained cytoprotective program associated with reduced DNA damage and enhanced genome maintenance.
Hadar Parnas +5 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.1,3‐Butanediol is a ketone body precursor that is directly converted into the ketone bodies, β‐hydroxybutyrate (BHB), in the liver. When renal ketolysis, regulated by 3‐oxoacid CoA‐transferase 1 (OXCT1), is preserved, BHB supplementation exerts renoprotective effects.
Shoji Omachi +13 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Weekly moderate‐to‐vigorous activity (≈6 h) induced a marked increase in ACE promoter methylation in exercised knee‐extensor muscle. In combination with the ACE I/D genotype, ACE methylation contributed to ACE gene activity regulation in ways aligning with the slow‐twitch, aerobic muscle phenotype and its metabolic response to endurance exercise ...
Flück Martin +2 more
wiley +1 more source
Cancer, Volume 132, Issue 6, 15 March 2026.ABSTRACT Background A randomized phase II screening trial of gemcitabine, nab‐paclitaxel, and cisplatin with a medically supervised ketogenic diet (MSKD) versus usual diet (non‐MSKD) was conducted in patients with treatment‐naive metastatic pancreatic ductal adenocarcinoma (PDAC).
Gayle S. Jameson +21 more
wiley +1 more source