Results 1 to 10 of about 1,053,591 (371)
Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding [PDF]
Nature Communications, 2023 There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast +13 more
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An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains [PDF]
Microbiology Spectrum, 2022 Bacterial genes coding for antibiotic resistance represent a major issue in the fight against bacterial pathogens. Among those, genes encoding beta-lactamases target penicillin and related compounds such as carbapenems, which are critical for human ...
Valérian Lupo +6 more
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Extended-Spectrum Beta-Lactamases [PDF]
Canadian Journal of Infectious Diseases and Medical Microbiology, 2006 The definition of extended-spectrum beta-lactamases (ESBLs) has expanded rapidly, in terms of both the number and the variety of enzymes. Bacteria bearing plasmidic ESBLs are spreading widely throughout the world.
Kevin R Forward
doaj +2 more sources
Journal of the Scientific Society, 2013 Background: Resistance to broad-spectrum beta-lactams, mediated by extended-spectrum beta-lactamases (ESBL), AmpC beta-lactamase, and metallo-beta-lactamase (MBL) enzymes, is an increasing problem worldwide. Aim of the study: This study was undertaken to
Varun Goel +2 more
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Extended-spectrum beta-lactamases [PDF]
Antimicrobial Agents and Chemotherapy, 1989 A, Philippon, R, Labia, G, Jacoby
openaire +3 more sources
More extended-spectrum beta-lactamases [PDF]
Antimicrobial Agents and Chemotherapy, 1991 G A, Jacoby, A A, Medeiros
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Beta-lactamases from Yersinia enterocolitica.
Journal of general microbiology, 1975 Two beta-lactamases, A and B, have been shown to be present in a strain of Yersinia enterocolitica (w222). Beta-Lactamase A hydrolyses a variety of penicillins and cephalosporins. This enzyme is sensitive to thiol reagents, is only partially inhibited by 0-1 mM-cloxacillin and has a molecular weight of approximatley 20,000.beta-Lactamase B shows strong
Cornelis, G., Abraham, E. P.
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Antimicrobial resistance of gram-negative pathogens isolated from hospitalized patients in Rostov region [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2020 Objective. To evaluate resistance rates to carbapenems and III–IV generation cephalosporins among gramnegative bacteria, including production of carbapenemases and extended-spectrum beta-lactamases (ESBL). Materials and Methods.
Kutsevalova O.Yu. +4 more
doaj +1 more source
Antimicrobial Agents and Chemotherapy, 2020 QPX7728 is a new ultrabroad-spectrum inhibitor of serine and metallo-beta-lactamases (MBLs) from a class of cyclic boronates that gave rise to vaborbactam.
Ruslan Tsivkovski +2 more
semanticscholar +1 more source
Journal of Medicinal Chemistry, 2020 Despite major advances in the beta-lactamase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced. Most important among these are the Class B (metallo) enzyme NDM-1 of Enterobacteriaceae and the Class D (OXA ...
S. Hecker +16 more
semanticscholar +1 more source