Results 191 to 200 of about 52,329 (268)
α/β Hydrolases: Toward Unraveling Entangled Classification
ABSTRACT α/β Hydrolase‐like enzymes form a large and functionally diverse superfamily of proteins. Despite retaining a conserved structural core consisting of an eight‐stranded, central β‐sheet flanked with six α‐helices, they display a modular architecture allowing them to perform a variety of functions, like esterases, lipases, peptidases, epoxidases,
Fatih Ozhelvaci, Kamil Steczkiewicz
wiley +1 more source
Targeting beta-lactamase activity with Oxacyclohexadecan-2-one in carbapenem-resistant uropathogenic E. coli: A molecular simulation approach. [PDF]
Balaji P+5 more
europepmc +1 more source
Mineral formation by bacteria is a widespread, yet poorly understood, phenomenon, which finds many applications in the field of sustainable construction materials. Here, we provide insights into the physiological processes leading to non‐ureolytic biomineralisation, with acetate metabolism identified as a key driver in some environmental Bacillales ...
Michael Seidel+9 more
wiley +1 more source
Prevalence and antimicrobial resistance of extended spectrum beta-lactamase (ESBL) producing Klebsiella spp. in poultry meat. [PDF]
Tanni FY+8 more
europepmc +1 more source
Classification of beta-lactamases: groups 1, 2a, 2b, and 2b' [PDF]
Karen Bush
openalex +1 more source
Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review
Abstract In the past year, the European Medicines Agency (EMA), the Food and Drug Administration (FDA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) authorised 53 novel drugs. While the 2024 harvest is not as rich as in 2023, when 70 new chemical entities were approved, the number of ‘orphan’ drug authorisations in 2024 (21) is ...
Stavros Topouzis+16 more
wiley +1 more source
ABSTRACT Introduction Little is known about the epidemiology and management of gram‐negative bloodstream infections (GN‐BSIs) in patients after solid organ transplant (SOT). We describe epidemiology, treatment approaches, and outcomes in a subset of patients with SOT from a larger cohort with GN‐BSI. Methods This was a multicenter, retrospective cohort
Sarah B. Doernberg+11 more
wiley +1 more source
Current trends in the epidemiology of multidrug-resistant and beta-lactamase-producing Pseudomonas aeruginosa in Asia and Africa: a systematic review and meta-analysis. [PDF]
Salleh MZ+3 more
europepmc +1 more source