Results 131 to 140 of about 49,830 (257)

Impact of a Rapid Change in Beta-lactam Resistance Epidemiology on the Management of Patients With Bloodstream Infections. [PDF]

Open Forum Infect Dis
Bobbitt L, Tao L, Ereshefsky B, Ing A, Humphries R.   +4 more
europepmc   +1 more source

Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Klebsiella pneumoniae is a pathogen associated with healthcare‐acquired infections and antimicrobial resistance (AMR) to beta‐lactams and carbapenems. Although wild animals are not typically exposed to antibiotics, they can harbour resistant strains. The European hedgehog (Erinaceus europaeus) is increasingly found in urban areas,
Biel Garcias, Chiara Seminati, Carolin M. Kobras, Samuel K. Sheppard, Rafael A. Molina‐López, Laila Darwich   +5 more
wiley   +1 more source

Targeting multi-drug resistant pathogens with synergistic beta-lactams and beta-lactam inhibitor combinations

Journal of Biological Methods
Background: Infections caused by multidrug-resistant organisms pose a significant global health challenge due to the limited therapeutic options available. Synergistic drug combinations are often employed to enhance treatment efficacy. Because peptidoglycan is unique to prokaryotes, many studies focus on combinations that include beta-lactam ...
openaire   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

A Standards‐Based, Cloud‐Hosted CDS System for Gonorrhea Treatment and HIV Screening

Learning Health Systems, Volume 10, Issue 4, October 2026.
ABSTRACT Objective Neisseria gonorrhoeae (or gonococcus, GC) infections have increased in incidence and antibiotic resistance, prompting updates to management guidelines. Additionally, patients with recent GC infections have been identified as a target population for human immunodeficiency virus (HIV) screening and prevention. With the rapidly changing
Edna Shenvi, Aziz Boxwala, Sarah Shaw, Andre Berro, Saugat Karki, Matthew Pooser, Jane E. Yang, Gema Dumitru, Jeanne Ocampo, Amrita Tailor, Sanjat Kanjilal, Carlos Paredes, Ritche Hao, Nitu Kashyap, David Liebovitz, Alejandro Pérez   +15 more
wiley   +1 more source

Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen <i>Haemophilus influenzae</i>. [PDF]

Antimicrob Agents Chemother
Petersen S, Diricks M, Utpatel C, Schulenburg H, Merker M.   +4 more
europepmc   +1 more source

Comparing Chemoenzymatic and Conventional Synthetic Strategies to Wall Teichoic Acid Peptidoglycan Fragments

Israel Journal of Chemistry, Volume 66, Issue 5, September 2026.
The Gram‐positive bacteria, Staphylococcus aureus, contain wall teichoic acid (WTA, a glycopolymer (green and yellow)) is a virulence factor in their cell wall. Synthesis of the peptidoglycan‐(PG)‐WTA conjugate (blue squares) was developed via the phospho‐donor and PG acceptor (structures at the bottom right).
Min Liu, Kathleen C. Stathoulopoulos, Catherine Leimkuhler Grimes   +2 more
wiley   +1 more source

The continued evolution of the L2 cephalosporinase in Stenotrophomonas maltophilia: a key driver of beta-lactam resistance. [PDF]

Biochem J
Sapula SA, Wang Y, Hart BJ, Whittall JJ, Venter H.   +4 more
europepmc   +1 more source

Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli. [PDF]

Nat Commun, 2019
Caveney NA, Caballero G, Voedts H, Niciforovic A, Worrall LJ, Vuckovic M, Fonvielle M, Hugonnet JE, Arthur M, Strynadka NCJ.   +9 more
europepmc   +1 more source

Prevalence and Characteristics of Salmonella spp. by Production Stage in Integrated Broiler Operations in Korea

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Vertically integrated broiler production systems may facilitate the dissemination of Salmonella throughout the production chain. This study demonstrates that Salmonella persists and spreads across all stages of integrated broiler production, highlighting the need for rigorous biosecurity, hygiene and continuous monitoring throughout the entire ...
Hyeong Jeong Choi, Young Ju Lee
wiley   +1 more source