Results 161 to 170 of about 78,679 (204)
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Beta-lactams against methicillin-resistant Staphylococcus aureus.
Current opinion in pharmacology, 2005Methicillin-resistant Staphylococcus aureus (MRSA) have developed resistance to virtually all non-experimental antibiotics. They are intrinsically resistant to beta-lactams by virtue of newly acquired low-affinity penicillin-binding protein 2A (PBP2A). Because PBP2A can build the wall when other PBPs are blocked by beta-lactams, designing beta-lactams ...
Guignard, Bertrand +2 more
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Mechanisms of beta-lactam resistance inHaemophilus influenzae
European Journal of Clinical Microbiology & Infectious Diseases, 1988Haemophilus influenzae has become increasingly resistant to beta-lactam antibiotics. Three major mechanisms, both enzymatic and non-enzymatic, are involved. Enzymatic resistance is mainly due to production of a TEM-1 plasmid-mediated beta-lactamase, and in some cases to a new enzyme ROB-1.
L, Gutmann +3 more
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Beta-Lactam Resistance in Anaerobic Bacteria: a Review
Journal of Chemotherapy, 1996The majority of the human microflora consists of anaerobic bacteria. Normally these bacteria have low pathogenicity, but under certain conditions, such as destruction of tissues and poor circulation or impaired host defense, they may cause serious infections. Bacteroides species are the most frequently isolated microorganisms from suppurative anaerobic
M, Hedberg, C E, Nord
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Oropharyngeal tularemia in beta lactam-resistant cervical lymphadenitis
The Turkish Journal of Ear Nose and Throat, 2011This study aims emphasize oropharyngeal tularemia in the differential diagnosis of infected lymphadenopathy in the neck region.Twenty patients (13 males, 7 females; mean age 23 years; range 9 to 43 years) diagnosed with tularemia among those who admitted to our clinic between October 2008 - October 2010 with the complaint of lymphadenopathy in the neck,
GARÇA, Mehmet Fatih +5 more
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Identifying Beta-Lactam Resistance with Neural Networks
2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2019Antibiotic resistant bacteria are an ever-present threat in today's society and matter of great concern for the medical and scientific communities. With the high frequency of mutations, and the ability to transfer genes across species, bacteria can acquire resistance to currently used antibiotics.
Cory Kromer-Edwards +5 more
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Chromosomal beta-lactam resistance in enterobacteria.
Scandinavian journal of infectious diseases. Supplementum, 1987Most enterobacterial species carry a chromosomal ampC beta-lactamase gene. In Escherichia coli and Shigella, expression from ampC is non-inducible and the beta-lactamase is synthesized at low levels. Mutations leading to increased beta-lactamase synthesis occur rather infrequently, making resistance to modern cephalosporins a rare event in these ...
S, Normark, S, Lindquist, F, Lindberg
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Mechanisms of resistance of enterococci to beta-lactam antibiotics
European Journal of Clinical Microbiology & Infectious Diseases, 1990Two mechanisms are responsible for resistance of enterococci to beta-lactam antibiotics: alterations of penicillin-binding proteins and production of a beta-lactamase. The latter has been found in a few clinical isolates of Enterococcus faecalis, whereas the former appears to account for resistance in most strains.
FONTANA, Roberta +3 more
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Resistance to beta-lactam antibiotics.
Cellular and molecular life sciences : CMLS, 2004beta-lactams have a long history in the treatment of infectious diseases, though their use has been and continues to be confounded by the development of resistance in target organisms. beta-lactamases, particularly in Gram-negative pathogens, are a major determinant of this resistance, although alterations in the beta-lactam targets, the penicillin ...
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Tigecycline: The answer to beta-lactam and fluoroquinolone resistance?
Journal of Infection, 2006Patients with serious bacterial infections such as intra-abdominal infections and complicated skin and soft tissue infections are often treated empirically because a delay in appropriate initial antimicrobial therapy has been shown to significantly increase morbidity and mortality.
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Mechanisms of resistance to beta-lactam antibiotics.
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1985The complex mechanism of resistance towards beta-lactam antibiotics in Gram-negative bacteria can be described by a simple equation in which the hydrolytic activity of the enzyme, the affinity to the penicillin binding protein in competition to the affinity to the beta-lactamase, the quantity of the enzyme and the ability of the drug to penetrate the ...
B, Wiedemann, R M, Tolxdorff-Neutzling
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