Results 151 to 160 of about 39,817 (237)

Enhancing diabetic foot osteomyelitis diagnosis with metagenomics next‐generation sequencing, proof of concept

Diabetic Medicine, Volume 43, Issue 4, April 2026.
The use of mNGS with the MinION tool clearly provides a significant advantage compared to routine culture by identifying a higher diversity of pathogens in diabetic foot osteomyelitis. It also highlights the value of this method in clinical decision making, despite the technical challenges inherent in metagenomic sequencing.
Madjid Morsli, Chloé Magnan, Florian Salipante, Adeline Dubois, Sophie Schuldiner, Nicolas Cellier, Albert Sotto, Jean‐Philippe Lavigne, Catherine Dunyach‐Remy   +8 more
wiley   +1 more source

Direct oral provocation test with beta-lactams in Brazilian children and adolescents. [PDF]

J Pediatr (Rio J)
de Almeida NMG, Felix MMR, Ferreira MIPL, Kuschnir FC.   +3 more
europepmc   +1 more source

First Detection of Lactococcus formosensis subsp. formosensis in Rainbow Trout (Oncorhynchus mykiss) in Europe

Journal of Fish Diseases, Volume 49, Issue 4, April 2026.
ABSTRACT Lactococcus garvieae, Lactococcus petauri and Lactococcus formosensis are etiological agents of piscine lactococcosis, a disease reported in Italy since the early 1990s and linked to significant aquaculture losses. To the best of our knowledge, this study reports the first detection of L. formosensis subsp. formosensis in farmed rainbow trout (
Silvia Colussi, Giuseppe Esposito, Khalid Shahin, Pier Luigi Acutis, Lucio Fariano, Claudio Ghittino, Maria Goria, Fabio Bondavalli, Paolo Ajmone Marsan, Giorgia Bignami, Elena Bozzetta, Marino Prearo, Paolo Pastorino   +12 more
wiley   +1 more source

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Two Comprehensive Liquid Chromatography High-Resolution Mass Spectrometry (UPLC-MS/MS) Multi-Methods for Real-Time Therapeutic Drug Monitoring (TDM) of Five Novel Beta-Lactams and of Fosfomycin Administered by Continuous Infusion. [PDF]

Pharmaceutics
Trozzi I, Giorgi B, De Paola R, Gatti M, Pea F.   +4 more
europepmc   +1 more source

Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
An AlphaFold 2 model of a peptide derived from zinc finger translocation associated (ZFTA) protein in complex with the Kelch domain of KLHL20 (KLHL20Kelch). Sensorgrams from surface plasmon resonance biosensor experiments of the interaction between a ZFTA‐derived peptide with immobilised KLHL20Kelch shows that the interaction is complex and has a ...
Nadine E. M. Myers, Joanna Whittaker, Marie Elodie Hélène Cadot, Julia K. Varga, Marcel Diallo, Jakob Nilsson, Anders Bach, Anja Sandström, Ora Schueler‐Furman, U. Helena Danielson   +9 more
wiley   +1 more source

Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin With Concomitant Piperacillin-Tazobactam Versus Other Beta-Lactams: A Systematic Review and Meta-Analysis. [PDF]

J Pharm Technol
Li R, Li Y, Xu C, Shen Z, Xu X, Ding X, Li X, Lv Q, Pan K.   +8 more
europepmc   +1 more source

Development of a UHPLC-UV/Vis Method for Simultaneously Determining Six Beta-Lactam Antibiotics in Plasma: A Tool for the Clinical Implementation of Therapeutic Monitoring of Beta-Lactams. [PDF]

Antibiotics (Basel)
Varela-Rey I, Martínez-Guitián M, Hermelo-Vidal G, Bandín-Vilar E, Novo-Veleiro I, Varela-García PM, Zarra-Ferro I, González-Barcia M, Mondelo-García C, Fernández-Ferreiro A.   +9 more
europepmc   +1 more source

Chiral Potassium Brønsted Base‐Catalyzed Stereoselective Synthesis of 1,3‐Diols via a Tandem Allylic Isomerization/Asymmetric Aldol–Tishchenko Reaction

Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
Chiral potassium base catalysts featuring 1,1´‐bi‐2‐naphthol‐derived chiral crown ethers as ligands promote a tandem allylic isomerization/asymmetric aldol‐Tishchenko reaction of allylic alcohols and aldehydes. This method provides enantioenriched 1,3‐diols with excellent diastereoselectivity and high enantioselectivity, thereby expanding the synthetic
Hiroki Ishikawa, Masahiro Sai
wiley   +1 more source

Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection. [PDF]

Nat Commun
Cristinziano M, Shashkina E, Chen L, Xiao J, Miller MB, Doligalski C, Coakley R, Lobo LJ, Footer B, Bartelt L, Abad L, Russell DA, Garlena R, Lauer MJ, Viland M, Kaganovsky A, Mowry E, Jacobs-Sera D, van Duin D, Kreiswirth BN, Hatfull GF, Friedland A.   +21 more
europepmc   +1 more source