Results 11 to 20 of about 61,855 (219)

Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases [PDF]

Antimicrobial Agents and Chemotherapy, 1995
The effects of acidic conditions on activities of seven beta-lactamases--TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)--and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5.
S, Ohsuka, Y, Arakawa, T, Horii, H, Ito, M, Ohta   +4 more
openaire   +2 more sources

Beta-lactamase antimicrobial resistance in Klebsiella and Enterobacter species isolated from healthy and diarrheic dogs in Andhra Pradesh, India [PDF]

Veterinary World, 2017
Aim: The aim of this study was to characterize beta-lactamase antimicrobial resistance in Klebsiella and Enterobacter species isolated from healthy and diarrheic dogs in Andhra Pradesh. Materials and Methods: A total of 136 rectal swabs were collected
N. Mohammad Sharif, B. Sreedevi, R. K. Chaitanya, D. Sreenivasulu   +3 more
doaj   +1 more source

Combined effects of antibiotics and acidified nitrite on biofilm formation by beta-lactamase-producing uropathogenic bacteria

Zanco Journal of Medical Sciences, 2023
Background and objective: The increased prevalence of extended- spectrum beta-lactamase producing Enterobacteriaceae has increased the use of last-resort antimicrobial drugs like Carbapenems.
Hozan Yousif Hassan, Safaa Toma Hanna Aka, Aras Najmaddin Hamad, Salah Tofik Jalal Balaky   +3 more
doaj   +1 more source

Allergic Reactions and Cross-Reactivity Potential with Beta-Lactamase Inhibitors

Pharmacy, 2019
Although beta-lactam allergies are an emerging focus of stewardship programs and interventions, less is publicly released regarding allergies to beta-lactamase inhibitors. This review presents and evaluates the data regarding allergic reactions with beta-
Kayla R. Stover, Katie E. Barber, Jamie L. Wagner   +2 more
doaj   +1 more source

Prevalence of extended-spectrum beta-lactamases, AmpC beta-lactamase, and metallo-beta-lactamase producing Pseudomonas aeruginosa and Acinetobacter baumannii in an intensive care unit in a tertiary care hospital

Journal of the Scientific Society, 2013
Background: Resistance to broad-spectrum beta-lactams, mediated by extended-spectrum beta-lactamases (ESBL), AmpC beta-lactamase, and metallo-beta-lactamase (MBL) enzymes, is an increasing problem worldwide. Aim of the study: This study was undertaken to
Varun Goel, Sumati A Hogade, S G Karadesai   +2 more
doaj   +1 more source

Beta-lactamase resistance genes in Enterobacteriaceae from Nigeria

African Journal of Laboratory Medicine, 2022
Background: Beta-lactamase genes are one of the most important groups of antimicrobial resistance genes in human and animal health. Therefore, continuous surveillance of this group of resistance genes is needed for a better understanding of the local ...
Babafela B. Awosile, Michael Agbaje, Oluwawemimo Adebowale, Olugbenga Kehinde, Ezekiel Omoshaba   +4 more
doaj   +1 more source

Carriage of plasmidic ampc beta-lactamase producing escherichia coli in cattle and sheep and characterisation of the isolates in terms of antibiogram profiles, phylogeny and virulence [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020
AmpC type beta-lactamase enzyme production by Escherichia coli confers resistance to penicillin and cephalosporins including oxyiminocephalosporin, cephamycin and aztreonam (variably).
Faruk PEHLIVANOGLU, Dilek OZTURK, Hulya TURUTOGLU   +2 more
doaj   +1 more source

Molecular Glue Degraders of TEM β‐Lactamases by Periplasmic Protease DegP

Angewandte Chemie, EarlyView.
Molecular glues are developed that target TEM‐family β‐lactamases to the bacterial protease DegP for degradation. β‐Lactamase inhibitor tazobactam is identified as accelerating TEM β‐lactamase degradation by DegP, which is further enhanced by linkerless incorporation of dipeptides enriched among DegP substrates.
Emilia K. Taylor, Patricia Santos Barbosa, Tarini Kadambi, Frederik Eisele, Yiqiao Wang, Elisabete C. C. M. Moura, Timothy R. Walsh, Georgia L. Isom, Thomas Lanyon‐Hogg   +8 more
wiley   +2 more sources

Difluoromethylenation of Alkynes: Streamlined Access to Allyl Difluorides

Angewandte Chemie, EarlyView.
Stabilizing primary oxocarbenium in HF/pyridine unlocks a direct alkyne difluoromethylenation – an efficient route to synthetically‐relevant allyl difluorides in a single step. ABSTRACT A direct difluoromethylenation of alkynes has been developed using HF/pyridine as a dual acidic and fluorinating medium. The reaction proceeds via in situ generation of
Fabien Naullet, Sourav Mondal, Frédéric Guégan, Bastien Michelet, Sébastien Thibaudeau   +4 more
wiley   +2 more sources

Conformation‐Selective Binding Domains of Intramolecular Chemically Induced Protein Dimerisation Systems

Angewandte Chemie, EarlyView.
Intramolecular chemically induced dimerisation transforms FK506‐ and cyclosporine A‐responsive protein pairs into high‐affinity pseudo‐allosteric switches. Holo‐selective binders isolated by mRNA display convert these switches into gain‐of‐signal biosensors and ultrasensitive ELISAs, enabling direct quantification of both immunosuppressants in ...
Zhenling Cui, Zhong Guo, Yi Jin Liew, Alessandro T. Caputo, Maria M. Fiorito, Cagla Ergun Ayva, Roxane Mutschler, Mayra Barrios Leguarca, Sophia Newton, Gia Nghi Lam, Robert Speight, Brett McWhinney, Yanulla Essie Georges, Carel Pretorius, Jacobus P.J. Ungerer, Kirill Alexandrov   +15 more
wiley   +2 more sources