Results 31 to 40 of about 61,855 (219)

High burden of ESBL and carbapenemase-producing gram-negative bacteria in bloodstream infection patients at a tertiary care hospital in Addis Ababa, Ethiopia

PLoS ONE, 2023
Background Bloodstream infection due to beta-lactamase and carbapenemase-producing gram-negative bacteria poses a substantial challenge to the effectiveness of antimicrobial treatments.
Daniel Beshah, Adey Feleke Desta, Gurja Belay Woldemichael, Esmael Besufikad Belachew, Solomon Gizaw Derese, Tizazu Zenebe Zelelie, Zelalem Desalegn, Tesfaye Sisay Tessema, Solomon Gebreselasie, Tamrat Abebe   +9 more
doaj  

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

Advanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge, Xiangyang Ma, Jiyan Li, Mengxiang Wang, Fuping Lu, Yihan Liu, Lin Wang   +6 more
wiley   +1 more source

Investigation of Metallo-beta-lactamase Genes (L1 and NDM1) in Isolates of Stenotrophomonas maltophilia

Acta Medica Iranica, 2022
Stenotrophomonas maltophilia is resistant to a wide range of antibiotics. This study aimed to investigate the beta-lactamase, ESBL, and MBL enzymes and also L1and NDM1 genes in isolates of Stenotrophomonas maltophilia.
Rabeeh Izadi Amoli, Jamileh Nowroozi
doaj   +1 more source

GC-MS profiling, Beta-lactamase Inhibition Assay, and Molecular Docking Studies on Selected Medicinal Plants

UMYU Journal of Microbiology Research
Bacterial infections are continually developing resistance to conventional antibiotic agents, thereby prompting the search for bioactive compounds from plant parts that would serve as lead molecules in the discovery and development of new drugs.
Ubamaka W Ike, Osinachi Samdavid Okpara, Chidi Ijeoma Nosiri, G Enyinnaya Eze, Chinedu Aguwamba, Chinomso Friday Aaron, Okamgba, C. O., S C Okereke   +7 more
doaj   +1 more source

Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria

Journal of Biomedical Science, 2019
Background This study sought to develop new strategies for reverting the resistance of pathogenic Gram-negative bacilli by a combination of conventional antibiotics, potent permeabilizers and natural beta lactamase inhibitors enhancing the activity of ...
Hala A. Farrag, Nagwa Abdallah, Mona M. K. Shehata, Ebthag M. Awad   +3 more
doaj   +1 more source

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

Ceftolozane-tazobactam versus meropenem for definitive treatment of bloodstream infection due to extended-spectrum beta-lactamase (ESBL) and AmpC-producing Enterobacterales (“MERINO-3”): study protocol for a multicentre, open-label randomised non-inferiority trial

Trials, 2021
Background Extended-spectrum beta-lactamase (ESBL) and AmpC-producing Enterobacterales are common causes of bloodstream infection. ESBL-producing bacteria are typically resistant to third-generation cephalosporins and result in a sizeable economic and ...
Adam G. Stewart, Patrick N. A. Harris, Mark D. Chatfield, Roberta Littleford, David L. Paterson   +4 more
doaj   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Metallo-β-Lactamase and Extended-Spectrum-β-Lactamase Production by Serratia Strains [Letter]

Infection and Drug Resistance, 2020
Bhoj R Singh, 1 Shiv Varan Singh 2 1Division of Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar 243122, India; 2Division of Bacteriology and Mycology, ICAR-Indian Veterinary Research Institute, Izatnagar 243122, IndiaCorrespondence ...
Singh BR, Singh SV
doaj  

Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups

Angewandte Chemie International Edition, EarlyView.
A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari, Leon F. Schwarz, Luca Schlautmann, Kai Schließmann, Christopher Slotman, Nina von Felten, Claus‐Michael Lehr, Rolf Müller, Alexander F. Kiefer, Jörn Piel, Florian Hubrich   +10 more
wiley   +1 more source