Results 81 to 90 of about 824,973 (281)

Procalcitonin predicts response to beta-lactam treatment in hospitalized children with community-acquired pneumonia.

PLoS ONE, 2012
BackgroundAntibiotic treatment of community-acquired pneumonia (CAP) in children remains mostly empirical because clinical and paraclinical findings poorly discriminate the principal causes of CAP. Fast response to beta-lactam treatment can be considered
Jérémie F Cohen, Alexander Leis, Thibault Lecarpentier, Josette Raymond, Dominique Gendrel, Martin Chalumeau   +5 more
doaj   +1 more source

Functionalization of N-[(Silyl)methyl]-beta-lactam Carbanions with Carbon Electrophiles

, 2006
Latent acidity of alpha-alkyl-alpha-amino-N-[(silyl)methyl]-beta-lactams enabled a concise entry to lithium nonenolate N-methyl-azetidinone carbanions lithiated alpha' to the beta-lactam nitrogen, owing to the stabilizing "alpha-effect" of one or two ...
Palomo, Claudio, Fratila, Raluca M., Cuerdo, Lourdes, Linden, Anthony, Benito, Ana M., Aizpurua, Jesús M., Miranda, José Ignacio   +6 more
core   +1 more source

Surfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a. [PDF]

, 2014
Surfactant-mediated removal of proteins from biomembranes invariably results in partial or complete loss of function and disassembly of multi-protein complexes. We determined the capacity of styrene-co-maleic acid (SMA) co-polymer to remove components of
Taylor, Peter W, Paulin, S, Roper, David I, Garcia-Lara, J, Roper, DI, Taylor, PW, Galley, Nicola F., Paulin, Sarah, Rosado, H, Foster, SJ, Taylor, Peter W., Dafforn, TR, Dafforn, Tim, Dafforn, Timothy R, Galley, Nicola F, Jamshad, Mohammed, Rosado, Helena, Foster, Simon J, Garcia-Lara, Jorge, Jamshad, M, Galley, NF, Foster, Simon J., Roper, David I.   +22 more
core   +1 more source

Target Fidelity and Failure: Structure–Activity Relationship of High-Molecular-Mass Penicillin-Binding Proteins (HMM-PBPs) in Refractory Granulicatella adiacens Endocarditis

Antibiotics
Background/Objectives: Granulicatella adiacens infective endocarditis is conventionally managed with penicillin, ampicillin, or ceftriaxone in combination with gentamicin, although double beta-lactam regiments have been proposed a safer alternative to ...
Paola Conti, Alberto Pagotto, Sebastiano A. Fortuna, Alessandra Giardina, Grete F. Privitera, Ester Rosa, Assunta Sartor, Carlo Tascini, Floriana Campanile   +8 more
doaj   +1 more source

Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria

Frontiers in Microbiology, 2013
Production of beta-lactamases, the enzymes that degrade beta-lactam antibiotics, is the most widespread and threatening mechanism of antibiotic resistance.
Ximin eZeng, Jun eLin
doaj   +1 more source

Is There Emergence of β-Lactam Antibiotic-Resistant Streptococcus pyogenes in China?

Infection and Drug Resistance, 2020
Dingle Yu,1,2,* Yuejie Zheng,2,* Yonghong Yang1,2 1Laboratory of Microbiology and Immunology, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of China; 2Department of Respiratory, Shenzhen ...
Yu D, Zheng Y, Yang Y
doaj  

Oxidant-Scavenging Activities of Beta-Lactam Agents

, 1998
peer reviewedThe relative antioxidant effect of ampicillin, ceftazidime, ceftriaxone, and cefuroxime on oxygen-reactive species was examined in vitro using stimulated human polymorphonuclear neutrophils.
Jadoul, L., Carreer, R., Mathy, Marianne, Deby, C., Deby-Dupont, G.   +4 more
core   +1 more source

Delabelling beta-lactam allergy

Frontiers in Pharmacology
Background: Hypersensitivity to beta-lactam (BL) antibiotics is one of the most frequent reported drug allergies. In our population, it is common to find labels of BL allergy in electronic medical records (EMRs) that have not been assessed. The objective
Gustavo-Jorge Molina-Molina, Diana Rocío Garnica Velandia, Diana Rocío Garnica Velandia, Blanca Andrés-López, Carolina Perales, Laura Marin-Asensio, Yanina Jurgens, Olga Esteso, Carolina Escobar, Xavier Vidal, Xavier Vidal, Lourdes Vendrell, Lourdes Vendrell, Lourdes Vendrell, Laura Gómez-Ganda, Dolores Rodríguez, Eva Montané, Eva Montané, Victoria Cardona, Victoria Cardona, Antònia Agustí, Antònia Agustí   +21 more
doaj   +1 more source

Evaluation of β-lactam monotherapy and conventional anti-staphylococcal combination therapy for polymicrobial MSSA infections

Journal of Infection in Developing Countries
Introduction: Staphylococcus aureus (SA) remains a major pathogen in both community-acquired and healthcare-associated infections, necessitating effective treatment strategies. Management of infections involving methicillin-susceptible S.
Gulnihal Akbulut, Kathy Tin, Julia Sapozhnikov, Abdullah Chahin   +3 more
doaj   +1 more source

Antibacterial activity of beta-lactam antibiotics in experimental meningitis due to Streptococcus pneumoniae

, 1984
In order to define the characteristics of the antibacterial activity of beta-lactam antibiotics in the treatment of bacterial meningitis, the relationship between cerebrospinal fluid (CSF) drug concentrations and the rate of bacterial killing was ...
M. G. Tauber, M. A. Sande, Doroshow, CA, M. G. Rusnak, Täuber, MG, Drake, TA, C. J. Hackbarth, T. A. Drake, Hackbarth, CJ, C. A. Doroshow, Rusnak, MG, Sande, MA   +11 more
core   +1 more source