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Mechanisms of resistance to beta-lactam antibiotics.
Scandinavian journal of infectious diseases. Supplementum, 1991The use of new beta-lactam antibiotics has led to selection of novel forms of resistance. Newer-generation cephalosporins, ureidopenicillins and monobactams, but not carbapenems (e.g. imipenem), are labile to Class I chromosomal beta-lactamases and tend to select mutants of E. cloacae and P.
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[Mechanisms of resistance to beta-lactam antibiotics].
Infection, 1994Beta-lactam antibiotics share the structural feature of a beta-lactam ring. This feature is responsible for inhibition of bacterial cell wall synthesis. The target molecules are peptidoglycan cross-linking enzymes (e.g. transpeptidases and carboxypeptidases) which can bind beta-lactam antibiotics (penicillin binding proteins, PBP). Bacterial cell death
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Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1985
In 12 patients treated with cefsulodin for Pseudomonas aeruginosa infections, resistance to cefsulodin developed in the infecting strains of two patients who failed to improve clinically. In both cases, cross-resistance also appeared for a broad spectrum of new antipseudomonal beta-lactams, except imipenem.
S A, Lerner, J P, Quinn
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In 12 patients treated with cefsulodin for Pseudomonas aeruginosa infections, resistance to cefsulodin developed in the infecting strains of two patients who failed to improve clinically. In both cases, cross-resistance also appeared for a broad spectrum of new antipseudomonal beta-lactams, except imipenem.
S A, Lerner, J P, Quinn
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Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections
Antibiotics, 2023Eduardo Gómez-Conde +2 more
exaly
Beta‐lactam antibiotics: from antibiosis to resistance and bacteriology
Apmis, 2010Kalai Mathée
exaly