Results 71 to 80 of about 824,973 (281)

A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa

mBio
Pseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) released from the peptidoglycan (PG) cell wall upon beta-lactam treatment. AmpC can
Joël Gyger, Gabriel Torrens, Felipe Cava, Thomas G. Bernhardt, Coralie Fumeaux   +4 more
doaj   +1 more source

A broad-spectrum beta-lactam-sparing stewardship program in a middle-income country public hospital: antibiotic use and expenditure outcomes and antimicrobial susceptibility profiles

Brazilian Journal of Infectious Diseases, 2020
Background: Antimicrobial stewardship programs are an efficient way to reduce inappropriate use of antimicrobials and costs; however, supporting data are scarce in middle-income countries.
Tiago Zequinao, Juliano Gasparetto, Dayana dos Santos Oliveira, Gabriel Takahara Silva, João Paulo Telles, Felipe Francisco Tuon   +5 more
doaj   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives

مجلة بغداد للعلوم, 2015
New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j).
Baghdad Science Journal
doaj   +1 more source

Disruption of undecaprenyl phosphate recycling suppresses ampC beta-lactamase induction in Pseudomonas aeruginosa.

PLoS Pathogens
Beta-lactam antibiotics are widely used to treat bacterial infections, but their efficacy is compromised by resistance mechanisms such as the production of beta-lactamases.
Karina Klycheva, Joël Gyger, Mélissa Frund, Gabriel Torrens, Felipe Cava, Coralie Fumeaux   +5 more
doaj   +1 more source

Beta-lactams

, 2019
Beta-lactam antibiotics are the most popular antibacterial agents used for treating bacterial infections, due to their great activity, broad spectrum, and safety profile. All of them share the beta-lactam ring and because of the particular chemical structure, they are classified into five groups: Penicillins (natural and semisynthetic), cephalosporins (
Balsalobre, Luz, Blanco, Ana, Alarcón Cavero, Teresa   +2 more
openaire   +1 more source

Beta-lactam resistance genes detected in the K. pneumoniae isolates from wastewater and the corresponding clinical settings.

, 2020
Beta-lactam resistance genes detected in the K. pneumoniae isolates from wastewater and the corresponding clinical settings.
Ilda Czobor Barbu (8378826), Marius Surleac (8378823), Adrian Streinu-Cercel (5859971), Luminita Marutescu (8378835), Dan Otelea (374091), Simona Paraschiv (4500901), Oana Sandulescu (8378859), Marcela Popa (5925074), Ionela Sarbu (8378838), Manuela Arbune (8378850), Irina Gheorghe (8378832), Laura Ioana Popa (8378829), Alina Viorica Iancu (8378847), Mariana Carmen Chifiriuc (5925071), Daniela Talapan (8378841), Serban Nicolescu (8378856), Mihai Nita (8378844), Alina Manole (8378853)   +17 more
core   +1 more source

ftsI mutations versus beta-lactamase (blaTEM) production in beta-lactam resistance of Haemophilus influenzae: results from an university hospital in Istanbul

Journal of Global Antimicrobial Resistance
AIM: To determine in vitro susceptibilities of H. influenzae strains and to reveal the beta-lactam resistance mechanisms involved in those resistant to beta-lactams in our center. METHODS: Antibiotic susceptibilities of 122 H. influenzae isolated in 2022
Meltem Sarı Küçükerol, Burak Aksu, Ufuk Hasdemir   +2 more
doaj   +1 more source

Therapeutic drug monitoring of beta-lactam antibiotics in the ICU

, 2020
Introduction Individualizing antibiotic therapy is paramount to improve clinical outcomes while minimizing the risk of toxicity and antimicrobial therapy.
Boelens, Jerina, De Waele, Jan, Van Vooren, Sarah, Dhaese, Sofie   +3 more
core   +1 more source

Impact of Timing of Beta-Lactam Therapeutic Drug Monitoring and Therapy Adjustment in Critically Ill Patients

Antibiotics
Purpose: To assess the impact of beta-lactam therapeutic drug monitoring (TDM) timing and therapy adjustment on clinical cure and 30-day mortality. Methods: This was a prospective study of critically ill patients admitted to the University of Florida ...
Mohammad H. Alshaer, Nicole F. Maranchick, Kelly L. Maguigan, Bethany R. Shoulders, Mays J. Mousa, Melissa Murray, Jennifer Ashton, Kaitlin Alexander, Barbara A. Santevecchi, Kathryn DeSear, Veena Venugopalan, Kartikeya Cherabuddi, Charles A. Peloquin   +12 more
doaj   +1 more source