Effect of β-lactamase inhibitors on in vitro activity of β-lactam antibiotics against Burkholderia cepacia complex species [PDF]
, 2016 Background: Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients. Intrinsic resistance to a wide range of antimicrobial agents, including a variety of beta-
Coenye, Tom, Everaert, Annelien
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A Primer on AmpC Beta-Lactamases: Necessary Knowledge for an Increasingly Multidrug-Resistant World.
Clinical Infectious Diseases, 2019 Understanding the nuances of AmpC β-lactamase mediated resistance can be challenging - even for the infectious diseases specialist. AmpC resistance can be classified into three categories: (a) inducible chromosomal resistance that emerges in the setting ...
P. Tamma +7 more
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Journal of Education, Health and Sport, 2019 New Delhi, an enzyme belonging to the Metallo-beta-lactamases and Carbapenemases group, is most commonly found in Klebsiella pneumoniae and Escherichia coli. It determines these bacteria resistance to the majority of known antibiotics.
Kamil Leis +13 more
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The reaction mechanism of metallo-beta-lactamases is tuned by the conformation of an active site mobile loop [PDF]
, 2018 Carbapenems are "last resort" β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria.
Alzari, Pedro M. +10 more
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Droplet-based digital antibiotic susceptibility screen reveals single-cell clonal heteroresistance in an isogenic bacterial population [PDF]
, 2020 Since antibiotic resistance is a major threat to global health, recent observations that the traditional test of minimum inhibitory concentration (MIC) is not informative enough to guide effective antibiotic treatment are alarming.
Debski, Pawel R. +9 more
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Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases [PDF]
Antimicrobial Agents and Chemotherapy, 1995 The effects of acidic conditions on activities of seven beta-lactamases--TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)--and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5.
S, Ohsuka +4 more
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Severe bloodstream infection due to KPC-producer e coli in a renal transplant recipient treated with the double-carbapenem regimen and analysis of in vitro synergy testing a case report [PDF]
, 2016 Transplant recipients are at high risk of infections caused by multidrug resistant microorganisms. Due to the limited thera- peutic options, innovative antimicrobial combinations against carbape- nem-resistant Enterobacteriaceae causing severe infections
CIPOLLA, ALESSIA +11 more
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The Growing Genetic and Functional Diversity of Extended Spectrum Beta-Lactamases
BioMed Research International, 2018 The β-lactams—a large class of diverse compounds—due to their excellent safety profile and broad antimicrobial spectrum are considered to be the most widely used therapeutic class of antibacterials prescribed in human and veterinary clinical practices ...
S. ur Rahman +5 more
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More extended-spectrum beta-lactamases [PDF]
Antimicrobial Agents and Chemotherapy, 1991 G. Jacoby, A. Medeiros
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Journal of Health Sciences, 2017 Introduction: Co-existence type of ESBL-producing isolates are serious problem in the public health world. Methods Antibiotic susceptibility was determined by disc diffusion and broth microdilution according to CLSI guidelines.
Amir Ibrahimagić +2 more
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