Results 221 to 230 of about 49,413 (255)
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Beta-lactams against methicillin-resistant Staphylococcus aureus.
Current opinion in pharmacology, 2005Methicillin-resistant Staphylococcus aureus (MRSA) have developed resistance to virtually all non-experimental antibiotics. They are intrinsically resistant to beta-lactams by virtue of newly acquired low-affinity penicillin-binding protein 2A (PBP2A). Because PBP2A can build the wall when other PBPs are blocked by beta-lactams, designing beta-lactams ...
Guignard, Bertrand +2 more
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Mechanisms of resistance to beta-lactam antibiotics.
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1985The complex mechanism of resistance towards beta-lactam antibiotics in Gram-negative bacteria can be described by a simple equation in which the hydrolytic activity of the enzyme, the affinity to the penicillin binding protein in competition to the affinity to the beta-lactamase, the quantity of the enzyme and the ability of the drug to penetrate the ...
B, Wiedemann, R M, Tolxdorff-Neutzling
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Resistance to beta-lactam antibiotics.
Cellular and molecular life sciences : CMLS, 2004beta-lactams have a long history in the treatment of infectious diseases, though their use has been and continues to be confounded by the development of resistance in target organisms. beta-lactamases, particularly in Gram-negative pathogens, are a major determinant of this resistance, although alterations in the beta-lactam targets, the penicillin ...
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Chromosomal beta-lactam resistance in enterobacteria.
Scandinavian journal of infectious diseases. Supplementum, 1987Most enterobacterial species carry a chromosomal ampC beta-lactamase gene. In Escherichia coli and Shigella, expression from ampC is non-inducible and the beta-lactamase is synthesized at low levels. Mutations leading to increased beta-lactamase synthesis occur rather infrequently, making resistance to modern cephalosporins a rare event in these ...
S, Normark, S, Lindquist, F, Lindberg
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Transfer of Beta-Lactam Antibiotic Resistance in Bacteroides
1993It is well known that Bacteroides fragilisand related species produce several kinds of beta-lactamases such as oxyiminocephalosporinase, penicillinase, and metallo-beta-lactamase, with some strains showing a particularly high resistance to beta-lactam antibiotics.
Kunitomo Watanabe, Kazue Ueno
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[Oropharyngeal tularemia in beta lactam-resistant cervical lymphadenitis].
Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, 2011Objectives: This study aims emphasize oropharyngeal tularemia in the differential diagnosis of infected lymphadenopathy in the neck region. Patients and Methods: Twenty patients 13 males, 7 females; mean age 23 years; range 9 to 43 years diagnosed with tularemia among those who admitted to our clinic between October 2008 - October 2010 with the ...
GARÇA, Mehmet Fatih +5 more
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Mechanisms of resistance to beta-lactam antibiotics.
Scandinavian journal of infectious diseases. Supplementum, 1991The use of new beta-lactam antibiotics has led to selection of novel forms of resistance. Newer-generation cephalosporins, ureidopenicillins and monobactams, but not carbapenems (e.g. imipenem), are labile to Class I chromosomal beta-lactamases and tend to select mutants of E. cloacae and P.
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[Mechanisms of resistance to beta-lactam antibiotics].
Infection, 1994Beta-lactam antibiotics share the structural feature of a beta-lactam ring. This feature is responsible for inhibition of bacterial cell wall synthesis. The target molecules are peptidoglycan cross-linking enzymes (e.g. transpeptidases and carboxypeptidases) which can bind beta-lactam antibiotics (penicillin binding proteins, PBP). Bacterial cell death
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