Results 81 to 90 of about 637,109 (288)

A broad-spectrum beta-lactam-sparing stewardship program in a middle-income country public hospital: antibiotic use and expenditure outcomes and antimicrobial susceptibility profiles

Brazilian Journal of Infectious Diseases, 2020
Background: Antimicrobial stewardship programs are an efficient way to reduce inappropriate use of antimicrobials and costs; however, supporting data are scarce in middle-income countries.
Tiago Zequinao, Juliano Gasparetto, Dayana dos Santos Oliveira, Gabriel Takahara Silva, João Paulo Telles, Felipe Francisco Tuon   +5 more
doaj   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa

mBio
Pseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) released from the peptidoglycan (PG) cell wall upon beta-lactam treatment. AmpC can
Joël Gyger, Gabriel Torrens, Felipe Cava, Thomas G. Bernhardt, Coralie Fumeaux   +4 more
doaj   +1 more source

Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives

مجلة بغداد للعلوم, 2015
New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j).
Baghdad Science Journal
doaj   +1 more source

Association Between Clostridium difficile Infection and Beta-lactam Allergy [PDF]

, 2020
Introduction: There have been previous studies which suggest that there may be a relationship between allergy to beta-lactam antibiotics and development of clostridium difficile infection.
Tirumanisetty, Pratyusha, Kamal, Sheen, Syed, Tausif, Devgun, Surinder, Kouides, Ruth, Ari, Chodos   +5 more
core   +1 more source

Beta-lactams

, 2019
Beta-lactam antibiotics are the most popular antibacterial agents used for treating bacterial infections, due to their great activity, broad spectrum, and safety profile. All of them share the beta-lactam ring and because of the particular chemical structure, they are classified into five groups: Penicillins (natural and semisynthetic), cephalosporins (
Balsalobre, Luz, Blanco, Ana, Alarcón Cavero, Teresa   +2 more
openaire   +1 more source

Review of Clinical Outcomes in Patients Treated with Beta-lactam vs Non-beta-lactam Therapy for AmpC Producing Bacterial Bloodstream Infections [PDF]

, 2020
Background AmpC beta-lactamase producing organisms are traditionally treated with carbapenem or fluoroquinolone antibiotics. Recent studies, however, describe similar clinical outcomes in patients that receive cefepime or piperacillin/tazobactam.
Baumeister, Tyler, Staicu, Mary L, Laguio-Vila, Maryrose R   +2 more
core   +1 more source

Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated intra-abdominal infections [PDF]

, 2016
Jose A Hidalgo,1,2 Celeste M Vinluan,1–3 Nishaal Antony3 1UTEP/UT Austin Cooperative Pharmacy Program, College of Health Sciences, University of Texas at El Paso, El Paso, 2Department of Pharmacy, College of Pharmacy, The University of Texas at ...
Hidalgo JA, Vinluan CM, Antony N
core  

Combatting Pseudomonas aeruginosa with β-Lactam Antibiotics: A Revived Weapon? [PDF]

Pseudomonas aeruginosa is a significant threat to public health as an aggressive, opportunistic pathogen. The use of β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and carbapenems remains a front-line treatment against P ...
Dylan W. Zhao, Christopher T. Lohans
core   +1 more source

Target Fidelity and Failure: Structure–Activity Relationship of High-Molecular-Mass Penicillin-Binding Proteins (HMM-PBPs) in Refractory Granulicatella adiacens Endocarditis

Antibiotics
Background/Objectives: Granulicatella adiacens infective endocarditis is conventionally managed with penicillin, ampicillin, or ceftriaxone in combination with gentamicin, although double beta-lactam regiments have been proposed a safer alternative to ...
Paola Conti, Alberto Pagotto, Sebastiano A. Fortuna, Alessandra Giardina, Grete F. Privitera, Ester Rosa, Assunta Sartor, Carlo Tascini, Floriana Campanile   +8 more
doaj   +1 more source