Results 91 to 100 of about 89,494 (296)

Impact of Timing of Beta-Lactam Therapeutic Drug Monitoring and Therapy Adjustment in Critically Ill Patients

open access: yesAntibiotics
Purpose: To assess the impact of beta-lactam therapeutic drug monitoring (TDM) timing and therapy adjustment on clinical cure and 30-day mortality. Methods: This was a prospective study of critically ill patients admitted to the University of Florida ...
Mohammad H. Alshaer   +12 more
doaj   +1 more source

Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection [PDF]

open access: yes, 2017
Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam ...
Helps, Alieen   +5 more
core   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

open access: yesChemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati   +4 more
wiley   +1 more source

ftsI mutations versus beta-lactamase (blaTEM) production in beta-lactam resistance of Haemophilus influenzae: results from an university hospital in Istanbul

open access: yesJournal of Global Antimicrobial Resistance
AIM: To determine in vitro susceptibilities of H. influenzae strains and to reveal the beta-lactam resistance mechanisms involved in those resistant to beta-lactams in our center. METHODS: Antibiotic susceptibilities of 122 H. influenzae isolated in 2022
Meltem Sarı Küçükerol   +2 more
doaj   +1 more source

A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and ß-lactam resistance genes in the gut microbiota [PDF]

open access: yes, 2014
peer-reviewedBackground: The potential for the human gut microbiota to serve as a reservoir for antibiotic resistance genes has been the subject of recent discussion. However, this has yet to be investigated using a rapid PCR-based approach.
Cotter, Paul D.   +4 more
core   +1 more source

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

open access: yesChemistry – A European Journal, EarlyView.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini   +3 more
wiley   +1 more source

Procalcitonin predicts response to beta-lactam treatment in hospitalized children with community-acquired pneumonia.

open access: yesPLoS ONE, 2012
BackgroundAntibiotic treatment of community-acquired pneumonia (CAP) in children remains mostly empirical because clinical and paraclinical findings poorly discriminate the principal causes of CAP. Fast response to beta-lactam treatment can be considered
Jérémie F Cohen   +5 more
doaj   +1 more source

Prevalence of gram-negative infections in cervico-facial sepsis [PDF]

open access: yes, 2019
Magister Chirurgiae Dentium (MChD)In cervico-facial sepsis a substantial proportion of organisms are normally gram-negative staining of which the majority are anaerobes (Boyanova 2006 and Sanchez 2010).
Barnard, Neil
core  

Iridium‐Catalyzed Linear‐Selective sp3 C−H Alkylation of N‐Methylamides Using Alkenes Enabled by Diphosphite Ligands

open access: yesChemistry – A European Journal, EarlyView.
An iridium‐catalyzed linear‐selective sp3 C─H alkylation of N‐methylamides with alkenes is described. This method tolerates various N‐methylacetamide derivatives and has a broad alkene scope. Mechanistic studies were also conducted. Internal alkenes can also be used through in situ consecutive alkene isomerization.
Haluhi Takahashi, Takanori Shibata
wiley   +1 more source

Target Fidelity and Failure: Structure–Activity Relationship of High-Molecular-Mass Penicillin-Binding Proteins (HMM-PBPs) in Refractory Granulicatella adiacens Endocarditis

open access: yesAntibiotics
Background/Objectives: Granulicatella adiacens infective endocarditis is conventionally managed with penicillin, ampicillin, or ceftriaxone in combination with gentamicin, although double beta-lactam regiments have been proposed a safer alternative to ...
Paola Conti   +8 more
doaj   +1 more source

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