Results 101 to 110 of about 89,494 (296)
Chemistry – A European Journal, EarlyView.Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis +2 more
wiley +1 more source
Impact of rapid mecA polymerase chain reaction rapid diagnostic testing for Staphylococcus aureus in a pediatric setting [PDF]
, 2018 Rapid molecular technology can detect the mecA resistance gene in Staphylococcus aureus (SA), predicting methicillin susceptibility in under one hour. In combination with antimicrobial stewardship program interventions in adults with SA bacteremia, rapid
Drwiega, Emily
core +1 more source
Metronidazole resistance: a hidden epidemic? [PDF]
, 2018 This is a personal reflection from working as a clinical microbiologist and becoming increasingly concerned over gaps in our knowledge of metronidazole resistance and its impact on clinical ...
Smith, Andrew
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The Visual Predictive Check and Real‐World Data
Clinical Pharmacology &Therapeutics, EarlyView.The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes +2 more
wiley +1 more source
Risk factors and outcomes for ineffective empiric treatment of sepsis caused by gram-negative pathogens: Stratification by onset of infection [PDF]
, 2017 Sepsis and septic shock remain serious consequences of infections, with reported mortality rates in excess of 40 percent. Timely antibiotic therapy in cases of sepsis and septic shock is recognized as an important determinant of outcome.
Hampton, Nicholas +2 more
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Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
Is There Emergence of β-Lactam Antibiotic-Resistant Streptococcus pyogenes in China?
Infection and Drug Resistance, 2020 Dingle Yu,1,2,* Yuejie Zheng,2,* Yonghong Yang1,2 1Laboratory of Microbiology and Immunology, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of China; 2Department of Respiratory, Shenzhen ...
Yu D, Zheng Y, Yang Y
doaj
Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria
Frontiers in Microbiology, 2013 Production of beta-lactamases, the enzymes that degrade beta-lactam antibiotics, is the most widespread and threatening mechanism of antibiotic resistance.
Ximin eZeng, Jun eLin
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Antimicrobial activity of an acetic and boric acid solution against Staphylococcus pseudintermedius [PDF]
, 2009 Incubation of 101 colony forming units/ml of Staphylococcus pseudintermedius in an undiluted, a 1:2 and a 1:4 diluted aqueous 2% acetic acid and 2% boric acid solution resulted in inactivation of the bacteria within 30, 60 and 120 minutes, respectively ...
Baele, Margo +4 more
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Antibacterial Activity of Heteropolytungstates Against Proteus mirabilis
European Journal of Inorganic Chemistry, EarlyView.We investigated the in vitro antibacterial activity of several heteropolytungstates against P. mirabilis, a drug‐resistant pathogen. All tested polyanions inhibited bacterial growth, with the Preyssler–Pope–Jeannin polyanion P5W30 exhibiting the highest activity (MIC = 0.78 mg/mL).
Nour El Ghouch +5 more
wiley +1 more source