Results 181 to 190 of about 34,488 (237)

[Inhibitors of beta-lactamases in the genus Haemophilus].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 1999
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beta-lactamase epidemiology and the utility of established and novel beta-lactamase inhibitors

Expert Opinion on Investigational Drugs, 2000
beta-Lactamase inhibitor:beta-lactam combinations remain one of the most successful strategies for the treatment of bacterial infections. Over the last 20 years the number and diversity of serine and metallo active site beta-lactamases has increased dramatically. This review highlights some of the new additions to the beta-lactamase arena and discusses
David J Payne, J H Bateson
exaly   +3 more sources

Nanomolar Inhibitors of AmpC β-Lactamase [PDF]

Journal of the American Chemical Society, 2002
beta-lactamases are the most widespread resistance mechanism to beta-lactam antibiotics, such as the penicillins and the cephalosporins. In an effort to combat these enzymes, a combination of stereoselective organic synthesis, enzymology, microbiology, and X-ray crystallography was used to design and evaluate new carboxyphenyl-glycylboronic acid ...
MORANDI, federica, CASELLI, Emilia, MORANDI, Stefania, P. J. Focia, J. Blazquez, B. K. Shoichet, PRATI, Fabio   +6 more
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Docking and Molecular Dynamic of Microalgae Compounds as Potential Inhibitors of Beta-Lactamase [PDF]

International Journal of Molecular Sciences, 2022
Bacterial resistance is responsible for a wide variety of health problems, both in children and adults. The persistence of symptoms and infections are mainly treated with β-lactam antibiotics.
Roberto Carlos Pestana Nobles, Yani Aranguren, Daniel Kuroda   +2 more
exaly   +3 more sources

Beta-lactams and Beta-lactamase-inhibitors in current- or potential-clinical practice: A comprehensive update [PDF]

Critical Reviews in Microbiology, 2009
The use of successive generations of beta-lactams has selected successive generations of beta-lactamases including CTX-M ESBLs, AmpC beta-lactamases, and KPC carbapenamases in Enterobacteriaceae. Moreover, this cephalosporin resistance, along with rising
Haris M Khan, P M Hawkey
exaly   +2 more sources

Beta-lactamase inhibitor combinations

Medical Clinics of North America, 1995
The beta-lactamase inhibitor combinations present a novel approach to the problem of beta-lactamase-induced resistance to antibiotics. These agents are derived from the generally safe beta-lactam class of antibiotics. They are all principally excreted through the kidneys and require dosage adjustment in the face of significant renal insufficiency. They
J W, Sensakovic, L G, Smith
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Newer Penicillins and Beta-Lactamase Inhibitors

Infectious Disease Clinics of North America, 1989
Penicillins continue to be essential antibiotics for the treatment and prophylaxis of many infectious diseases. Recent advances have resulted in compounds with favorable new antimicrobial and pharmacologic properties. This article reviews the spectrum of activity, toxicity, pharmacokinetics, and clinical uses of the extended spectrum penicillins and ...
L M, Bush, J, Calmon, C C, Johnson
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