Results 51 to 60 of about 1,013,196 (143)

Diagnosis, evaluation, and management of acute kidney injury : a KDIGO summary (part 1) [PDF]

, 2013
Acute kidney injury (AKI) is a common and serious problem affecting millions and causing death and disability for many. In 2012, Kidney Disease: Improving Global Outcomes completed the first ever, international, multidisciplinary, clinical practice ...
Kellum, John A, Lameire, Norbert
core   +3 more sources

The Beta Lactam Antibiotics as an Empirical Therapy in a Developing Country: An Update on Their Current Status and Recommendations to Counter the Resistance against Them.

Journal of clinical and diagnostic research : JCDR, 2013
In a developing country like India, where the patients have to bear the cost of their healthcare, the microbiological culture and the sensitivity testing of each and every infection is not feasible.
B. Thakuria, K. Lahon
semanticscholar   +1 more source

Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance. [PDF]

, 2018
Bifidobacterium species are important commensals capable of dominating the infant gut microbiome, in part by producing acids that suppress growth of other taxa.
Ahmad, SM, Akre, Samir, Huda, M Nazmul, Liu, Jinxin, Maldonado-Gomez, Maria X, Mills, David A, Stephensen, Charles B, Taft, Diana H   +7 more
core   +1 more source

Identifying patients at risk for augmented renal clearance in the ICU : limitations and challenges [PDF]

, 2013
Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal.
Carlier, Mieke, De Waele, Jan
core   +2 more sources

The Mechanism of Heterogeneous Beta-Lactam Resistance in MRSA: Key Role of the Stringent Stress Response

PLoS ONE, 2013
All methicillin resistant S. aureus (MRSA) strains carry an acquired genetic determinant – mecA or mecC - which encode for a low affinity penicillin binding protein –PBP2A or PBP2A′ – that can continue the catalysis of peptidoglycan transpeptidation in ...
Choonkeun Kim, Michael M. Mwangi, M. Chung, Catarina Milheirço, H. de Lencastre, A. Tomasz   +5 more
semanticscholar   +1 more source

Insights from Modeling the 3D Structure of New Delhi Metallo-β-Lactamse and Its Binding Interactions with Antibiotic Drugs [PDF]

, 2010
New Delhi metallo-beta-lactamase (NDM-1) is an enzyme that makes bacteria resistant to a broad range of beta-lactam antibiotic drugs. This is because it can inactivate most beta-lactam antibiotic drugs by hydrolyzing them.
A Tamilselvi, AT Laurie, B Tang, D Xu, D Yong, DM Livermore, GM Morris, H Giamarellou, H Gui, H Wei, HB Shen, HC Maltezou, I Garcia-Saez, JF Wang, JF Wang, JF Wang, JF Wang, JF Wang, JF Wang, JF Wang, JF Wang, JF Wang, JF Wang, JF Wang, JF Wang, JF Wang, JF Wang, Jing-Fang Wang, K Gong, KC Chou, KC Chou, KC Chou, KC Chou, KC Chou, KC Chou, KC Chou, KC Chou, KC Chou, KC Chou, Keertan Dheda, KK Kumarasamy, Kuo-Chen Chou, L Li, L Poirel, NO Concha, P Benkert, P Ricchiuto, QK Zeng, QS Du, QS Du, RA Laskowski, RB Huang, RX Gu, S Wu, T Magdziarz, V Colotta, X Guo, Y Wang, Y Zhang, Y Zhang, Z Wang   +60 more
core   +3 more sources

Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy

The World Allergy Organization Journal, 2013
Antibiotics are used extensively in the treatment of various infections. Consequently, they can be considered among the most important agents involved in adverse reactions to drugs, including both allergic and non-allergic drug hypersensitivity [J ...
M. Sánchez-Borges, B. Thong, M. Blanca, L. Ensina, S. González-Díaz, P. Greenberger, E. Jares, Y. Jee, Luciana Kase-Tanno, D. Khan, Jungwon Park, W. Pichler, A. Romano, M. T. Jaén   +13 more
semanticscholar   +1 more source

Historical Review of the Penicillin and Related Compounds (β – Lactams) [PDF]

, 2018
In spite of  the old age of beta lactam, they continue to provide good health and preventing human diseases by virtue of  industrial production and discoveries of small new beta-lactam group of secondary metabolite.  Antibiotic resistance in bacteria has
Luma Salman Abd
core   +2 more sources

Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review

Annals of Intensive Care, 2012
The pharmacokinetics of beta-lactam antibiotics in intensive care patients may be profoundly altered due to the dynamic, unpredictable pathophysiological changes that occur in critical illness.
F. Sime, M. Roberts, S. Peake, J. Lipman, J. Roberts   +4 more
semanticscholar   +1 more source

Continuous beta-lactam infusion in critically ill patients: the clinical evidence

Annals of Intensive Care, 2012
There is controversy over whether traditional intermittent bolus dosing or continuous infusion of beta-lactam antibiotics is preferable in critically ill patients. No significant difference between these two dosing strategies in terms of patient outcomes
M. Abdul-Aziz, J. Dulhunty, R. Bellomo, J. Lipman, J. Roberts   +4 more
semanticscholar   +1 more source