Results 111 to 120 of about 89,494 (296)

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer   +6 more
wiley   +1 more source

SPR biosensor analysis of beta-lactam antibiotics in milk [PDF]

open access: yes, 2003
The aim of this study was to investigate the applicability of an SPR biosensor in combination with a beta-lactam receptor protein for generic detection of beta-lactam antibiotics in milk.
Gustavsson, Eva
core  

Evaluation of β-lactam monotherapy and conventional anti-staphylococcal combination therapy for polymicrobial MSSA infections

open access: yesJournal of Infection in Developing Countries
Introduction: Staphylococcus aureus (SA) remains a major pathogen in both community-acquired and healthcare-associated infections, necessitating effective treatment strategies. Management of infections involving methicillin-susceptible S.
Gulnihal Akbulut   +3 more
doaj   +1 more source

1,2‐Diazetidines − Structure, Synthesis, and Functionalization

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
1,2‐Diazetidines are saturated four‐membered heterocycles featuring two adjacent nitrogen atoms. Despite recent advances in their synthesis and promising potential in medicinal chemistry, the chemistry of these cyclic hydrazines remains underexplored.
Stefan Roesner
wiley   +1 more source

Lithium Diisopropylamide‐Mediated Ring‐Opening of Tetrahydrofuran in the Synthesis of Polyhydroxylated Indolizidines

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
Chiral tri‐ and pentahydroxy spirocyclopentane‐indolizidines were synthesized using lithium diisopropylamide “LDA” promoted diallylation and tetrahydrofuran “THF” ring‐opening in a one‐pot procedure as a key step. The sequence leading to the targeted hydroxy‐spiroindolizidines was achieved by cis‐dihydroxylation followed by reduction of the enamine and
Paula Fraňová   +6 more
wiley   +1 more source

Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein.

open access: yesPLoS Pathogens, 2009
It has long been recognized that the modification of penicillin-binding proteins (PBPs) to reduce their affinity for beta-lactams is an important mechanism (target modification) by which Gram-positive cocci acquire antibiotic resistance.
Bartolomé Moya   +6 more
doaj   +1 more source

Validated RP‐HPLC–UV Method for the Quantitative Analysis and Stability Evaluation of Amoxicillin in Paediatric Gummy Tablets

open access: yesELECTROPHORESIS, EarlyView.
A validated RP‐HPLC–UV method was successfully applied for amoxicillin determination in gummy tablets. The method is useful for an accurate amoxicillin content determination in paediatric gummies and was applied to study the stability profile of the drug, evaluated over 6 months under storage conditions.
Samuele Bonafè   +7 more
wiley   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera   +4 more
wiley   +1 more source

Recent Progress on Enzyme Immobilization: Materials, Strategies, and Applications

open access: yesFood Bioengineering, EarlyView.
Enzyme immobilization technology has undergone substantial evolution driven by advances in materials science. This review systematically examines the recent advances in enzyme immobilization since 2024, with a focused analysis of five major categories of enzyme carriers including covalent organic framework, metal‐organic frameworks, polymers, carbon ...
Shuran Wang   +7 more
wiley   +1 more source

Ontological representation of CDC Active Bacterial Core Surveillance Case Reports [PDF]

open access: yes, 2014
The Center for Disease Control and Prevention’s Active Bacterial Core Surveillance (CDC ABCs) Program is a collaborative effort betweeen the CDC, state health departments, laboratories, and universities to track invasive bacterial pathogens of particular
Cowell, Lindsay G.   +2 more
core  

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