Results 161 to 170 of about 49,830 (257)

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Penicillin-binding proteins and bacterial resistance to beta-lactams [PDF]

Antimicrobial Agents and Chemotherapy, 1993
openaire   +2 more sources

On‐site pilot‐scale advanced oxidation pretreatment of hospital wastewater: assessment of pharmaceuticals, pathogens, antibiotic resistance genes and acute ecotoxicity

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 8, Page 1478-1491, August 2026.
Abstract BACKGROUND Hospital premises generate wastewater containing a wide spectrum of contaminants, such as pharmaceutically active compounds (PhACs), antibiotic resistance genes (ARGs) and pathogenic microorganisms, whilst plenty of them are classified under the antibiotic resistant bacteria (ΑRΒ) category.
Andreas Kaliakatsos, Iosifina Gounaki, Spyros Dokianakis, Georgios Gkotsis, Maria‐Christina Nika, Eleni Aleiferi, Athanasios S Stasinakis, Nikos Katsarakis, Nikolaos S Thomaidis, Thrassyvoulos Manios, Michalis S Fountoulakis, Danae Venieri   +11 more
wiley   +1 more source

Polymicrobial Extracellular Vesicles Reduce the Innate Immune Response of Human Cystic Fibrosis Bronchial Epithelial Cells

Journal of Extracellular Biology, Volume 5, Issue 8, August 2026.
ABSTRACT Chronic antibiotic‐resistant cystic fibrosis (CF) lung infections are the leading cause of death in adults with CF. Despite advances in highly effective modulator therapies, microbial communities persist in the CF lung. The pathogenesis of CF airway infections can be exacerbated by pathogens such as Pseudomonas aeruginosa, which communicates ...
Lily A. Charpentier, Roxanna L. Barnaby, Carolyn T. Roche, Byoung‐Kyu Cho, Prashant Kaushal, Young Ah Goo, Brad Vietje, Douglas J. Taatjes, Alix Ashare, Fabrice Jean‐Pierre, Bruce A. Stanton   +10 more
wiley   +1 more source

Streamlining antibiotic use in community acquired pneumonia: A quality improvement initiative

Journal of Hospital Medicine, Volume 21, Issue 8, Page 890-897, August 2026.
Visual Abstract Abstract Background Evidence suggests a 3‐day total duration and early transition to oral therapy is safe in hospitalized patients with community acquired pneumonia (CAP)—though such care is not standard in the United States. To implement these evidence‐based practices, a multidisciplinary group led by a hospitalist and antimicrobial ...
Claire E. Ciarkowski, Karen Howard, Hannah Imlay, Chaorong Wu, Christy L. Hopkins, Valerie M. Vaughn, Emily S. Spivak   +6 more
wiley   +1 more source

Occurrence of Antimicrobial Resistance in Kocuria rhizophila Bacteria Isolated From Salmo munzuricus (Teleostei: Salmonidae) Samples in Natural Resources

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
This study examined the antibiotic susceptibility of Kocuria rhizophila isolated from Salmo munzuricus samples taken from the Munzur River. The isolates are resistant to Penicillin G, moderately susceptible to gentamicin and tetracycline, and highly susceptible to amoxicillin and ampicillin.
Bülent KAR
wiley   +1 more source

Evolution of beta-lactam : resistance in Klebsiella pneumoniae

, 2010
K. pneumoniae is recognized as a common opportunistic pathogen. Numerous reports have been published worldwide on outbreaks in different healthcare settings. K. pneumoniae is inherently resistant to penicillins, including semisynthetic broad-spectrum penicillins. The drug of choice for empirical treatment is often a cephalosporin.
openaire   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Likelihood of aggressive PK/PD target attainment of continuous-infusion beta-lactams during the first week of treatment of febrile neutropenia: findings from a 1-year prospective, monocentric study in onco-haematological patients. [PDF]

J Antimicrob Chemother
Cojutti PG, Toschi A, Pasquini Z, Paolini S, Maffini E, Bonifazi F, Zinzani PL, Giannella M, Viale P, Pea F.   +9 more
europepmc   +1 more source

Seasonal Restructuring of Microbial Communities and Resistomes in the Shitalakshya River, Bangladesh Revealed by Shotgun Metagenomics

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Dry‐season pollutant concentration drives microbial restructuring in Bangladesh's Shitalakshya River, shifting communities from Myroides to stress‐tolerant genera while enriching metal resistance genes and efflux pumps, revealing non‐antibiotic co‐selection as a key driver of antimicrobial resistance in urban waters.
Muhammad Ehteshamul Haque, Md. Shaminur Rahman, Munawar Sultana, Anowara Begum   +3 more
wiley   +1 more source