Results 1 to 10 of about 1,206,616 (257)

An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains [PDF]

Microbiology Spectrum, 2022
Bacterial genes coding for antibiotic resistance represent a major issue in the fight against bacterial pathogens. Among those, genes encoding beta-lactamases target penicillin and related compounds such as carbapenems, which are critical for human ...
Valérian Lupo, Paola Sandra Mercuri, Jean-Marie Frère, Bernard Joris, Moreno Galleni, Denis Baurain, Frédéric Kerff   +6 more
doaj   +2 more sources

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding [PDF]

Nature Communications, 2023
There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz   +13 more
doaj   +2 more sources

Prevalence of extended-spectrum beta-lactamases, AmpC beta-lactamase, and metallo-beta-lactamase producing Pseudomonas aeruginosa and Acinetobacter baumannii in an intensive care unit in a tertiary care hospital

Journal of the Scientific Society, 2013
Background: Resistance to broad-spectrum beta-lactams, mediated by extended-spectrum beta-lactamases (ESBL), AmpC beta-lactamase, and metallo-beta-lactamase (MBL) enzymes, is an increasing problem worldwide. Aim of the study: This study was undertaken to
Varun Goel, Sumati A Hogade, S G Karadesai   +2 more
doaj   +2 more sources

Antimicrobial resistance of gram-negative pathogens isolated from hospitalized patients in Rostov region [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2020
Objective. To evaluate resistance rates to carbapenems and III–IV generation cephalosporins among gramnegative bacteria, including production of carbapenemases and extended-spectrum beta-lactamases (ESBL). Materials and Methods.
Kutsevalova O.Yu., Kozel Yu.Yu., Rozenko D.A., Martynov D.V., Korshunkova O.V.   +4 more
doaj   +1 more source

Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases

Antimicrobial Agents and Chemotherapy, 2020
QPX7728 is a new ultrabroad-spectrum inhibitor of serine and metallo-beta-lactamases (MBLs) from a class of cyclic boronates that gave rise to vaborbactam.
Ruslan Tsivkovski, M. Totrov, O. Lomovskaya   +2 more
semanticscholar   +1 more source

Phenotypic Characterization of Extended-Spectrum Beta-Lactamases and Metallo-Beta-Lactamase of Multi Drug Resistant Acinetobacter baumannii Causing Nosocomial Infections in Erbil City

Al-Mustansiriyah Journal of Science, 2020
Background: Resistance to broad‑spectrum beta‑lactams, mediated by extended‑spectrum beta‑lactamases, and metallo‑beta‑lactamase enzymes, is an increasing problem worldwide.
Sakar Bakr Smail, Kamal I. AL-OTRACHI
doaj   +1 more source

Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases

Antimicrobial Agents and Chemotherapy, 2020
QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor, with potent inhibition of key serine and metallo-beta-lactamases being observed in biochemical assays.
O. Lomovskaya, Ruslan Tsivkovski, Kirk J. Nelson, Debora Rubio-Aparicio, Dongxu Sun, M. Totrov, M. Dudley   +6 more
semanticscholar   +1 more source

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) [PDF]

, 2016
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.
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core   +7 more sources

Бета-лактамази ентеробактерій: загальна характеристика, механізми та регіональні особливості розповсюдження

Annals of Mechnikov's Institute, 2022
The problem of the formation and spread of resistance to β-lactam antibiotics in clinically significant types of microorganisms is extremely important, since β-lactams traditionally form the basis of the treatment of bacterial infections.
Olena Peretyatko, Yuliia Yagniuk, Nadiya Sklyar, Galina Bolshakova, Tetyana Holodna   +4 more
doaj   +1 more source

Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii

Antimicrobial Agents and Chemotherapy, 2020
QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor that demonstrates inhibition of key serine and metallo-beta-lactamases at a nanomolar concentration range in biochemical assays with purified enzymes.
O. Lomovskaya, Kirk J. Nelson, Debora Rubio-Aparicio, Ruslan Tsivkovski, Dongxu Sun, M. Dudley   +5 more
semanticscholar   +1 more source