Results 191 to 200 of about 27,905 (224)

Human beta-secretase (BACE) and BACE inhibitors: progress report.

Current topics in medicinal chemistry, 2006
A key step in the processing of the integral membrane protein APP, or Amyloid Precursor Protein is through the proteolytic cleavage by the enzyme beta-Secretase (BACE). The proteolysis of APP by BACE, followed by subsequent C-terminal cleavage(s) by gamma-secretase, results in the formation of the amyloid beta (Abeta) peptide.
openaire   +1 more source

Structural basis of γ-secretase inhibition and modulation by small molecule drugs

Cell, 2021
Guanghui Yang, Rui Zhou, Xuefei Guo
exaly  

beta-Secretase

RCSB Protein Data Bank, 2009
openaire   +1 more source

PL‐04–01: Targeting beta‐secretase

Alzheimer's & Dementia, 2013
openaire   +1 more source

Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions

Cell, 2017
Maria Szaruga, Bogdan Munteanu, Natalie S Ryan   +2 more
exaly  

γ-Secretase: proteasome of the membrane?

Nature Reviews Molecular Cell Biology, 2004
Raphael Kopan, Ma Xenia G Ilagan
exaly  

Beta Secretase

2007
openaire   +1 more source

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Science, 1999
Robert Vassar, David B Teplow, Martin Citron   +2 more
exaly  

Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase

Bioorganic Chemistry, 2014
Archana S Gurjar, Vincenza Andrisano
exaly  

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity

NeuroToxicology, 2013
Il Jun Kang, Min-Ju Kim, Misook Kim
exaly