Results 201 to 210 of about 34,488 (237)
Some of the next articles are maybe not open access.
Pharmacokinetic properties of beta-lactamase inhibitors.
International journal of clinical pharmacology and therapeutics, 1999In recent years, the use of combinations of beta-lactam-antibiotics with beta-lactamase inhibitors has been proven to be a useful and effective strategy to improve upon the therapeutic value of beta-lactam antibiotics. The objective of this article is to evaluate the pharmacokinetic properties of three commercially available beta-lactamase inhibitors ...
A, de la Pena, H, Derendorf
openaire +1 more source
Nanomolar beta-lactamase inhibitors
2003New .alpha.-boronated N-alkylamides, R1C(O)NHCHR2B(OH)2 (R1 = H, organyl, excluding R1 = Me, Ph; R2 = heterocyclyl, cycloalkenyl, alkenyl, alkyl), preferably N-acyl-3-aminomethylbenzoates (.alpha.R)-RC(O)NHCH[B(OH)2]-1,3-C6H4X [15-17; X = CO2H, R = Me, 2-thienylmethyl, 3-(2-chlorophenyl)-5-methylisoxazol-4-yl; 21, X = H, R = 2-thienylmethyl], designed ...
SHOICHET B. K, PRATI, Fabio
openaire +1 more source
A 2018–2019 patent review of metallo beta-lactamase inhibitors
Expert Opinion on Therapeutic Patents, 2020Sooraj Baijnath +2 more
exaly
Development of beta-lactamase inhibitors.
The Journal of reproductive medicine, 1990The resistance of bacteria to beta-lactam antibiotics was first associated with the production of the enzyme beta-lactamase as long ago as 1940. Since then, increasing numbers of beta-lactamase-producing bacteria capable of inactivating penicillins and cephalosporins have been isolated clinically.
openaire +1 more source
Evolution of beta-lactamase inhibitors.
Pharmacotherapy, 1991After the introduction of penicillin G into therapeutics, bacteria became increasingly resistant to this penicillin and subsequent beta-lactam antibiotics. The major cause of this resistance is beta-lactamase, an enzyme produced by the bacterium, that destroys the antibiotic before it reaches its target within the bacterial cell.
openaire +1 more source