Results 71 to 80 of about 89,494 (296)
Nature Communications, 2023 There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast +13 more
doaj +1 more source
Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance. [PDF]
, 2018 Bifidobacterium species are important commensals capable of dominating the infant gut microbiome, in part by producing acids that suppress growth of other taxa.
Ahmad, SM +7 more
core +1 more source
Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]
, 2007 We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Gidijala, Loknath, +3 more
core +2 more sources
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew +8 more
wiley +1 more source
Identifying patients at risk for augmented renal clearance in the ICU : limitations and challenges [PDF]
, 2013 Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal.
Carlier, Mieke, De Waele, Jan
core +2 more sources
Brazilian Journal of Infectious Diseases, 2020 Background: Antimicrobial stewardship programs are an efficient way to reduce inappropriate use of antimicrobials and costs; however, supporting data are scarce in middle-income countries.
Tiago Zequinao +5 more
doaj +1 more source
Protein binding of β-lactam antibiotics in critically Ill patients: can we successfully predict unbound concentrations? [PDF]
, 2013 The use of therapeutic drug monitoring (TDM) to optimize beta-lactam dosing in critically ill patients is growing in popularity, although there are limited data describing the potential impact of altered protein binding on achievement of target ...
Adnan, Syamhanin +6 more
core +1 more source
mBioPseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) released from the peptidoglycan (PG) cell wall upon beta-lactam treatment. AmpC can
Joël Gyger +4 more
doaj +1 more source
Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives
مجلة بغداد للعلوم, 2015 New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j).
Baghdad Science Journal
doaj +1 more source
Escherichia coli EHEC Germany outbreak preliminary functional annotation using BG7 system [PDF]
, 2011 We have annotated the European outbreak E. coli EHEC genome sequenced by BGI (6-2-2011) and assembled with MIRA by Nick Loman (6-2-2011 ). Our system BG7, Bacterial Genome annotation of Era7 Bioinformatics, predicts ORFs and annotates them based on ...
Eduardo Pareja +4 more
core +2 more sources