Results 61 to 70 of about 637,109 (288)

Strain‐Release Pentafluorosulfanylation of Carbonyl‐Containing Disubstituted Bicyclobutanes: A Fortuitous Path to SF5‐Containing Oxa[2.1.1]bicyclohexanes

Angewandte Chemie, EarlyView.
A regio‐ and diastereoselective method for strain‐release pentafluorosulfanylation of carbonyl‐containing 1,3‐disubstituted [1.1.0]bicyclobutanes (BCBs) was developed that led to several fortuitous discoveries. For instance, the resultant SF5‐cyclobutanes (SF5‐CBs) exhibit close SF5⋯C═X contacts (X = C, N, O) and provide synthetic access to a new class
Alexander M. Stephens, Jake Anthony Olvera, Yannick Kraemer, Tyson Vu, Wang‐Yeuk Kong, Sudiksha Chaturvedi, Jeffrey M. Wang, Lauren M. Holder, Dean J. Tantillo, Cody Ross Pitts   +9 more
wiley   +2 more sources

Comparative in vitro activities of seven new beta-lactams, alone and in combination with beta-lactamase inhibitors, against clinical isolates resistant to third generation cephalosporins

Brazilian Journal of Infectious Diseases
We examined the drug susceptibility pattern of Gram-negative bacilli to seven new beta-lactams. A total of 277 non-duplicate gramnegative bacilli strains belonging to the Enterobacteriaceae family, Pseudomonas and Acinetobacter species, isolated from ...
Varsha Gupta, Priya Datta, Nalini Agnihotri, Jagdish Chander   +3 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Method for measuring beta-lactam antibiotics [PDF]

, 2011
The invention relates to a method for measuring beta-lactam antibiotics. The invention is particularly important to the monitoring and adjusting of a beta-lactam antibiotic dosage provided to a subject suffering from an infection treatable with beta ...
De Coninck, Joel, Goormaghtigh, Erik, Tulkens, Paul M., Marchand-Brynaert, Jacqueline   +3 more
core  

Iridium‐Catalyzed Ionic Hydrogenation of Multi‐Aza Heterocycles

Angewandte Chemie, EarlyView.
Saturated nitrogen‐containing heterocycles are ubiquitous in bioactive molecules and are thus attractive synthetic targets. A readily accessible cyclometalated iridium(III) complex reduces 14 different aromatic aza heterocycles to (partially)saturated multi aza‐heterocycles enlarging accessible chemical space while displaying high tolerance toward ...
Arthur Despois, Nicolai Cramer
wiley   +2 more sources

Immobilization of IMP-1 metallo-beta-lactamase on Fe3O4@SiO2 as nanobiocatalyst for degradation of beta-lactam antibiotics in wastewater

Water Science and Technology, 2022
Residues of antibiotics in water resources and wastewater have been significant environmental and public health problems. The current study developed a high-efficiency enzymatic nanobiocatalyst for the degradation of beta-lactam antibiotics.
Mohammad javad Shokoohizadeh, Ali Almasi, Farahnaz Karami, Seyyed Alireza Mousavi, Reza Khodarahmi   +4 more
doaj   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

β-Lactam resistance in Haemophilus parasuis is mediated by plasmid pB1000 bearing blaROB-1 [PDF]

, 2007
beta-Lactam resistance in Haemophilus parasuis is an emerging phenomenon that has not yet been characterized from a molecular perspective. Clinical high-level beta-lactam-resistant isolates from Spain bore a novel plasmid, pB1000, expressing a ...
Domínguez Rodríguez, Lucas José, San Millán, Álvaro, Escudero García-Calderón, José Antonio, Catalán, Ana, Gibert, Magdalena, González Zorn, Bruno, Moreno Romo, Miguel Ángel, Farelo, Fidel, Nieto, Silvia   +8 more
core   +1 more source

Photochemical Ring Opening of Cyclopropyl Silyl Ethers Enables β–β Coupling, Radical‐Polar Crossover and Annulation

Angewandte Chemie, EarlyView.
A photochemical platform enables β–β coupling of cyclopropyl silyl ethers with electron‐deficient alkenes. The resulting adducts serve as entry points into annulative and radical–polar crossover pathways, providing rapid access to fused, bridged, and spirocyclic architectures, including late‐stage scaffold diversification to diterpene‐like carbocyclic ...
Jacop Rydén, Eilidh Young, Wilma Olsson, Eskil Flodén, Mattias Tan, Sebastian Clementson   +5 more
wiley   +2 more sources

Comparison of Effectiveness between Combination of Beta-Lactam with Azyhtromycin or Levofloxacin for Adult Pneumonia Patients

Pharmacology and Clinical Pharmacy Research, 2018
Treatment for pneumonia has always been a challenge due to the difficulties in diagnosis and the growing incidence of antibiotic resistance. Beta-lactam antibiotics are the first line treatment for pneumonia.
Gina Arifah, Eli Halimah, Rizky Abdulah
doaj   +1 more source