Results 111 to 120 of about 49,413 (255)

Benefits and Harms of Antenatal/Intrapartum Screening for Maternal Group B Streptococcus and Use of Intrapartum Antibiotic Prophylaxis Versus Risk‐Based Protocols or No Intervention: A Rapid Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim To synthesise evidence on the effectiveness, harms and benefits of different approaches to prevent early‐onset Group B Streptococcus (EOGBS) and identify gaps in short and longer‐term outcomes. Methods A two‐phase rapid review. Phase 1 included an overview of systematic reviews (SRs).
Pauline Campbell, Cathryn Broderick, Candida Fenton, Bridget Davis, Wei Xu, Alex Todhunter‐Brown, Narendra Aladangady, Richard F. Chin, Rosie Hill, Ryan Kean, Charlotte‐Eve Short, Julie Cowie, NESSIE—NIHR Evidence Synthesis Scotland InitiativE   +12 more
wiley   +1 more source

Prediction of antimicrobial susceptibility of pneumococci based on whole-genome sequencing data: a direct comparison of two genomic tools to conventional antimicrobial susceptibility testing

Journal of Clinical Microbiology
Determination of antimicrobial resistance (AMR) in pneumococcal isolates is important for surveillance purposes and in a clinical context. Antimicrobial susceptibility testing (AST) of pneumococci is complicated by the need for exact minimal inhibitory ...
Gerardo J. Sanchez, Lize Cuypers, Lies Laenen, Peter Májek, Katrien Lagrou, Stefanie Desmet   +5 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Impact of beta-lactam allergy labels on bone marrow transplant patients

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Approximately 95% of patients with a beta-lactam allergy noted in their medical record are not truly allergic when tested. These patients may unnecessarily avoid first-line antibiotics, resulting in increased treatment failure, higher costs ...
Benjamin M. Haxby, Kendall J. Tucker, Caitlin M. McCracken, YoungYoon Ham, Jon P. Furuno, Jessina C. McGregor   +5 more
doaj   +1 more source

Beta-Lactam Resistance in Enterobacterales

Gastroenterology: Medicine & Research, 2022
openaire   +1 more source

Clinical guideline highlights for the hospitalist: Recommendations for pneumonia in hospitalized children with neurologic impairment

Journal of Hospital Medicine, Volume 21, Issue 6, Page 657-659, June 2026.
Elizabeth L. Nichols, J. Andrew Watson
wiley   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, EarlyView.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Quality and Consistency of Penicillin Allergy Delabelling Guidelines: A Systematic Review

Clinical &Experimental Allergy, EarlyView.
Eighteen penicillin allergy delabelling guidelines from 12 countries were reviewed. There is consensus for staged risk‐based testing, with emerging support for direct oral challenge in low‐risk patients and expanded non‐specialist roles. Overall guideline quality was low, with major gaps in methodological rigour, stakeholder involvement, and ...
Jessie He, Marina Guirguis, Sankare Devanandan, Rani Scott‐Farmer, Sandra Vale, Michaela Lucas, Jennifer J. Koplin, Catherine J. Hornung, Sandra M. Salter   +8 more
wiley   +1 more source

Patch Testing in Paediatric Drug Hypersensitivity Reactions: Current Evidence and Clinical Implications

Contact Dermatitis, EarlyView.
ABSTRACT Drug hypersensitivity reactions (DHRs) are common in children and are diagnostically challenging, with cutaneous manifestations being the most common presentation. Patch testing (PT) is a well‐established tool for investigating delayed T‐cell‐mediated reactions and is widely used in patients with contact dermatitis.
Gabriele Simonetti, Francesco Catamerò, Giulia Liccioli, Leonardo Tomei, Simona Barni, Mattia Giovannini, Lucrezia Sarti, Francesca Mori   +7 more
wiley   +1 more source

Pneumococcus morphogenesis and resistance to beta-lactams

Morphogenèse du pneumocoque et résistance aux bêta-lactamines Streptococcus pneumoniae, le pneumocoque, est une bactérie pathogène qui entraîne le décès de plus d'un million et demi de personnes dans le monde chaque année. Les β-lactamines sont très utilisées pour traiter les infections à pneumocoques.
openaire   +2 more sources