Results 291 to 300 of about 1,103,793 (328)
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Journal of Biomolecular Structure and Dynamics, 2020
Metallo-beta-lactamase (MBL) is a class of enzyme that catalyzes the hydrolysis of a broad range of beta-lactam antibiotics leading to the development of drug resistance in bacteria.
B. Gangadharappa +5 more
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Metallo-beta-lactamase (MBL) is a class of enzyme that catalyzes the hydrolysis of a broad range of beta-lactam antibiotics leading to the development of drug resistance in bacteria.
B. Gangadharappa +5 more
semanticscholar +1 more source
Beta-lactamase inhibitor combinations
Medical Clinics of North America, 1995The beta-lactamase inhibitor combinations present a novel approach to the problem of beta-lactamase-induced resistance to antibiotics. These agents are derived from the generally safe beta-lactam class of antibiotics. They are all principally excreted through the kidneys and require dosage adjustment in the face of significant renal insufficiency. They
J W, Sensakovic, L G, Smith
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Cryoenzymology of .beta.-lactamases
Biochemistry, 1987The cryoenzymology of several different beta-lactamases has been investigated. Particular attention has been paid to the experimental pitfalls of the technique. These include such factors as false bursts at the start of the reaction, instability of the enzymes during turnover, and Km values so high that little of the enzyme is present as a complex ...
S J, Cartwright, S G, Waley
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Effect of beta-lactamase inhibitors on beta-lactamases from anaerobic bacteria
European Journal of Clinical Microbiology & Infectious Diseases, 1992Three beta-lactamase inhibitors in clinical use--clavulanic acid, sulbactam and tazobactam--were investigated for their activity on beta-lactamases from Bacteroides uniformis, Clostridium butyricum and Fusobacterium nucleatum. Purification of the beta-lactamases was carried out by anion-exchange chromatography, gel filtration and FPLC. The inactivation
M, Hedberg +3 more
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Zinc Beta Lactamase Superfamily
2013The metallo-beta-lactamase superfamily was first defined in 1997 on the basis of a sequence alignment. The members of this superfamily are characterized by the presence of a common alpha-beta-beta-alpha fold and share five conserved motifs: Asp84, His116-Xaa-His118-Xaa-Asp120-His121, His196, Asp221 and His263, which are (with the exception of Asp84 ...
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Beta-lactamases and beta-lactamase inhibitors.
International journal of antimicrobial agents, 1999Penicillin, the first of the beta-lactam antibiotics, was introduced into medical practice in the 1940s. Since then, a large number of different beta-lactams, including penicillins, cephalosporins, monobactams, and carbapenems, have been developed, all of which are structurally related through the presence of a core beta-lactam ring. Resistance to beta-
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Beta-Lactamase Stability of Faropenem
Chemotherapy, 2003Faropenem (FAR) is an orally available member of the penem class unique among carbapenems and other available β-lactams. This study compared FAR to cephalosporins and imipenem with respect to β-Iactamase (BLA) stability and emergence of resistance to <i>Staphylococcus aureus </i>and <i>Escherichia coli</i>.
A, Dalhoff, T, Nasu, K, Okamoto
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Presse medicale (Paris, France : 1983), 1997
BETA-LACTAMASE: The capacity to produce beta-lactamase, an enzyme which hydrolyses penicillin and cephalosporines, is the main source of bacterial resistance to beta-lactamines, thus the important contribution of beta-lactamase inhibitors (clavanulanic acid, sulbactam and tazobactam).Beta-lactamase inhibitors inactivate these enzymes and, in ...
O, Launay +3 more
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BETA-LACTAMASE: The capacity to produce beta-lactamase, an enzyme which hydrolyses penicillin and cephalosporines, is the main source of bacterial resistance to beta-lactamines, thus the important contribution of beta-lactamase inhibitors (clavanulanic acid, sulbactam and tazobactam).Beta-lactamase inhibitors inactivate these enzymes and, in ...
O, Launay +3 more
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Medicinal research reviews, 1984
In summary, Table XVI shows the inhibition profiles of representative beta-lactamases from each major class of Richmond and Sykes. Either resistance (R) or sensitivity (S) is given as a general guide to the type of compounds likely to inhibit each class.
S J, Cartwright, S G, Waley
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In summary, Table XVI shows the inhibition profiles of representative beta-lactamases from each major class of Richmond and Sykes. Either resistance (R) or sensitivity (S) is given as a general guide to the type of compounds likely to inhibit each class.
S J, Cartwright, S G, Waley
openaire +1 more source