Results 111 to 120 of about 637,109 (288)

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Phi Beta Kappa Minutes, December 5, 1776-January 6,1781 [PDF]

Ledger of the Phi Beta Kappa minutes of meetings from December 5, 1776-January 6, 1781. These are the earliest meetings of Phi Beta Kappa.
Phi Beta Kappa
core  

Nitrooxylation in Organic Synthesis: From Classical Nitrate Ester Formation to Modern Catalytic Strategies

Chemistry – A European Journal, EarlyView.
Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley   +1 more source

Relay Approach: A Convergent Synthesis of Key Fragments en route to (+)‐Neosorangicin A

Chemistry – A European Journal, EarlyView.
A selective synthesis of three key fragments of the antibiotically active (+)‐neosorangicin A is reported, providing a foundation for its convergent total synthesis and proof of strategy via a relay approach. ABSTRACT Herein, we report the synthesis of the three key fragments of the macrolide antibiotic (+)‐neosorangicin A, a compound exhibiting potent
Marvin Wenninger, Maxim Munt, Le Chang, Rositsa Stoykova, Roberto Ojcius, Oliver Spieß, Dieter Schinzer   +6 more
wiley   +1 more source

Phi Beta Kappa: The Key Reporter Winter 2012-2013 [PDF]

, 2012
Announcement of the Beta of Nebraska chapter installation at Creighton University, p.
Phi Beta Kappa Society
core  

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Systematic Review of Beta-Lactam vs. Beta-Lactam plus Aminoglycoside Combination Therapy in Neutropenic Cancer Patients [PDF]

We performed a systematic review of studies that compared beta-lactams vs. beta-lactams plus aminoglycosides for the treatment of febrile neutropenia in cancer patients. Method: We searched CENTRAL, MEDLINE, and Embase for studies published up to October
Tomoaki Nakamura, Fujimi Kawai, Kazuhiro Ishikawa, Erika Ota, Nobuyoshi Mori   +4 more
core   +1 more source

Beta-Lactam Resistance

Revista de Gestão Social e Ambiental
Objective: Investigate beta-lactam resistance in order to identify the associated factors, the main beta-lactam resistant microorganisms and their complications.   Theoretical Framework: Beta-lactam resistance is a worldwide health problem, consisting of the inability to respond to the action of antibiotics.
Kerly Monserrath Pinos Larrea, Jacinto Eugenio Pérez Ramírez, Marco Vinicio Urgilés Rivas, Gustavo Adolfo Espinoza Palomeque, Juan Sebastián Urgilés Beltrán, Félix Miguel Sacoto Maldonado   +5 more
openaire   +1 more source

N‐Sulfonyl Azalevoglucosan: A Versatile Platform for the Synthesis of Polysubstituted Piperidines

Chemistry – A European Journal, EarlyView.
Gain by strain: The synthesis of a levoglucosan analog, in which the pyranose oxygen has been replaced by a nitrogen, allows navigation on the piperidine ring to iteratively install functional groups at C1, C2, C3, C4, and C6 positions using simple experimental protocols with minimal protecting group manipulation.
Dylan Yorga, Jérôme Marrot, Ana Poveda, Nicolas Auberger, Jesús Jiménez‐Barbero, Jérôme Désiré, Yves Blériot   +6 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source