Wastewater from urban and rural areas was analyzed to investigate antimicrobial‐resistant bacteria and resistance genes. ESBL‐Escherichia coli and genes coding for clinically relevant resistances, namely, those to macrolides, carbapenems, and vancomycin, were higher in urban than in rural areas.
Maya Petricciuolo +7 more
wiley +1 more source
Frequency and characterization of β-lactam-resistant Escherichia coli from wild birds from Marmara Region in Turkey. [PDF]
Halaç B +9 more
europepmc +1 more source
Fungal‐Bacterial Interactions in Polymicrobial Infections: Hidden Threats
ABSTRACT Polymicrobial infections involving fungi and bacteria represent a major and increasingly recognized clinical challenge, in which interkingdom interactions significantly amplify disease severity, antimicrobial resistance, and treatment failure. Rather than passive co‐existence, fungal–bacterial communities form highly coordinated systems driven
Mohammad Javad Roustaye Gourabi +3 more
wiley +1 more source
Case Commentary: When one target is not enough-PBP3 insertions and target redundancy in <i>Escherichia coli</i>. [PDF]
Stellfox ME, Doi Y.
europepmc +1 more source
Salmonella enterica serovar Gallinarum–Pullorum isolated from chickens reveals a critical 89.13% prevalence of multidrug resistance. High phenotypic resistance to amoxicillin and tetracycline is genetically underpinned by a robust presence of resistance‐conferring genes (notably tetA, sul1, and blaCMY), highlighting a significant zoonotic threat to ...
Md. Masuk Rahman Kingshuk +3 more
wiley +1 more source
Individualizing beta-lactam dosing in real-world patients: lessons from a pharmacist-led programme implementation and evaluation. [PDF]
Pan S +6 more
europepmc +1 more source
Pharmacokinetic Analysis of Intravenous Push Cefepime in Critically Ill Patients With Sepsis
ABSTRACT Background Intravenous push (IVP) administration of cefepime increases ease of preparation and limits the need for small volume parenterals. The data on IVP pharmacokinetic/pharmacodynamic (PK/PD) parameters are limited, but may be especially relevant in critically ill patients with altered PK/PD for time‐dependent antibiotics like cefepime ...
Susan E. Smith +8 more
wiley +1 more source
Gut microbiome associations with acute malnutrition relapse in South Sudan. [PDF]
Yang K +15 more
europepmc +1 more source
Functional dynamics of water in New Delhi metallo‐β‐lactamase catalysis
Abstract Water plays a critical role in the hydrolysis of antibiotics by New Delhi metallo‐β‐lactamases (NDMs). The reaction proceeds through a nucleophilic attack on the β‐lactam ring, followed by cleavage of the C–N bond and formation of an anionic nitrogen intermediate. This intermediate is then protonated by a water molecule diffusing from the bulk
Palanisamy Kandhan +3 more
wiley +1 more source
COVID-19 pandemic-driven evolution of Klebsiella pneumoniae: rising resistance, genetic diversity, and virulence in a Brazilian tertiary hospital. [PDF]
Sales RO +8 more
europepmc +1 more source

