Results 71 to 80 of about 1,206,666 (303)

Plasmid Profiling and Occurrence of β-Lactamase Enzymes in Multidrug-Resistant Uropathogenic Escherichia coli in Kathmandu, Nepal

Infection and Drug Resistance, 2020
Upendra Thapa Shrestha,1,2,* Sabnum Shrestha,1,* Nabaraj Adhikari,1,2 Komal Raj Rijal,2 Basudha Shrestha,3 Bipin Adhikari,4 Megha Raj Banjara,2 Prakash Ghimire2 1Kantipur College of Medical Science, Tribhuvan University, Sitapaila, Kathmandu, Nepal ...
Thapa Shrestha U, Shrestha S, Adhikari N, Rijal KR, Shrestha B, Adhikari B, Banjara MR, Ghimire P   +7 more
doaj  

Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases.

PLoS Computational Biology, 2016
Beta-lactamases represent the main bacterial mechanism of resistance to beta-lactam antibiotics and are a significant challenge to modern medicine. We have developed an automated classification and analysis protocol that exploits structure- and sequence ...
David Lee, Sayoni Das, Natalie L Dawson, Dragana Dobrijevic, John Ward, Christine Orengo   +5 more
doaj   +1 more source

Dutch patients, retail chicken meat and poultry share the same ESBL genes, plasmids and strains [PDF]

Intestinal carriage of extended-spectrum beta-lactamase (ESBL) -producing bacteria in food-producing animals and contamination of retail meat may contribute to increased incidences of infections with ESBL-producing bacteria in humans.
Bonten, M.J.M., Cohen Stuart, J., Dierikx, C.M., Essen-Zandbergen, A., Van, Fluit, A.C., Leverstein-van Hall, M.A., Mevius, D.J., Munckhof, M.P., Van den, Platteel, T., Sande-Bruinsma, N., Van de, Scharinga, J., Voets, G.M.   +11 more
core   +2 more sources

Massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs

Microbiology Spectrum
Gram-negative bacilli-producing beta-lactamases are major causes of difficult-to-treat infections, especially the AmpC, extended-spectrum beta-lactamases (ESBL), and carbapenemase types. Their spread within and outside hospital settings demands effective
Gabriel Taddeucci-Rocha, Victoria de Oliveira Costa, Sarah Vitória Martins da Silva, Jéssica Britto Gonçalves, Natalia Chilinque Zambão da Silva, Marcia Maiolino Garnica, Renata Cristina Picão   +6 more
doaj   +1 more source

Identification of extended spectrum beta lactamases, AmpC and carbapenemase production among isolates of Escherichia coli in North Indian tertiary care centre

Avicenna Journal of Medicine, 2018
Introduction: Identification of Extended spectrum beta lactamases (ESBL), AmpC production and carbapenemase production among isolates of Escherichia coli, helps clinician to rationalize the choice of antibiotics.
Uma Chaudhary, Shipra Agarwal, Kausalya Raghuraman   +2 more
doaj   +1 more source

Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor

Nature Communications, 2020
Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al.
Dor Russ, Fabian Glaser, Einat Shaer Tamar, Idan Yelin, Michael Baym, Eric D. Kelsic, Claudia Zampaloni, Andreas Haldimann, Roy Kishony   +8 more
doaj   +1 more source

Evaluation of phenotypic tests for the detection of AmpC beta-lactamase in clinical isolates of Escherichia coli

Indian Journal of Pathology and Microbiology, 2013
Background: AmpC beta lactamases are cephalosporinases that confer resistance to a wide range of beta lactam drugs thereby causing serious therapeautic problem.
Deepika Handa, Anita Pandey, Ashish Kumar Asthana, Ashutosh Rawat, Seemant Handa, Bhaskar Thakuria   +5 more
doaj   +1 more source

Prevalence of extended-spectrum beta-lactamase-producing Klebsiella Pneumoniae isolates in nosocomial and community-acquired urinary tract infections [PDF]

, 2016
Background: Klebsiella pneumoniae is a family member of Enterobacteriaceae. Isolates of K. pneumoniae produce enzymes that cause decomposition of third generation cephalosporins.
Damavandi, M.S., Gholipour, A., Latifpour, M.   +2 more
core   +1 more source

Phenotypic characterization of beta-lactamases producing Gram-negative bacteria in a tertiary hospital, Nepal

Nepal Journal of Biotechnology, 2019
Infections caused by beta-lactamases producing Gram-negative bacteria are increasing, thus posing a challenge to the management of such infections.
Elina Maharjan, Pooja Shakya, Balkrishna Bhattachan, Bharat Prasad Baral, Dhiraj Shrestha   +4 more
doaj   +1 more source

Antimicrobial Resistance Patterns in Clinical Isolates of Enterobacteriaceae from a Tertiary Care Hospital, Kathmandu, Nepal

Nepalese Medical Journal, 2018
Introduction: Multidrug resistance among Enterobacteriaceae is in increasing trend these days. The objective of this study was to determine the antibiogram of clinical isolates of Enterobacteriaceae with special reference to multidrug resistance and ...
Ram Prasad Adhikari, Subha Shrestha, Junu Richhinbung Rai, Ritu Amatya   +3 more
doaj   +1 more source